Nanoemulsão estabilizada por hidrofobina, um carreador promissor para nutracêuticos
Hydrophobin II (HFBII) is an amphiphilic biopolymer that could be explored to stabilize oil-in-water nanoemulsions as nutraceutical delivery systems. This study reports the production of HFBII-stabilized nanoemulsions by a spontaneous emulsification process using copaiba oil as a bioactive lipid....
Na minha lista:
| Autor principal: | |
|---|---|
| Outros Autores: | |
| Formato: | Dissertação |
| Idioma: | por |
| Publicado em: |
Brasil
|
| Assuntos: | |
| Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/26540 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|
| Resumo: | Hydrophobin II (HFBII) is an amphiphilic biopolymer that could be explored to
stabilize oil-in-water nanoemulsions as nutraceutical delivery systems. This study
reports the production of HFBII-stabilized nanoemulsions by a spontaneous
emulsification process using copaiba oil as a bioactive lipid. HFBII was isolated from
a wild-type Trichoderma reesei and characterized. A 23
full factorial design with three
central points was used to obtain an optimal nanoemulsion system, whose physicalchemical properties were studied under different ionic strength and pH. The peptide
similarity search allowed the identification of a series of 6 ion fragments from the
isolated fraction, which can be attributed to the amino acid sequences of the HFBII
database. The optimal nanoemulsion system presented a nanoscale droplet size
(<200 nm), a narrow size distribution (PDI <0.2) and a zeta potential of ≈ -30 mV,
which was stable at low salt content and pH values close to the neutrality. These
results demonstrated the feasibility of using HFBII as a biopolymer to stabilize
nanoemulsion systems. Furthermore, the HFBII-stabilized nanoemulsion is a
promising carrier for nutraceuticals in food technology applications. |
|---|