Development of a magnetic system for the treatment of Helicobacter pylori infections
We report a study to develop a magnetic system for local delivery of amoxicillin. Magnetite microparticles produced by coprecipitation were coated with a solution of amoxicillin and Eudragit®S100 by spray drying. Scanning electron microscopy, optical microscopy, X-ray powder diffraction and vibratin...
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ri-123456789-293122020-06-21T07:45:32Z Development of a magnetic system for the treatment of Helicobacter pylori infections Araújo, José Humberto de Silva, Érica Lira Carvalho, Juliana Fernandes Pontes, Thales Renan Ferreira Oliveira, Elquio Eleamen Francelino, Bárbara L. Medeiros, Aldo da Cunha Carriço, Arthur da Silva Egito, Eryvaldo Sócrates Tabosa do Magnetic vectorization Helicobacter pylori Magnetite microparticle Pray drying coating Superparamagnetic particle We report a study to develop a magnetic system for local delivery of amoxicillin. Magnetite microparticles produced by coprecipitation were coated with a solution of amoxicillin and Eudragit®S100 by spray drying. Scanning electron microscopy, optical microscopy, X-ray powder diffraction and vibrating sample magnetometry revealed that the particles were superparamagnetic, with an average diameter of 17.2 μm, and an initial susceptibility controllable by the magnetite content in the suspension feeding the sprayer. Our results suggest a possible way to treat Helicobacter pylori infections, using an oral drug delivery system, and open prospects to coat magnetic microparticles by spray drying for biomedical applications 2020-06-19T18:29:19Z 2020-06-19T18:29:19Z 2010-03-05 article SILVA, Érica L.; CARVALHO, Juliana F.; PONTES, Thales R.F.; OLIVEIRA, Elquio E.; FRANCELINO, Bárbara L.; MEDEIROS, Aldo C.; EGITO, E. Sócrates T.; ARAÚJO, José H. ; Carriço, Artur S.. Development of a magnetic system for the treatment of Helicobacter pylori infections. Journal of Magnetism and Magnetic Materials, v. 321, p. 1566-1570, 2009. Disponível em: https://www.sciencedirect.com/science/article/pii/S0304885309001553?via%3Dihub#!. Acesso em: 18 jun 2020. https://doi.org/10.1016/j.jmmm.2009.02.087. 0304-8853 https://repositorio.ufrn.br/jspui/handle/123456789/29312 10.1016/j.jmmm.2009.02.087 en Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ application/pdf Elsevier |
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English |
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Magnetic vectorization Helicobacter pylori Magnetite microparticle Pray drying coating Superparamagnetic particle |
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Magnetic vectorization Helicobacter pylori Magnetite microparticle Pray drying coating Superparamagnetic particle Araújo, José Humberto de Silva, Érica Lira Carvalho, Juliana Fernandes Pontes, Thales Renan Ferreira Oliveira, Elquio Eleamen Francelino, Bárbara L. Medeiros, Aldo da Cunha Carriço, Arthur da Silva Egito, Eryvaldo Sócrates Tabosa do Development of a magnetic system for the treatment of Helicobacter pylori infections |
| description |
We report a study to develop a magnetic system for local delivery of amoxicillin. Magnetite microparticles produced by coprecipitation were coated with a solution of amoxicillin and Eudragit®S100 by spray drying. Scanning electron microscopy, optical microscopy, X-ray powder diffraction and vibrating sample magnetometry revealed that the particles were superparamagnetic, with an average diameter of 17.2 μm, and an initial susceptibility controllable by the magnetite content in the suspension feeding the sprayer. Our results suggest a possible way to treat Helicobacter pylori infections, using an oral drug delivery system, and open prospects to coat magnetic microparticles by spray drying for biomedical applications |
| format |
article |
| author |
Araújo, José Humberto de Silva, Érica Lira Carvalho, Juliana Fernandes Pontes, Thales Renan Ferreira Oliveira, Elquio Eleamen Francelino, Bárbara L. Medeiros, Aldo da Cunha Carriço, Arthur da Silva Egito, Eryvaldo Sócrates Tabosa do |
| author_facet |
Araújo, José Humberto de Silva, Érica Lira Carvalho, Juliana Fernandes Pontes, Thales Renan Ferreira Oliveira, Elquio Eleamen Francelino, Bárbara L. Medeiros, Aldo da Cunha Carriço, Arthur da Silva Egito, Eryvaldo Sócrates Tabosa do |
| author_sort |
Araújo, José Humberto de |
| title |
Development of a magnetic system for the treatment of Helicobacter pylori infections |
| title_short |
Development of a magnetic system for the treatment of Helicobacter pylori infections |
| title_full |
Development of a magnetic system for the treatment of Helicobacter pylori infections |
| title_fullStr |
Development of a magnetic system for the treatment of Helicobacter pylori infections |
| title_full_unstemmed |
Development of a magnetic system for the treatment of Helicobacter pylori infections |
| title_sort |
development of a magnetic system for the treatment of helicobacter pylori infections |
| publisher |
Elsevier |
| publishDate |
2020 |
| url |
https://repositorio.ufrn.br/jspui/handle/123456789/29312 |
| work_keys_str_mv |
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| _version_ |
1773963308504711168 |