Olmesartan Prevented Intra-articular Inflammation Induced by Zymosan in Rats

The objective of this study was to study the effect of olmesartan medoxomil (OLM), an antihypertensive drug, on intra-articular inflammation induced by zymosan (Zy) in Wistar rats. Intra-articular inflammation was induced in the right knees of rats by 1 mg Zy dissolved in saline. The animals were di...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Principais autores: Araújo, Aurigena Antunes de, Guerra, Gerlane Coelho Bernardo, Menezes, Marília Stefani Souza de, Araújo Júnior, Raimundo Fernandes de, Medeiros, Caroline Addison Carvalho Xavier de
Formato: article
Idioma:eng
Publicado em: The Pharmaceutical Society of Japan
Assuntos:
Olmesartan
Zymosan
Intra-articular inflammation
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/25431
https://doi.org/10.1248/bpb.b16-00296
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
id ri-123456789-25431
record_format dspace
spelling ri-123456789-254312021-11-11T19:12:48Z Olmesartan Prevented Intra-articular Inflammation Induced by Zymosan in Rats Araújo, Aurigena Antunes de Guerra, Gerlane Coelho Bernardo Menezes, Marília Stefani Souza de Araújo Júnior, Raimundo Fernandes de Medeiros, Caroline Addison Carvalho Xavier de Olmesartan Zymosan Intra-articular inflammation The objective of this study was to study the effect of olmesartan medoxomil (OLM), an antihypertensive drug, on intra-articular inflammation induced by zymosan (Zy) in Wistar rats. Intra-articular inflammation was induced in the right knees of rats by 1 mg Zy dissolved in saline. The animals were divided into the following groups: saline only (oral saline and intra-articular saline); Zy only (intra-articular Zy and oral saline), and intra-articular Zy and oral OLM (5, 15, or 30 mg/kg) or diclofenac sodium (SD; 100 mg/kg). Twenty-four hours after Zy injection, synovial fluid was collected for total leukocyte counts, blood was collected for biochemical measurements, and synovial tissue was collected for histopathology, immunohistochemistry, immunofluorescence and myeloperoxidase (MPO), malonaldehyde (MDA), and non-protein sulphydryl (NPSH) assays. OLM doses of 15 and 30 mg/kg had protective effects, as evidenced by improved histopathological parameters of synovium, reduced total leukocyte counts, reduced MPO and MDA levels, and increased NPSH group levels compared with the Zy group. OLM reduced immunostaining for cyclooxygenase 2, tumour necrosis factor and interleukin 17 and increased immunostaining for superoxide dismutase and glutathione peroxidase. SD produced similar results. The drugs studied caused no change in biochemical parameters of the animals. OLM showed protective effects in this model of Zy-induced intra-articular inflammation. 2018-06-16T13:41:17Z 2018-06-16T13:41:17Z 2016 article ARAÚJO, Aurigena Antunes de et al. Olmesartan Prevented Intra-articular Inflammation Induced by Zymosan in Rats. Biological & Pharmaceutical Bulletin, v. 39, p. 1793-1801, 2016. Disponível em: <https://www.jstage.jst.go.jp/article/bpb/39/11/39_b16-00296/_article>. Acesso em: 20 mar. 2018. 1347-5215 https://repositorio.ufrn.br/jspui/handle/123456789/25431 https://doi.org/10.1248/bpb.b16-00296 eng Acesso Aberto application/pdf The Pharmaceutical Society of Japan
institution Repositório Institucional
collection RI - UFRN
language eng
topic Olmesartan
Zymosan
Intra-articular inflammation
spellingShingle Olmesartan
Zymosan
Intra-articular inflammation
Araújo, Aurigena Antunes de
Guerra, Gerlane Coelho Bernardo
Menezes, Marília Stefani Souza de
Araújo Júnior, Raimundo Fernandes de
Medeiros, Caroline Addison Carvalho Xavier de
Olmesartan Prevented Intra-articular Inflammation Induced by Zymosan in Rats
description The objective of this study was to study the effect of olmesartan medoxomil (OLM), an antihypertensive drug, on intra-articular inflammation induced by zymosan (Zy) in Wistar rats. Intra-articular inflammation was induced in the right knees of rats by 1 mg Zy dissolved in saline. The animals were divided into the following groups: saline only (oral saline and intra-articular saline); Zy only (intra-articular Zy and oral saline), and intra-articular Zy and oral OLM (5, 15, or 30 mg/kg) or diclofenac sodium (SD; 100 mg/kg). Twenty-four hours after Zy injection, synovial fluid was collected for total leukocyte counts, blood was collected for biochemical measurements, and synovial tissue was collected for histopathology, immunohistochemistry, immunofluorescence and myeloperoxidase (MPO), malonaldehyde (MDA), and non-protein sulphydryl (NPSH) assays. OLM doses of 15 and 30 mg/kg had protective effects, as evidenced by improved histopathological parameters of synovium, reduced total leukocyte counts, reduced MPO and MDA levels, and increased NPSH group levels compared with the Zy group. OLM reduced immunostaining for cyclooxygenase 2, tumour necrosis factor and interleukin 17 and increased immunostaining for superoxide dismutase and glutathione peroxidase. SD produced similar results. The drugs studied caused no change in biochemical parameters of the animals. OLM showed protective effects in this model of Zy-induced intra-articular inflammation.
format article
author Araújo, Aurigena Antunes de
Guerra, Gerlane Coelho Bernardo
Menezes, Marília Stefani Souza de
Araújo Júnior, Raimundo Fernandes de
Medeiros, Caroline Addison Carvalho Xavier de
author_facet Araújo, Aurigena Antunes de
Guerra, Gerlane Coelho Bernardo
Menezes, Marília Stefani Souza de
Araújo Júnior, Raimundo Fernandes de
Medeiros, Caroline Addison Carvalho Xavier de
author_sort Araújo, Aurigena Antunes de
title Olmesartan Prevented Intra-articular Inflammation Induced by Zymosan in Rats
title_short Olmesartan Prevented Intra-articular Inflammation Induced by Zymosan in Rats
title_full Olmesartan Prevented Intra-articular Inflammation Induced by Zymosan in Rats
title_fullStr Olmesartan Prevented Intra-articular Inflammation Induced by Zymosan in Rats
title_full_unstemmed Olmesartan Prevented Intra-articular Inflammation Induced by Zymosan in Rats
title_sort olmesartan prevented intra-articular inflammation induced by zymosan in rats
publisher The Pharmaceutical Society of Japan
publishDate 2018
url https://repositorio.ufrn.br/jspui/handle/123456789/25431
https://doi.org/10.1248/bpb.b16-00296
work_keys_str_mv AT araujoaurigenaantunesde olmesartanpreventedintraarticularinflammationinducedbyzymosaninrats
AT guerragerlanecoelhobernardo olmesartanpreventedintraarticularinflammationinducedbyzymosaninrats
AT menezesmariliastefanisouzade olmesartanpreventedintraarticularinflammationinducedbyzymosaninrats
AT araujojuniorraimundofernandesde olmesartanpreventedintraarticularinflammationinducedbyzymosaninrats
AT medeiroscarolineaddisoncarvalhoxavierde olmesartanpreventedintraarticularinflammationinducedbyzymosaninrats
_version_ 1773959724557926400

Registros relacionados