Análise da imunoexpressão de IL-17 e IL-23 em doenças tireoidianas
The thyroid is an endocrine gland that can be affected by several lesions, including reactive, autoimmune and neoplastic diseases. Evidence shows that the immune response, from the release of inflammatory cytokines by immune and non-immune cells, plays an important role in the development of seve...
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| Formato: | Dissertação |
| Idioma: | pt_BR |
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Universidade Federal do Rio Grande do Norte
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| Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/29621 |
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| Resumo: | The thyroid is an endocrine gland that can be affected by several lesions, including reactive,
autoimmune and neoplastic diseases. Evidence shows that the immune response, from the release
of inflammatory cytokines by immune and non-immune cells, plays an important role in the
development of several diseases. Among these cytokines, IL-17 and IL-23 stand out, which have
been associated with the Th17 response and pathogenesis of several thyroid diseases. Hence, this
research aimed to evaluate the immunoexpression of IL-17 and IL-23 proteins in papillary thyroid
carcinomas (PTCs), follicular adenomas (FAs), colloid goiters (CGs) and Hashimoto's thyroiditis
(HTs) (isolated and associated with PTCs or GCs), in order to better understand the role of these
cytokines in these entities. The sample consisted of 30 cases of PTCs, 10 FAs, 15 CGs and 15
HTs. The analysis of protein immunoexpression in follicular/tumor cells was semiquantitatively
performed in all lesions, which were classified into three scores: 1 (≤ 33%), 2 (> 33% - 66%) and
3 (> 66%). For the evaluation of immunopositive lymphocytes, five fields with the greater number
of positive lymphocytes were selected, where the count was performed. The data were submitted
to statistical analysis using the Kruskal-Wallis (KW), Mann-Whitney (U) and Spearman (r) tests,
with the significance level set at 5% (p < 0,05). In the analysis of IL-17 between lesions, a higher
immunoexpression was verified in the HT lymphocytes compared to FAs and CGs (p=0.041 and
p=0.013). In the evaluation of IL-23, a higher immunostaining of follicular/tumor cells in HTs was
detected in relation to PTCs (p=0.002), as well as, a greater expression of this cytokine was
observed in the lymphocytes of HTs compared to PTCs, FAs and CGs (p=0.001; p=0.023 and
p=0.003). In addition, statistically significant correlations between the immunoexpression of IL17 and IL-23 were observed in both follicular/tumor cells and lymphocytes (r=0.539; p=0.038 and
r=0.522; p=0.046). It is therefore suggested that IL-17 and IL-23 influence the pathogenesis of
these thyroid lesions and that in some of them, they represent the Th17 response. |
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