Changes in cortisol but not in brain-derived neurotrophic factor modulate the association between sleep disturbances and major depression

Sleep disturbance is a symptom consistently found in major depression and is associated with a longer course of illness, reduced response to treatment, increased risk of relapse and recurrence. Chronic insomnia has been associated with changes in cortisol and serum brain-derived neurotrophic factor...

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Principais autores:	Santiago, Giuliana Travassos Pires, Galvão, Ana Cecília de Menezes, Almeida, Raíssa Nóbrega de, Mota-Rolim, Sergio Arthuro, Palhano-Fontes, Fernanda, Maia-de-Oliveira, João Paulo, Araújo, Dráulio Barros de, Lobão-Soares, Bruno, Galvão-Coelho, Nicole Leite
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Idioma:	English
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Assuntos:	Pittsburgh sleep quality index brain-derived neurotrophic factor salivary cortisol awakening response sleep disturbance treatment-resistant depression
Endereço do item:	https://repositorio.ufrn.br/jspui/handle/123456789/28961
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id	ri-123456789-28961
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spelling	ri-123456789-289612020-05-17T08:00:30Z Changes in cortisol but not in brain-derived neurotrophic factor modulate the association between sleep disturbances and major depression Santiago, Giuliana Travassos Pires Galvão, Ana Cecília de Menezes Almeida, Raíssa Nóbrega de Mota-Rolim, Sergio Arthuro Palhano-Fontes, Fernanda Maia-de-Oliveira, João Paulo Araújo, Dráulio Barros de Lobão-Soares, Bruno Galvão-Coelho, Nicole Leite Pittsburgh sleep quality index brain-derived neurotrophic factor salivary cortisol awakening response sleep disturbance treatment-resistant depression Sleep disturbance is a symptom consistently found in major depression and is associated with a longer course of illness, reduced response to treatment, increased risk of relapse and recurrence. Chronic insomnia has been associated with changes in cortisol and serum brain-derived neurotrophic factor (BDNF) levels, which in turn are also changed in major depression. Here, we evaluated the relationship between sleep quality, salivary cortisol awakening response (CAR), and serum BDNF levels in patients with sleep disturbance and treatment-resistant major depression (n = 18), and in a control group of healthy subjects with good (n = 21) and poor (n = 18) sleep quality. We observed that the patients had the lowest CAR and sleep duration of all three groups and a higher latency to sleep than the healthy volunteers with a good sleep profile. Besides, low CAR was correlated with more severe depressive symptoms and worse sleep quality. There was no difference in serum BDNF levels between groups with distinct sleep quality. Taken together, our results showed a relationship between changes in CAR and in sleep quality in patients with treatment-resistant depression, which were correlated with the severity of disease, suggesting that cortisol could be a physiological link between sleep disturbance and major depression. 2020-05-12T18:07:12Z 2020-05-12T18:07:12Z 2020-04-28 article SANTIAGO, G. T. P. et al. Changes in cortisol but not in brain-derived neurotrophic factor modulate the association between sleep disturbances and major depression. Front. Behav. Neurosci., [S. l.], v. 14, p.44, abr. 2020. https://repositorio.ufrn.br/jspui/handle/123456789/28961 10.3389/fnbeh.2020.00044 en application/pdf
institution	Repositório Institucional
collection	RI - UFRN
language	English
topic	Pittsburgh sleep quality index brain-derived neurotrophic factor salivary cortisol awakening response sleep disturbance treatment-resistant depression
spellingShingle	Pittsburgh sleep quality index brain-derived neurotrophic factor salivary cortisol awakening response sleep disturbance treatment-resistant depression Santiago, Giuliana Travassos Pires Galvão, Ana Cecília de Menezes Almeida, Raíssa Nóbrega de Mota-Rolim, Sergio Arthuro Palhano-Fontes, Fernanda Maia-de-Oliveira, João Paulo Araújo, Dráulio Barros de Lobão-Soares, Bruno Galvão-Coelho, Nicole Leite Changes in cortisol but not in brain-derived neurotrophic factor modulate the association between sleep disturbances and major depression
description	Sleep disturbance is a symptom consistently found in major depression and is associated with a longer course of illness, reduced response to treatment, increased risk of relapse and recurrence. Chronic insomnia has been associated with changes in cortisol and serum brain-derived neurotrophic factor (BDNF) levels, which in turn are also changed in major depression. Here, we evaluated the relationship between sleep quality, salivary cortisol awakening response (CAR), and serum BDNF levels in patients with sleep disturbance and treatment-resistant major depression (n = 18), and in a control group of healthy subjects with good (n = 21) and poor (n = 18) sleep quality. We observed that the patients had the lowest CAR and sleep duration of all three groups and a higher latency to sleep than the healthy volunteers with a good sleep profile. Besides, low CAR was correlated with more severe depressive symptoms and worse sleep quality. There was no difference in serum BDNF levels between groups with distinct sleep quality. Taken together, our results showed a relationship between changes in CAR and in sleep quality in patients with treatment-resistant depression, which were correlated with the severity of disease, suggesting that cortisol could be a physiological link between sleep disturbance and major depression.
format	article
author	Santiago, Giuliana Travassos Pires Galvão, Ana Cecília de Menezes Almeida, Raíssa Nóbrega de Mota-Rolim, Sergio Arthuro Palhano-Fontes, Fernanda Maia-de-Oliveira, João Paulo Araújo, Dráulio Barros de Lobão-Soares, Bruno Galvão-Coelho, Nicole Leite
author_facet	Santiago, Giuliana Travassos Pires Galvão, Ana Cecília de Menezes Almeida, Raíssa Nóbrega de Mota-Rolim, Sergio Arthuro Palhano-Fontes, Fernanda Maia-de-Oliveira, João Paulo Araújo, Dráulio Barros de Lobão-Soares, Bruno Galvão-Coelho, Nicole Leite
author_sort	Santiago, Giuliana Travassos Pires
title	Changes in cortisol but not in brain-derived neurotrophic factor modulate the association between sleep disturbances and major depression
title_short	Changes in cortisol but not in brain-derived neurotrophic factor modulate the association between sleep disturbances and major depression
title_full	Changes in cortisol but not in brain-derived neurotrophic factor modulate the association between sleep disturbances and major depression
title_fullStr	Changes in cortisol but not in brain-derived neurotrophic factor modulate the association between sleep disturbances and major depression
title_full_unstemmed	Changes in cortisol but not in brain-derived neurotrophic factor modulate the association between sleep disturbances and major depression
title_sort	changes in cortisol but not in brain-derived neurotrophic factor modulate the association between sleep disturbances and major depression
publishDate	2020
url	https://repositorio.ufrn.br/jspui/handle/123456789/28961
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Changes in cortisol but not in brain-derived neurotrophic factor modulate the association between sleep disturbances and major depression

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