Status de zinco e cobre e associações com parâmetros biodemográficos, clínicos, bioquímicos e nutricionais em indivíduos com insuficiência cardíaca
Heart failure (HF) is a complex syndrome with two predominant etiologies, ischemic HF and non-ischemic HF. There are gaps on the impact of the etiology and other factors associated with HF on zinc and copper status. The aim was to investigate the zinc and copper status in individuals with ischemi...
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| Formato: | Dissertação |
| Idioma: | pt_BR |
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Brasil
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| Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/28050 |
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| Resumo: | Heart failure (HF) is a complex syndrome with two predominant etiologies,
ischemic HF and non-ischemic HF. There are gaps on the impact of the etiology and
other factors associated with HF on zinc and copper status. The aim was to investigate
the zinc and copper status in individuals with ischemic and non-ischemic HF, and the
associations with biodemographic, clinical, biochemical and nutritional parameters.
This is a cross-sectional study that included 80 patients with HF who were treated in
an outpatient setting, grouped with ischemic (n=36) and non-ischemic HF (n=44). Zinc
biomarkers (plasma, urine and dietary zinc), copper biomarkers (plasma and dietary
copper, and ceruloplasmin) and copper/zinc ratio were investigated. Student's t-tests,
Mann-Whitney, Chi-square or Fisher's exact test were used when appropriate. Multiple
linear regression using the stepwise method was used to evaluate associations. We
observed lower zinc intake and higher copper intake in the group with ischemic HF
(both p=0.02). No differences were detected in plasma zinc and copper, copper/zinc
ratio, ceruloplasmin and urine zinc between the groups (all p≥0.05). The median values
of these biomarkers were within reference range in both groups. Inverse associations
were observed between plasma zinc and age (β=-0.001, p=0.005) and use of diuretic
(β=-0.047, p=0.013). Transferrin saturation (β=-0.002, p=0.014), plasma copper
(β=0.001, p<0.001), albumin (β=0.090, p<0.001) and ischemic etiology (β=0.038;
p=0.012) were directly associated with plasma zinc. It was identified a direct
association between ceruloplasmin (β=0.011, p<0.001), GGT (β=0.001, p <0.001),
albumin (β=0.077, p=0.001), hs-CRP (β=0.001, p=0.024), dietary calcium (β=0.00015,
p=0.015) and plasma copper. On the other hand, the independent variables previous
alcoholism (β=-0.070, p<0.001) and dietary fiber (β=-0.016, p=0.008) were inversely
associated with plasma copper. The results suggest that there are no significant
changes in zinc and copper status in ambulatory individuals with HF, regardless of the
etiology of HF. It is important to monitore the predictive variables of plasma zinc and
copper related to the context of HF, especially those associated with oxidative stress
and inflammation. |
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