Salicylate induces anxiety-like behaviour and slow theta oscillation and abolishes the relationship between running speed and fast theta oscillation frequency

Salicylate intoxication is a cause of tinnitus in humans and it is often used to produce tinnitus‐like perception in animal models. Here we assess whether salicylate induces anxiety‐like electrophysiological and behavioural signs. Using microwire electrode arrays, we recorded local field potential i...

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Principais autores: Winne, Jessica, Franzon, Rafael, Miranda, Aron, Malfatti, Thawann, Patriota, João, Mikulovic, Sanja, Leão, Emelie Katarina Svahn, Leão, Richardson Naves
Formato: article
Idioma:eng
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Assuntos:
Salicylate
anxiety
theta
tinnitus
ventral hippocampus
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/25918
https://doi.org/10.1002/hipo.23021
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spelling ri-123456789-259182022-10-18T21:21:47Z Salicylate induces anxiety-like behaviour and slow theta oscillation and abolishes the relationship between running speed and fast theta oscillation frequency Winne, Jessica Franzon, Rafael Miranda, Aron Malfatti, Thawann Patriota, João Mikulovic, Sanja Leão, Emelie Katarina Svahn Leão, Richardson Naves Salicylate anxiety theta tinnitus ventral hippocampus Salicylate intoxication is a cause of tinnitus in humans and it is often used to produce tinnitus‐like perception in animal models. Here we assess whether salicylate induces anxiety‐like electrophysiological and behavioural signs. Using microwire electrode arrays, we recorded local field potential in the ventral and, in some experiments dorsal hippocampus, in an open field arena 1 hour after salicylate (300mg/kg) injection. We found that animals treated with salicylate moved dramatically less than saline treated animals. Salicylate‐treated animals showed a strong 4‐6Hz (type 2) oscillation in the ventral hippocampus (with smaller peaks in dorsal hippocampus electrodes). Coherence in the 4‐6Hz‐theta band was low in the ventral and dorsal hippocampus when compared to movement‐related theta coherence (7‐10Hz). Moreover, movement related theta oscillation frequency decreased and its dependency on running speed was abolished. Our results suggest that salicylate‐induced theta is mostly restricted to the ventral hippocampus. Slow theta has been classically associated to anxiety‐like behaviours. Here we show that salicylate application can consistently generate low frequency theta in the ventral hippocampus. Tinnitus and anxiety show strong comorbidity and the increase in ventral hippocampus low frequency theta could be part of this association. 2018-09-28T16:24:28Z 2018-09-28T16:24:28Z 2018-08-28 article Winne J, Franzon R, Miranda A, Malfatti T, Patriota J, Mikulovic S, Leão KE, Leão RN. Salicylate induces anxiety-like behaviour and slow theta oscillation and abolishes the relationship between running speed and fast theta oscillation frequency. Hippocampus. 2018 Aug 28. doi: 10.1002/hipo.23021. [Epub ahead of print] https://repositorio.ufrn.br/jspui/handle/123456789/25918 https://doi.org/10.1002/hipo.23021 eng Acesso Aberto
institution Repositório Institucional
collection RI - UFRN
language eng
topic Salicylate
anxiety
theta
tinnitus
ventral hippocampus
spellingShingle Salicylate
anxiety
theta
tinnitus
ventral hippocampus
Winne, Jessica
Franzon, Rafael
Miranda, Aron
Malfatti, Thawann
Patriota, João
Mikulovic, Sanja
Leão, Emelie Katarina Svahn
Leão, Richardson Naves
Salicylate induces anxiety-like behaviour and slow theta oscillation and abolishes the relationship between running speed and fast theta oscillation frequency
description Salicylate intoxication is a cause of tinnitus in humans and it is often used to produce tinnitus‐like perception in animal models. Here we assess whether salicylate induces anxiety‐like electrophysiological and behavioural signs. Using microwire electrode arrays, we recorded local field potential in the ventral and, in some experiments dorsal hippocampus, in an open field arena 1 hour after salicylate (300mg/kg) injection. We found that animals treated with salicylate moved dramatically less than saline treated animals. Salicylate‐treated animals showed a strong 4‐6Hz (type 2) oscillation in the ventral hippocampus (with smaller peaks in dorsal hippocampus electrodes). Coherence in the 4‐6Hz‐theta band was low in the ventral and dorsal hippocampus when compared to movement‐related theta coherence (7‐10Hz). Moreover, movement related theta oscillation frequency decreased and its dependency on running speed was abolished. Our results suggest that salicylate‐induced theta is mostly restricted to the ventral hippocampus. Slow theta has been classically associated to anxiety‐like behaviours. Here we show that salicylate application can consistently generate low frequency theta in the ventral hippocampus. Tinnitus and anxiety show strong comorbidity and the increase in ventral hippocampus low frequency theta could be part of this association.
format article
author Winne, Jessica
Franzon, Rafael
Miranda, Aron
Malfatti, Thawann
Patriota, João
Mikulovic, Sanja
Leão, Emelie Katarina Svahn
Leão, Richardson Naves
author_facet Winne, Jessica
Franzon, Rafael
Miranda, Aron
Malfatti, Thawann
Patriota, João
Mikulovic, Sanja
Leão, Emelie Katarina Svahn
Leão, Richardson Naves
author_sort Winne, Jessica
title Salicylate induces anxiety-like behaviour and slow theta oscillation and abolishes the relationship between running speed and fast theta oscillation frequency
title_short Salicylate induces anxiety-like behaviour and slow theta oscillation and abolishes the relationship between running speed and fast theta oscillation frequency
title_full Salicylate induces anxiety-like behaviour and slow theta oscillation and abolishes the relationship between running speed and fast theta oscillation frequency
title_fullStr Salicylate induces anxiety-like behaviour and slow theta oscillation and abolishes the relationship between running speed and fast theta oscillation frequency
title_full_unstemmed Salicylate induces anxiety-like behaviour and slow theta oscillation and abolishes the relationship between running speed and fast theta oscillation frequency
title_sort salicylate induces anxiety-like behaviour and slow theta oscillation and abolishes the relationship between running speed and fast theta oscillation frequency
publishDate 2018
url https://repositorio.ufrn.br/jspui/handle/123456789/25918
https://doi.org/10.1002/hipo.23021
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AT mirandaaron salicylateinducesanxietylikebehaviourandslowthetaoscillationandabolishestherelationshipbetweenrunningspeedandfastthetaoscillationfrequency
AT malfattithawann salicylateinducesanxietylikebehaviourandslowthetaoscillationandabolishestherelationshipbetweenrunningspeedandfastthetaoscillationfrequency
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AT mikulovicsanja salicylateinducesanxietylikebehaviourandslowthetaoscillationandabolishestherelationshipbetweenrunningspeedandfastthetaoscillationfrequency
AT leaoemeliekatarinasvahn salicylateinducesanxietylikebehaviourandslowthetaoscillationandabolishestherelationshipbetweenrunningspeedandfastthetaoscillationfrequency
AT leaorichardsonnaves salicylateinducesanxietylikebehaviourandslowthetaoscillationandabolishestherelationshipbetweenrunningspeedandfastthetaoscillationfrequency
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