The impact of ayahuasca on suicidality: results from a randomized controlled trial

Suicide is a major public health problem. Given increasing suicide rates and limitations surrounding current interventions, there is an urgent need for innovative interventions for suicidality. Although ayahuasca has been shown to target mental health concerns associated with suicidality (i.e., depr...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Principais autores: Zeifman, Richard J., Palhano-Fontes, Fernanda, Hallak, Jaime, Arcoverde, Emerson, Maia-Oliveira, João Paulo, Araújo, Dráulio Barros de
Formato: article
Idioma:English
Publicado em:
Assuntos:
Suicidality
ayahuasca
psychedelics
randomized controlled trial
novel intervention
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/27933
https://doi.org/10.3389/fphar.2019.01325
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
id ri-123456789-27933
record_format dspace
spelling ri-123456789-279332021-07-08T18:31:00Z The impact of ayahuasca on suicidality: results from a randomized controlled trial Zeifman, Richard J. Palhano-Fontes, Fernanda Hallak, Jaime Arcoverde, Emerson Maia-Oliveira, João Paulo Araújo, Dráulio Barros de Suicidality ayahuasca psychedelics randomized controlled trial novel intervention Suicide is a major public health problem. Given increasing suicide rates and limitations surrounding current interventions, there is an urgent need for innovative interventions for suicidality. Although ayahuasca has been shown to target mental health concerns associated with suicidality (i.e., depression and hopelessness), research has not yet explored the impact of ayahuasca on suicidality. Therefore, we conducted secondary analyses of a randomized placebo-controlled trial in which individuals with treatment-resistant depression were administered one dose of ayahuasca (n = 14) or placebo (n = 15). Suicidality was assessed by a trained psychiatrist at baseline, as well as 1 day, 2 days, and 7 days after the intervention. A fixed-effects linear mixed model, as well as between and within-groups Cohen's d effect sizes were used to examine changes in suicidality. Controlling for baseline suicidality, we found a significant effect for time (p < .05). The effect of the intervention (i.e., ayahuasca vs. placebo) trended toward significance (p = .088). At all time points, we found medium between-group effect sizes (i.e., ayahuasca vs. placebo; day 1 Cohen’s d = 0.58; day 2 d = 0.56; day 7 d = 0.67), as well as large within-group (ayahuasca; day 1 Cohen's d = 1.33; day 2 d = 1.42; day 7 d = 1.19) effect sizes, for decreases in suicidality. Conclusions: This research is the first to explore the impact of ayahuasca on suicidality. The findings suggest that ayahuasca may show potential as an intervention for suicidality. We highlight important limitations of the study, potential mechanisms, and future directions for research on ayahuasca as an intervention for suicidality. 2019-11-19T14:22:05Z 2019-11-19T14:22:05Z 2019-11-19 article ZEIFMAN, R.; PALHANO-FONTES, F.; HALLAK, J.; NUNES, E. A.; MAIA-DE-OLIVEIRA, J. P.; ARAUJO, D. B. The impact of ayahuasca on suicidality: results from a randomized controlled trial. Front. Pharmacol., [s. l.], v. 10, p. 1325, nov. 2019. Doi: 10.3389/fphar.2019.01325. https://repositorio.ufrn.br/jspui/handle/123456789/27933 https://doi.org/10.3389/fphar.2019.01325 en application/pdf
institution Repositório Institucional
collection RI - UFRN
language English
topic Suicidality
ayahuasca
psychedelics
randomized controlled trial
novel intervention
spellingShingle Suicidality
ayahuasca
psychedelics
randomized controlled trial
novel intervention
Zeifman, Richard J.
Palhano-Fontes, Fernanda
Hallak, Jaime
Arcoverde, Emerson
Maia-Oliveira, João Paulo
Araújo, Dráulio Barros de
The impact of ayahuasca on suicidality: results from a randomized controlled trial
description Suicide is a major public health problem. Given increasing suicide rates and limitations surrounding current interventions, there is an urgent need for innovative interventions for suicidality. Although ayahuasca has been shown to target mental health concerns associated with suicidality (i.e., depression and hopelessness), research has not yet explored the impact of ayahuasca on suicidality. Therefore, we conducted secondary analyses of a randomized placebo-controlled trial in which individuals with treatment-resistant depression were administered one dose of ayahuasca (n = 14) or placebo (n = 15). Suicidality was assessed by a trained psychiatrist at baseline, as well as 1 day, 2 days, and 7 days after the intervention. A fixed-effects linear mixed model, as well as between and within-groups Cohen's d effect sizes were used to examine changes in suicidality. Controlling for baseline suicidality, we found a significant effect for time (p < .05). The effect of the intervention (i.e., ayahuasca vs. placebo) trended toward significance (p = .088). At all time points, we found medium between-group effect sizes (i.e., ayahuasca vs. placebo; day 1 Cohen’s d = 0.58; day 2 d = 0.56; day 7 d = 0.67), as well as large within-group (ayahuasca; day 1 Cohen's d = 1.33; day 2 d = 1.42; day 7 d = 1.19) effect sizes, for decreases in suicidality. Conclusions: This research is the first to explore the impact of ayahuasca on suicidality. The findings suggest that ayahuasca may show potential as an intervention for suicidality. We highlight important limitations of the study, potential mechanisms, and future directions for research on ayahuasca as an intervention for suicidality.
format article
author Zeifman, Richard J.
Palhano-Fontes, Fernanda
Hallak, Jaime
Arcoverde, Emerson
Maia-Oliveira, João Paulo
Araújo, Dráulio Barros de
author_facet Zeifman, Richard J.
Palhano-Fontes, Fernanda
Hallak, Jaime
Arcoverde, Emerson
Maia-Oliveira, João Paulo
Araújo, Dráulio Barros de
author_sort Zeifman, Richard J.
title The impact of ayahuasca on suicidality: results from a randomized controlled trial
title_short The impact of ayahuasca on suicidality: results from a randomized controlled trial
title_full The impact of ayahuasca on suicidality: results from a randomized controlled trial
title_fullStr The impact of ayahuasca on suicidality: results from a randomized controlled trial
title_full_unstemmed The impact of ayahuasca on suicidality: results from a randomized controlled trial
title_sort impact of ayahuasca on suicidality: results from a randomized controlled trial
publishDate 2019
url https://repositorio.ufrn.br/jspui/handle/123456789/27933
https://doi.org/10.3389/fphar.2019.01325
work_keys_str_mv AT zeifmanrichardj theimpactofayahuascaonsuicidalityresultsfromarandomizedcontrolledtrial
AT palhanofontesfernanda theimpactofayahuascaonsuicidalityresultsfromarandomizedcontrolledtrial
AT hallakjaime theimpactofayahuascaonsuicidalityresultsfromarandomizedcontrolledtrial
AT arcoverdeemerson theimpactofayahuascaonsuicidalityresultsfromarandomizedcontrolledtrial
AT maiaoliveirajoaopaulo theimpactofayahuascaonsuicidalityresultsfromarandomizedcontrolledtrial
AT araujodrauliobarrosde theimpactofayahuascaonsuicidalityresultsfromarandomizedcontrolledtrial
AT zeifmanrichardj impactofayahuascaonsuicidalityresultsfromarandomizedcontrolledtrial
AT palhanofontesfernanda impactofayahuascaonsuicidalityresultsfromarandomizedcontrolledtrial
AT hallakjaime impactofayahuascaonsuicidalityresultsfromarandomizedcontrolledtrial
AT arcoverdeemerson impactofayahuascaonsuicidalityresultsfromarandomizedcontrolledtrial
AT maiaoliveirajoaopaulo impactofayahuascaonsuicidalityresultsfromarandomizedcontrolledtrial
AT araujodrauliobarrosde impactofayahuascaonsuicidalityresultsfromarandomizedcontrolledtrial
_version_ 1773965305173770240

Registros relacionados