Análise térmica de hormônios bioidêntico: uma abordagem quantitativa
Bioidentical hormones are compounds that have exactly the same chemical and molecular structure as endogenous human hormones. Among which may be mentioned those stakeholders female characters usually are prescribed House on menopause and are environmentally by the pharmaceutical industry, requir...
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| Formato: | Dissertação |
| Idioma: | pt_BR |
| Publicado em: |
Brasil
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| Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/28144 |
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| Resumo: | Bioidentical hormones are compounds that have exactly the same chemical and
molecular structure as endogenous human hormones. Among which may be
mentioned those stakeholders female characters usually are prescribed House
on menopause and are environmentally by the pharmaceutical industry,
requiring the development of methods of quality control of medicines. In this
work, we developed and validated a method of analysis based on the technique
of reducing differential analysis (DTA). DTA analysis was performed on
Shimadzu thermobalance, model DTG-60 (simultaneous TG/DTA), under
dynamic atmosphere of N2 at 50 mL min-1
, using aluminum pan with about
approximately 5 mg of samples and heating rate of 10 ºC min-1
in the from 25 -
300 ºC. The validation of analytical method for DTA was carried out with the
determination of selectivity, analytical curve and linearity, precision, limit of
detection an limit of quantification, accuracy and robustness. The method
exhibits good linearity from 1-5 mg with determination coefficient 0,995, precise
(R.S.D < 2,0%), accuracy (recovery of 99,99%), selectivity and robustness. The
LOD and LQ values were determined to be 0,07 and 0,22 mg, respectively.
Using the DTA in the routine of pharmaceutical analysis will allow you to
eliminate the use of organic solvents and reduce the time of analysis, when
compared to the other methods. |
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