Delivery of differentiation factors by mesoporous silica particles assists advanced differentiation of transplanted murine embryonic stem cells
Stem cell transplantation holds great hope for the replacement of damaged cells in the nervous system. However, poor long-term survival after transplantation and insufficiently robust differentiation of stem cells into specialized cell types in vivo remain major obstacles for clinical application. H...
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ri-123456789-261772021-07-09T21:18:47Z Delivery of differentiation factors by mesoporous silica particles assists advanced differentiation of transplanted murine embryonic stem cells Garcia-Bennett, Alfonso E. Kozhevnikova, Mariya König, Niclas Zhou, Chunfang Leão, Richardson Naves Knöpfel, Thomas Pankratova, Stanislava Trolle, Carl Berezin, Vladimir Bock, Elisabeth Aldskogius, Håkan Kozlova, Elena N. Cell transplantation Differentiation Embryonic stem cells Nervous system Neural differentiation Neural stem cell Stem cell culture Transplantation Stem cell transplantation holds great hope for the replacement of damaged cells in the nervous system. However, poor long-term survival after transplantation and insufficiently robust differentiation of stem cells into specialized cell types in vivo remain major obstacles for clinical application. Here, we report the development of a novel technological approach for the local delivery of exogenous trophic factor mimetics to transplanted cells using specifically designed silica nanoporous particles. We demonstrated that delivering Cintrofin and Gliafin, established peptide mimetics of the ciliary neurotrophic factor and glial cell line-derived neurotrophic factor, respectively, with these particles enabled not only robust functional differentiation of motor neurons from transplanted embryonic stem cells but also their long-term survival in vivo. We propose that the delivery of growth factors by mesoporous nanoparticles is a potentially versatile and widely applicable strategy for efficient differentiation and functional integration of stem cell derivatives upon transplantation. 2018-11-26T17:37:44Z 2018-11-26T17:37:44Z 2013 article GARCIA-BENNETT, A. E. et al. Delivery of differentiation factors by mesoporous silica particles assists advanced differentiation of transplanted murine embryonic stem cells. Send to Stem Cells Transl Med., v. 2, n. 11, p. 905-915, 2013. DOI: 10.5966/sctm.2013-0072 https://repositorio.ufrn.br/jspui/handle/123456789/26177 10.5966/sctm.2013-0072 eng Acesso Aberto application/pdf |
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eng |
| topic |
Cell transplantation Differentiation Embryonic stem cells Nervous system Neural differentiation Neural stem cell Stem cell culture Transplantation |
| spellingShingle |
Cell transplantation Differentiation Embryonic stem cells Nervous system Neural differentiation Neural stem cell Stem cell culture Transplantation Garcia-Bennett, Alfonso E. Kozhevnikova, Mariya König, Niclas Zhou, Chunfang Leão, Richardson Naves Knöpfel, Thomas Pankratova, Stanislava Trolle, Carl Berezin, Vladimir Bock, Elisabeth Aldskogius, Håkan Kozlova, Elena N. Delivery of differentiation factors by mesoporous silica particles assists advanced differentiation of transplanted murine embryonic stem cells |
| description |
Stem cell transplantation holds great hope for the replacement of damaged cells in the nervous system. However, poor long-term survival after transplantation and insufficiently robust differentiation of stem cells into specialized cell types in vivo remain major obstacles for clinical application. Here, we report the development of a novel technological approach for the local delivery of exogenous trophic factor mimetics to transplanted cells using specifically designed silica nanoporous particles. We demonstrated that delivering Cintrofin and Gliafin, established peptide mimetics of the ciliary neurotrophic factor and glial cell line-derived neurotrophic factor, respectively, with these particles enabled not only robust functional differentiation of motor neurons from transplanted embryonic stem cells but also their long-term survival in vivo. We propose that the delivery of growth factors by mesoporous nanoparticles is a potentially versatile and widely applicable strategy for efficient differentiation and functional integration of stem cell derivatives upon transplantation. |
| format |
article |
| author |
Garcia-Bennett, Alfonso E. Kozhevnikova, Mariya König, Niclas Zhou, Chunfang Leão, Richardson Naves Knöpfel, Thomas Pankratova, Stanislava Trolle, Carl Berezin, Vladimir Bock, Elisabeth Aldskogius, Håkan Kozlova, Elena N. |
| author_facet |
Garcia-Bennett, Alfonso E. Kozhevnikova, Mariya König, Niclas Zhou, Chunfang Leão, Richardson Naves Knöpfel, Thomas Pankratova, Stanislava Trolle, Carl Berezin, Vladimir Bock, Elisabeth Aldskogius, Håkan Kozlova, Elena N. |
| author_sort |
Garcia-Bennett, Alfonso E. |
| title |
Delivery of differentiation factors by mesoporous silica particles assists advanced differentiation of transplanted murine embryonic stem cells |
| title_short |
Delivery of differentiation factors by mesoporous silica particles assists advanced differentiation of transplanted murine embryonic stem cells |
| title_full |
Delivery of differentiation factors by mesoporous silica particles assists advanced differentiation of transplanted murine embryonic stem cells |
| title_fullStr |
Delivery of differentiation factors by mesoporous silica particles assists advanced differentiation of transplanted murine embryonic stem cells |
| title_full_unstemmed |
Delivery of differentiation factors by mesoporous silica particles assists advanced differentiation of transplanted murine embryonic stem cells |
| title_sort |
delivery of differentiation factors by mesoporous silica particles assists advanced differentiation of transplanted murine embryonic stem cells |
| publishDate |
2018 |
| url |
https://repositorio.ufrn.br/jspui/handle/123456789/26177 |
| work_keys_str_mv |
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