Gain of transcription factor binding sites is associated to changes in the expression signature of human brain and testis and is correlated to genes with higher expression breadth

The gain of transcription factor binding sites (TFBS) is believed to represent one of the major causes of biological innovation. Here we used strategies based on comparative genomics to identify 21,822 TFBS specific to the human lineage (TFBS-HS), when compared to chimpanzee and gorilla genomes. Mor...

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Principais autores: Silva, Vandeclécio Lira da, Santos, André Mauricio Ribeiro dos, Blanco, Wilfredo, Souza, Sandro José de
Formato: article
Idioma:English
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Assuntos:
Transcription Factor Binding Sites (TFBS)
transcript factor
human evolution
expression breadth
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/26960
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spelling ri-123456789-269602019-05-26T06:08:17Z Gain of transcription factor binding sites is associated to changes in the expression signature of human brain and testis and is correlated to genes with higher expression breadth Silva, Vandeclécio Lira da Santos, André Mauricio Ribeiro dos Blanco, Wilfredo Souza, Sandro José de Transcription Factor Binding Sites (TFBS) transcript factor human evolution expression breadth The gain of transcription factor binding sites (TFBS) is believed to represent one of the major causes of biological innovation. Here we used strategies based on comparative genomics to identify 21,822 TFBS specific to the human lineage (TFBS-HS), when compared to chimpanzee and gorilla genomes. More than 40% (9,206) of these TFBS-HS are in the vicinity of 1,283 genes. A comparison of the expression pattern of these genes and the corresponding orthologs in chimpanzee and gorilla identified genes differentially expressed in human tissues. These genes show a more divergent expression pattern in the human testis and brain, suggesting a role for positive selection in the fixation of TFBS gains. Genes associated with TFBS-HS were enriched in gene ontology categories related to transcriptional regulation, signaling, differentiation/development and nervous system. Furthermore, genes associated with TFBS-HS present a higher expression breadth when compared to genes in general. This biased distribution is due to a preferential gain of TFBS in genes with higher expression breadth rather than a shift in the expression pattern after the gain of TFBS. 2019-04-23T14:10:50Z 2019-04-23T14:10:50Z 2019-03-22 article SILVA, V. L. et al. Gain of transcription factor binding sites is associated to changes in the expression signature of human brain and testis and is correlated to genes with higher expression breadth. Sci. China Life Sci. v. 62, p. 526, mar. 2019. doi: 10.1007/s11427-018-9454-7 https://repositorio.ufrn.br/jspui/handle/123456789/26960 10.1007/s11427-018-9454-7 en application/pdf
institution Repositório Institucional
collection RI - UFRN
language English
topic Transcription Factor Binding Sites (TFBS)
transcript factor
human evolution
expression breadth
spellingShingle Transcription Factor Binding Sites (TFBS)
transcript factor
human evolution
expression breadth
Silva, Vandeclécio Lira da
Santos, André Mauricio Ribeiro dos
Blanco, Wilfredo
Souza, Sandro José de
Gain of transcription factor binding sites is associated to changes in the expression signature of human brain and testis and is correlated to genes with higher expression breadth
description The gain of transcription factor binding sites (TFBS) is believed to represent one of the major causes of biological innovation. Here we used strategies based on comparative genomics to identify 21,822 TFBS specific to the human lineage (TFBS-HS), when compared to chimpanzee and gorilla genomes. More than 40% (9,206) of these TFBS-HS are in the vicinity of 1,283 genes. A comparison of the expression pattern of these genes and the corresponding orthologs in chimpanzee and gorilla identified genes differentially expressed in human tissues. These genes show a more divergent expression pattern in the human testis and brain, suggesting a role for positive selection in the fixation of TFBS gains. Genes associated with TFBS-HS were enriched in gene ontology categories related to transcriptional regulation, signaling, differentiation/development and nervous system. Furthermore, genes associated with TFBS-HS present a higher expression breadth when compared to genes in general. This biased distribution is due to a preferential gain of TFBS in genes with higher expression breadth rather than a shift in the expression pattern after the gain of TFBS.
format article
author Silva, Vandeclécio Lira da
Santos, André Mauricio Ribeiro dos
Blanco, Wilfredo
Souza, Sandro José de
author_facet Silva, Vandeclécio Lira da
Santos, André Mauricio Ribeiro dos
Blanco, Wilfredo
Souza, Sandro José de
author_sort Silva, Vandeclécio Lira da
title Gain of transcription factor binding sites is associated to changes in the expression signature of human brain and testis and is correlated to genes with higher expression breadth
title_short Gain of transcription factor binding sites is associated to changes in the expression signature of human brain and testis and is correlated to genes with higher expression breadth
title_full Gain of transcription factor binding sites is associated to changes in the expression signature of human brain and testis and is correlated to genes with higher expression breadth
title_fullStr Gain of transcription factor binding sites is associated to changes in the expression signature of human brain and testis and is correlated to genes with higher expression breadth
title_full_unstemmed Gain of transcription factor binding sites is associated to changes in the expression signature of human brain and testis and is correlated to genes with higher expression breadth
title_sort gain of transcription factor binding sites is associated to changes in the expression signature of human brain and testis and is correlated to genes with higher expression breadth
publishDate 2019
url https://repositorio.ufrn.br/jspui/handle/123456789/26960
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AT blancowilfredo gainoftranscriptionfactorbindingsitesisassociatedtochangesintheexpressionsignatureofhumanbrainandtestisandiscorrelatedtogeneswithhigherexpressionbreadth
AT souzasandrojosede gainoftranscriptionfactorbindingsitesisassociatedtochangesintheexpressionsignatureofhumanbrainandtestisandiscorrelatedtogeneswithhigherexpressionbreadth
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