Alcaloides de Selaginella convoluta: investigação química e do potencial antifúngico
Selaginella convoluta is native from Brazil semi-arid and has shown interesting use in folk medicine, therefore there is a potentiality of obtaining bioactive molecules from this species. The aim of this study is the phytochemistry of S. convoluta by structural identification of its alkaloids, as...
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| Formato: | Dissertação |
| Idioma: | pt_BR |
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Brasil
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| Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/26690 |
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| Resumo: | Selaginella convoluta is native from Brazil semi-arid and has shown interesting
use in folk medicine, therefore there is a potentiality of obtaining bioactive molecules
from this species. The aim of this study is the phytochemistry of S. convoluta by structural
identification of its alkaloids, as well as an investigation of the metabolism in the dry and
irrigated conditions. Also, biological potential of the enriched fraction of alkaloids against
yeast was evaluated. The NMR technique was used for structure elucidation and analysis
of the metabolic fingerprint. NMR spectra of the metabolic fingerprint analysis were
analyzed according to Pearson correlation. The metabolites identified in metabolic
fingerprint analysis that demonstrated to be interesting under the point of view of the
biosynthesis are inositol and glutamate. Inositol appears to be more present in irrigated
condition and has zero correlation coefficient, which indicates a significant difference
between the analyzed conditions, according to the Pearson correlation. Inositol can be
combined with auxin, allowing the long-distance transport within the plant. Whereas
glutamate appear to be more present in the dry condition, having a coefficient 0.5 ≤ or
<0.8, indicating a moderate correlation. The glutamate has an important role in
communications over long distances, being a precursor of substances such as proline,
GABA and polyamines, substances involved in drought tolerance and which has an
important role in the stress response in plants. On this way, inositol and glutamate
demonstrated importance from the point of view of the biosynthesis, once may to be
involved in the communication between the roots and the aerial parts of S. convoluta.
Furthermore, anabasine, a pyridine alkaloid was identified for the first time in
Selaginellaceae, and also in pteridophytes. The anabasine presented potential antifungal
properties against Candida krusei and Cryptococcus neoformans. |
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