Investigação das alterações da subpopulação lifocitária no sangue periférico em mulheres com papilomavírus humano de alto risco oncogênico
Cervical cancer is a problem of great social relevance, since it is the second most common gynecological malignancy in the world. The main precursor of cervical cancer is human papillomavirus (HPV) infection. Despite the great advances in the biology of HPV, little is known about the immune respo...
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| Formato: | doctoralThesis |
| Idioma: | pt_BR |
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Brasil
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| Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/26764 |
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| Resumo: | Cervical cancer is a problem of great social relevance, since it is the second
most common gynecological malignancy in the world. The main precursor of cervical
cancer is human papillomavirus (HPV) infection. Despite the great advances in the
biology of HPV, little is known about the immune response to this virus. Human
papillomavirus (HPV) is associated with cervical carcinogenesis through
epidemiological and laboratory evidence. HPV infections occur in women all over the
world. The search for potential prognostic markers, aiming at understanding the
progression of intraepithelial lesions is of paramount importance. It is believed that
immunoregulatory, immunogenic and cell cycle proteins are closely involved in the
process of carcinogenesis. For this reason, the early detection of this type of infection
is of great importance. Considering the above, the initial proposal of the project was
to evaluate the systemic immune profile of patients with HPV virus. Initially, oncotic
cytology tests were performed to screen patients who were carriers of HPV viruses,
followed by the hybrid capture and polymerase chain reaction (PCR) to typify the
virus, subsequently the immunophenotyping of these patients to evaluate the
immunological profile, quantifying the lymphocytes (CD4, CD8, NK and NKT cells). It
was evidenced a relative increase of the CD8 + T lymphocytes in patients with high
oncogenic HPV and an expressive decrease of the NK and NKT cells, independent
of HPV oncogenicity. Our study is registered in the ethics and research committee of
the university hospital Onofre Lopes (CEP-HUOL), number 097/07. Subsequently,
we performed a systematic review of the immunohistochemical expression of p16, ki67 and p53 in patients with cervical lesions, obtaining as a result a greater
expression of these markers according to the severity of the lesions, being able to be
considered valuable biomarkers to discriminate the stages of progressive cervical
lesions. |
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