Análise imunohistoquímica do Gata-3 e Il-4 em carcinomas epidermóides de lábio inferior e língua oral
Squamous cell carcinoma (SCC) is the most common malignant neoplasm in the oral cavity, with the lower lip and oral tongue being the most frequent sites. Like all malignancies, SCC has etiology is multifactorial, with strong association with smoking, alcoholism and chronic exposure to solar radia...
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| Formato: | Dissertação |
| Idioma: | pt_BR |
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Brasil
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| Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/28281 |
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| Resumo: | Squamous cell carcinoma (SCC) is the most common malignant neoplasm in the
oral cavity, with the lower lip and oral tongue being the most frequent sites. Like
all malignancies, SCC has etiology is multifactorial, with strong association with
smoking, alcoholism and chronic exposure to solar radiation. At present many
studies have turned attention to the role of the inflammatory response in the
development and tumor growth, mainly with respect to the cellular immune
response. The aim of this study is to analyze the expression of GATA-3 and IL-4
in squamous cell carcinoma of the lower lip (SCCLL) and oral tongue (SCCOT).
The selected cases were classified according to the WHO histological grading of
malignancy and the immunohistochemical analysis of GATA-3 and IL-4 in 57
cases of SCCLL and SCCOT. The results showed statistical significance of
GATA-3 in the stromal (p < 0.05) of these lesions and IL-4 in the parenchyma (p
< 0.01), in the stroma (p < 0.01) and in the parenchyma and stroma together (p
< 0.01). It also showed a positive correlation between the expression of GATA-3
in the parenchyma and IL-4 in the parenchyma (r = 0.438, p = 0.001), between
GATA-3 in the parenchyma and IL-4 in the stroma (r = 0.378; p = 0.004), and
between GATA-3 in the parenchyma and IL-4 in the parenchyma and stroma (r =
0.348; p = 0.008). Therefore, in all cases, the presence of the Th2 response was
observed, implying the opening of new horizons in this area for new studies that
may contribute to the understanding of this response in the growth and
development of these lesions. |
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