Estimulação transcraniana por corrente contínua no transtorno de ansiedade generalizada: um estudo randomizado duplo cego
Introduction: Anxiety is a disorder that has been affecting a substantial number of individuals, presenting a prevalence of 9.3% of people affected in Brazil, being the country with the highest prevalence of this pathology among the countries of the Americas. Among the anxiety disorders are Gener...
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| Formato: | Dissertação |
| Idioma: | pt_BR |
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Brasil
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| Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/27860 |
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| Resumo: | Introduction: Anxiety is a disorder that has been affecting a substantial number of individuals,
presenting a prevalence of 9.3% of people affected in Brazil, being the country with the highest
prevalence of this pathology among the countries of the Americas. Among the anxiety disorders are
Generalized Anxiety Disorder (GAD), characterized mainly by tremors, muscular hypotonia,
hyperventilation, sweating, palpitations, apprehension, restlessness, distractibility, loss of
concentration and insomnia, causing impairment in the functional, social, affective and cognitive life
of the individual, thus, there is a need for an effective treatment that can minimize these effects that
GAD brings to affected individuals. One of the techniques that has been used with positive results for
treatments of some psychiatric disorders is Transcranial Direct Current Stimulation (TDCS), which is
a noninvasive neuromodulation technique that, through a 1 to 1 electric microcurrent 2 mA causes
stimulation or inhibition of neuronal activity. This stimulation causes specific changes in the behavior
and motor activity of individuals by modulating specific areas of the brain. Despite many studies of
TDCS in mood disorders, such as depression, and some studies in anxiety disorders such as panic,
TDCS studies with GAD are still incipient. Thus, there is a need to evaluate the effects that TDCS can
have on people affected by GAD, which is a recurrent disorder in society. Objectives: To analyze the
effects of TDCS in people affected by GAD, presenting possible improvements in the symptoms of the
disease. Materials and methods: The study will be based on a Triple-Blind Randomized Clinical Trial,
with a sample of 30 participants, of both sexes, aged between 20 and 40 years, who had the clinical
diagnosis of GAD, according to the criteria of the American Psychiatric Association (DSM-V) and was
performed at Climaf (Mossoró-RN), in a reserved and restricted place. Participants were divided into
two groups, sham (placebo) and experiment, and the allocation was performed in a randomized, doubleblind fashion. The instruments used to assess anxiety were BAI and the Hamilton Scale. For the
evaluation of depressive symptoms, BDI. For stress symptoms, Lipp's stress inventory. And for
assessment of affectivity, the PANAS scale. Parametric tests were used, with a significance level of
p≤0.05. Results: No differences were found for the primary and secondary outcomes. However, a
significantly greater improvement was found in the active group for the physical symptoms of stress.
Although intragroup analyzes showed decreases in anxiety, stress, negative affectivity, and depression
scores, no intergroup comparison showed significant difference. Improvement in physical aspects of
GAD stress can improve life satisfaction, cognitive function, and psychological well-being.
Conclusion: The main results of this placebo-controlled study indicate that five sessions of anodic
ECCT on Dorsolateral Frontal Frontex did not improve anxiety and mood symptoms in patients with
GAD. However, the protocol showed improvement in the physical symptoms of stress. |
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