3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for victims of sexual abuse with severe post-traumatic stress disorder: an open label pilot study in Brazil

Objective: To conduct Brazil’s first clinical trial employing 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for post-traumatic stress disorder (PTSD), given its high prevalence resulting from epidemic violence. Methods: Of 60 volunteers, four matched the inclusion & exclusion...

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Principais autores: Jardim, Alvaro V., Jardim, Dora V., Chaves, Bruno Rasmussen, Steglich, Matheus, Ot’alora G., Marcela, Mithoefer, Michael C., Silveira, Dartiu X. da, Tófoli, Luís F., Ribeiro, Sidarta Tollendal Gomes, Matthews, Rebecca, Doblin, Rick, Schenberg, Eduardo E.
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Idioma:English
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Assuntos:
N-Methyl-3,4-methylenedioxyamphetamine
Stress disorders, post-traumatic
Psychotherapy
Sexual abuse
Psychedelics
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/29711
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spelling ri-123456789-297112020-07-26T07:52:56Z 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for victims of sexual abuse with severe post-traumatic stress disorder: an open label pilot study in Brazil Jardim, Alvaro V. Jardim, Dora V. Chaves, Bruno Rasmussen Steglich, Matheus Ot’alora G., Marcela Mithoefer, Michael C. Silveira, Dartiu X. da Tófoli, Luís F. Ribeiro, Sidarta Tollendal Gomes Matthews, Rebecca Doblin, Rick Schenberg, Eduardo E. N-Methyl-3,4-methylenedioxyamphetamine Stress disorders, post-traumatic Psychotherapy Sexual abuse Psychedelics Objective: To conduct Brazil’s first clinical trial employing 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for post-traumatic stress disorder (PTSD), given its high prevalence resulting from epidemic violence. Methods: Of 60 volunteers, four matched the inclusion & exclusion criteria. Three patients with PTSD secondary to sexual abuse (diagnosed by the Structured Clinical Interview for DSM-IV and the Clinician Administered PTSD Scale for DSMV-4 [CAPS 4]) completed enrollment and treatment, following a standardized Multidisciplinary Association for Psychedelic Studies protocol consisting of 15 weekly therapy sessions: three with orally administered MDMA with concurrent psychotherapy and music, spaced approximately 1 month apart. CAPS-4 scores two months after the final MDMA session were the primary outcome. Results: No serious adverse events occurred. The most frequent adverse events were somatic pains and anguish. CAPS-4 reductions were always greater than 25 points. The final scores were 61, 27, and 8, down from baseline scores of 90, 78, and 72, respectively. All reductions were greater than 30%, which is indicative of clinically significant improvement. Secondary outcomes included lower Beck Depressive Inventory scores and higher Post-Traumatic Growth Inventory and Global Assessment of Functioning scores. Conclusions: Considering the current limitations in safe and efficacious treatments for PTSD and recent studies abroad with larger patient samples, MDMA-assisted psychotherapy could become a viable treatment in Brazil. 2020-07-23T13:44:27Z 2020-07-23T13:44:27Z 2020-07-03 article JARDIM, Alvaro V. et al. 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for victims of sexual abuse with severe post-traumatic stress disorder: an open label pilot study in Brazil. Braz. J. Psychiatry, São Paulo, jul. 2020. https://doi.org/10.1590/1516-4446-2020-0980. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462020005020203&lng=en&nrm=iso. Acesso em: 23 jul. 2020. https://repositorio.ufrn.br/jspui/handle/123456789/29711 10.1590/1516-4446-2020-0980 en Attribution-NonCommercial 3.0 Brazil http://creativecommons.org/licenses/by-nc/3.0/br/ application/pdf
institution Repositório Institucional
collection RI - UFRN
language English
topic N-Methyl-3,4-methylenedioxyamphetamine
Stress disorders, post-traumatic
Psychotherapy
Sexual abuse
Psychedelics
spellingShingle N-Methyl-3,4-methylenedioxyamphetamine
Stress disorders, post-traumatic
Psychotherapy
Sexual abuse
Psychedelics
Jardim, Alvaro V.
Jardim, Dora V.
Chaves, Bruno Rasmussen
Steglich, Matheus
Ot’alora G., Marcela
Mithoefer, Michael C.
Silveira, Dartiu X. da
Tófoli, Luís F.
Ribeiro, Sidarta Tollendal Gomes
Matthews, Rebecca
Doblin, Rick
Schenberg, Eduardo E.
3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for victims of sexual abuse with severe post-traumatic stress disorder: an open label pilot study in Brazil
description Objective: To conduct Brazil’s first clinical trial employing 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for post-traumatic stress disorder (PTSD), given its high prevalence resulting from epidemic violence. Methods: Of 60 volunteers, four matched the inclusion & exclusion criteria. Three patients with PTSD secondary to sexual abuse (diagnosed by the Structured Clinical Interview for DSM-IV and the Clinician Administered PTSD Scale for DSMV-4 [CAPS 4]) completed enrollment and treatment, following a standardized Multidisciplinary Association for Psychedelic Studies protocol consisting of 15 weekly therapy sessions: three with orally administered MDMA with concurrent psychotherapy and music, spaced approximately 1 month apart. CAPS-4 scores two months after the final MDMA session were the primary outcome. Results: No serious adverse events occurred. The most frequent adverse events were somatic pains and anguish. CAPS-4 reductions were always greater than 25 points. The final scores were 61, 27, and 8, down from baseline scores of 90, 78, and 72, respectively. All reductions were greater than 30%, which is indicative of clinically significant improvement. Secondary outcomes included lower Beck Depressive Inventory scores and higher Post-Traumatic Growth Inventory and Global Assessment of Functioning scores. Conclusions: Considering the current limitations in safe and efficacious treatments for PTSD and recent studies abroad with larger patient samples, MDMA-assisted psychotherapy could become a viable treatment in Brazil.
format article
author Jardim, Alvaro V.
Jardim, Dora V.
Chaves, Bruno Rasmussen
Steglich, Matheus
Ot’alora G., Marcela
Mithoefer, Michael C.
Silveira, Dartiu X. da
Tófoli, Luís F.
Ribeiro, Sidarta Tollendal Gomes
Matthews, Rebecca
Doblin, Rick
Schenberg, Eduardo E.
author_facet Jardim, Alvaro V.
Jardim, Dora V.
Chaves, Bruno Rasmussen
Steglich, Matheus
Ot’alora G., Marcela
Mithoefer, Michael C.
Silveira, Dartiu X. da
Tófoli, Luís F.
Ribeiro, Sidarta Tollendal Gomes
Matthews, Rebecca
Doblin, Rick
Schenberg, Eduardo E.
author_sort Jardim, Alvaro V.
title 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for victims of sexual abuse with severe post-traumatic stress disorder: an open label pilot study in Brazil
title_short 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for victims of sexual abuse with severe post-traumatic stress disorder: an open label pilot study in Brazil
title_full 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for victims of sexual abuse with severe post-traumatic stress disorder: an open label pilot study in Brazil
title_fullStr 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for victims of sexual abuse with severe post-traumatic stress disorder: an open label pilot study in Brazil
title_full_unstemmed 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for victims of sexual abuse with severe post-traumatic stress disorder: an open label pilot study in Brazil
title_sort 3,4-methylenedioxymethamphetamine (mdma)-assisted psychotherapy for victims of sexual abuse with severe post-traumatic stress disorder: an open label pilot study in brazil
publishDate 2020
url https://repositorio.ufrn.br/jspui/handle/123456789/29711
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