Perfil endócrino e comportamental de sagui comum (Callithrix jacchus) em idade jovem no grupo familiar e durante isolamento social
Common marmoset, Callithrix jacchus, is a New World primate considered an important experimental model. Until very recently, most of the studies have been performed using adult marmosets in different areas of interest, such as genetics, metabolism and, mainly, neurosciences. The study of the stre...
Na minha lista:
| Autor principal: | |
|---|---|
| Outros Autores: | |
| Formato: | Dissertação |
| Idioma: | por |
| Publicado em: |
Brasil
|
| Assuntos: | |
| Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/26140 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|
| Resumo: | Common marmoset, Callithrix jacchus, is a New World primate considered an important
experimental model. Until very recently, most of the studies have been performed using
adult marmosets in different areas of interest, such as genetics, metabolism and, mainly,
neurosciences. The study of the stress response in this model has also produced relevant
information, where mature males and females present a behavioral and endocrine
dimorphic response. In the perspective of current models for depression and considering
the high prevalence of 18% of this neuropsychiatric disorder in the human population,
and around 14% in adolescents, the use of these animals during development is in the
initial phase of research. Therefore, studies with immature animals are necessary to
validate this experimental model in the early stages of its development. The objective of
this study was to describe the hormonal and behavioral changes in immature males and
females within family group and during social isolation. Twenty-nine animals with ages
of 6 (n = 8, 4 males), 9 (n = 10, 5 males) and 12 (n = 11; 5 males) were used, where data
collection occurred in the family group (baseline), in the first 2 days (FEI) and in the last
two days (FEF) after separation for 3 weeks, and two days after the animal returned to
the family group (reunion). Females presented significant changes in cortisol at 3 studied
ages and males responded by increasing cortisol faster than females at 9 months, while
cortisol elevation at this age in females occurred at the final stage of the separation period.
The behavior of the females showed significant differences in the autogrooming in
relation to that of males and the behavior of scent marking showed an increasing profile
with the age of both males and females. The food intake behavior, modulated by the
hypothalamic-pituitary-adrenal (HPA) axis, showed a decrease in the final phase of the
study in females and needs to be investigated in males. These results indicate the potential
of early-age common marmosets as an important experimental model when exposed to
psychiatric disorders in adolescence, and emphasizes that researchers should be alert to
sex and age of the animals during the development of protocols for their use as
experimental models. |
|---|