Alterações dentárias em crianças com microcefalia associada à Síndrome Congênita do Zika Vírus e outras infecções congênitas
The consequences of microcephaly associated with Congenital Zika Virus Syndrome (CZS) and other congenital infections on the dental development of the affected child are not well known. The objectives of this study were to evaluate the frequency of dental alterations in children with microcephaly...
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| Formato: | doctoralThesis |
| Idioma: | pt_BR |
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| Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/28639 |
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| Resumo: | The consequences of microcephaly associated with Congenital Zika Virus Syndrome (CZS)
and other congenital infections on the dental development of the affected child are not well
known. The objectives of this study were to evaluate the frequency of dental alterations in
children with microcephaly, to analyze if there is an association of dental alterations with
CZS, and to verify if microcephaly is a risk factor for dental alterations. For this, two crosssectional observational studies and one case-control study were performed. A single
calibrated examiner (Kappa > 0,8) evaluated the presence of dental alterations of number,
shape and size, alterations in the chronology and sequence of tooth eruption, and alterations in
the tooth enamel development in children with CZS and other congenital infections, as well as
in normoreactive children. Information related to mothers’ pregnancies and child births were
collected and a socioeconomic questionnaire was applied. Data were descriptively evaluated
and chi-square test and Fisher’s exact test were used as association tests considering a
significance level of 5% (studies 2 and 3). The first study sample consisted of 49 children
between 7 and 35 months of age with CZS-associated microcephaly. The most prevalent
alterations were related to the eruption chronology (93.9%), changes in the development of
the enamel (76.1%) and the dental eruption sequence (71.7%). Next, 62 children aged 7 to 35
months with CZS-associated microcephaly and other congenital infections comprised the
sample in the second study. There was no statistically significant association between CZS
and the presence of changes in chronology (p = 1.00), sequence of tooth eruption (p = 0.16)
and tooth enamel development (p = 1.00). In the case-control study, 81 normoreactive
children and children with microcephaly between 30 and 35 months of age were part of the
sample, which were then paired by gender and age at a 1:1 ratio after identifying the
frequencies of each of the dental alterations, and then allocated to the case (presence of dental
changes) or control (absence of dental changes) groups. The presence of microcephaly was
statistically associated with delayed tooth eruption (p<0.001), the presence of changes in tooth
eruption sequence (p<0.001) and dental enamel defects (p<0.001). It was concluded that
children with CZS-associated microcephaly had delayed dental eruption, alterations in the
eruptive sequence and hypomineralization of primary tooth enamel; however, a Zika virus
infection was not associated with these dental changes. A microcephaly, regardless of its
etiology, is a risk factor for changes related to the tooth eruption process and the development
of primary tooth enamel. It is concluded that microcephaly associated with CZS and other congenital infections is a risk factor for delayed tooth eruption, alterations in the eruptive sequence and defects in dental
enamel development occurring. |
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