Obtenção de fitas cerâmicas baseadas em paligorskita/PVA via tape casting como veículo para neomicina
There are several efforts to develop nanocomposites that present the combination of organic polymer networks and bioactive inorganic nanoparticles for wound healing. Palygorskite has been extensively applied in drug delivery systems because it has interesting physical chemical properties. Neomyci...
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| Formato: | Dissertação |
| Idioma: | por |
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| Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/25768 |
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| Resumo: | There are several efforts to develop nanocomposites that present the combination of
organic polymer networks and bioactive inorganic nanoparticles for wound healing.
Palygorskite has been extensively applied in drug delivery systems because it has
interesting physical chemical properties. Neomycin has been considered an active
principle indicated for the treatment of open wounds, which acts to inhibit the protein
synthesis of Gram-negative and Gram-positive bacteria. Tape casting is a technique
widely used in the production of flat thin films with high specific area. In this work,
ceramic tapes based on palygorskite, the drug neomycin, and the PVA were obtained
in order to investigate the controlled release of drug for topical administration. The
stability of the suspension was analyzed by rheological tests, and the powders and
ceramic tapes were characterized by X-ray fluorescence (XRF), X-ray diffraction
(XRD), thermal analysis (TGA/DTA), differential scanning calorimetry (DSC), Fourier
transform infrared spectroscopy (FTIR), elemental analysis (CHN-S), scanning
electron microscopy (SEM-FEG). Tests of antimicrobial activity and minimum
bactericidal concentration were performed in order to investigate the potential for
drug inhibition in the sheets. Finally, equations of classical mechanics were carried
out in order to estimate the energy, for possible calculation of adsorption energy.
According to the rheology results, a pseudoplastic behavior was observed, suitable
for the tape casting technique. Reflection peaks related to the palygorskite phases, of
orthorhombic structure and quartz, of hexagonal structure were found. DSC analysis
identified exothermic peaks characteristic of neomycin in the Pal-Neo hybrid.
Elemental analysis results showed that less than 3% of neomycin was incorporated
into palygorskite. Tests of antimicrobial activity and minimum bactericidal
concentration demonstrated that the Pal-Neo hybrid had an inhibitory effect on the
growth of bacteria, proving being capable of damaging the cytoplasmic membrane of
the tested bacteria. |
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