Lifestyle and family history influence cancer prognosis in Brazilian individuals
The aim of this research was to study prognostic parameters of CRC by analyzing clinical and pathological variables associated with cancer patients at a northeastern Brazilian Hospital. This was a retrospective study evaluating CRC-diagnosed patients across a 10-year period (1995–2005) at Dr. Lui...
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ri-123456789-254142021-11-11T20:04:38Z Lifestyle and family history influence cancer prognosis in Brazilian individuals Araújo, Aurigena Antunes de Araújo Jr, Raimundo F. Lira, George A. Guedes, Hugo G. Cardoso, Marília A. Cavalcante, Francisco J. Araújo, Ana Lucia M. Ramos, Carlos César O. Colorectal cancer Brazil Survival Neoplasm by site Public health The aim of this research was to study prognostic parameters of CRC by analyzing clinical and pathological variables associated with cancer patients at a northeastern Brazilian Hospital. This was a retrospective study evaluating CRC-diagnosed patients across a 10-year period (1995–2005) at Dr. Luiz Antônio Hospital in Natal, RN, Brazil. Data were collected from patients’ medical files. A total of 358 patients were included over the 10-year period. The average age at diagnosis was 58.8 years (S.D. = 15.26), 48.3% of the patients were males and 51.7% were females. Alcohol consumption significantly increased the chance of dying (p < 0.023) from colorectal cancer; this increased risk of death was approximately 71%, compared to 52.2% of the non-alcoholics. In addition, tobacco increased the chance of developing high TNM stage tumors (level III, IV; p < 0.001). Another risk factor for increased mortality was a family history for colorectal cancer (p < 0.002). Our analysis found that patients with an unhealthy lifestyle and/or family history of colorectal cancer were more likely to develop advanced stage colorectal cancer and to have a poor disease prognosis compared to patients with healthy lifestyle and/or sporadic colorectal cancer. These data suggest that a mass screening program should be implemented in northeastern Brazil in order to better prevent and treat colorectal cancer. 2018-06-16T11:31:58Z 2018-06-16T11:31:58Z 2013 article ARAÚJO, Aurigena Antunes de et al. Lifestyle and family history influence cancer prognosis in Brazilian individuals. Pathology, Research and Practice, v. 209, p. 753-757, 2013. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0344033813002112>. Acesso em: 14 mar. 2018. 1618-0631 https://repositorio.ufrn.br/jspui/handle/123456789/25414 https://doi.org/10.1016/j.prp.2013.08.007 por Acesso Aberto application/pdf Elsevier |
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Colorectal cancer Brazil Survival Neoplasm by site Public health |
| spellingShingle |
Colorectal cancer Brazil Survival Neoplasm by site Public health Araújo, Aurigena Antunes de Araújo Jr, Raimundo F. Lira, George A. Guedes, Hugo G. Cardoso, Marília A. Cavalcante, Francisco J. Araújo, Ana Lucia M. Ramos, Carlos César O. Lifestyle and family history influence cancer prognosis in Brazilian individuals |
| description |
The aim of this research was to study prognostic parameters of CRC by analyzing clinical and pathological
variables associated with cancer patients at a northeastern Brazilian Hospital.
This was a retrospective study evaluating CRC-diagnosed patients across a 10-year period (1995–2005)
at Dr. Luiz Antônio Hospital in Natal, RN, Brazil. Data were collected from patients’ medical files.
A total of 358 patients were included over the 10-year period. The average age at diagnosis was 58.8
years (S.D. = 15.26), 48.3% of the patients were males and 51.7% were females. Alcohol consumption
significantly increased the chance of dying (p < 0.023) from colorectal cancer; this increased risk of death
was approximately 71%, compared to 52.2% of the non-alcoholics. In addition, tobacco increased the
chance of developing high TNM stage tumors (level III, IV; p < 0.001). Another risk factor for increased
mortality was a family history for colorectal cancer (p < 0.002).
Our analysis found that patients with an unhealthy lifestyle and/or family history of colorectal cancer
were more likely to develop advanced stage colorectal cancer and to have a poor disease prognosis
compared to patients with healthy lifestyle and/or sporadic colorectal cancer. These data suggest that a
mass screening program should be implemented in northeastern Brazil in order to better prevent and
treat colorectal cancer. |
| format |
article |
| author |
Araújo, Aurigena Antunes de Araújo Jr, Raimundo F. Lira, George A. Guedes, Hugo G. Cardoso, Marília A. Cavalcante, Francisco J. Araújo, Ana Lucia M. Ramos, Carlos César O. |
| author_facet |
Araújo, Aurigena Antunes de Araújo Jr, Raimundo F. Lira, George A. Guedes, Hugo G. Cardoso, Marília A. Cavalcante, Francisco J. Araújo, Ana Lucia M. Ramos, Carlos César O. |
| author_sort |
Araújo, Aurigena Antunes de |
| title |
Lifestyle and family history influence cancer prognosis in Brazilian individuals |
| title_short |
Lifestyle and family history influence cancer prognosis in Brazilian individuals |
| title_full |
Lifestyle and family history influence cancer prognosis in Brazilian individuals |
| title_fullStr |
Lifestyle and family history influence cancer prognosis in Brazilian individuals |
| title_full_unstemmed |
Lifestyle and family history influence cancer prognosis in Brazilian individuals |
| title_sort |
lifestyle and family history influence cancer prognosis in brazilian individuals |
| publisher |
Elsevier |
| publishDate |
2018 |
| url |
https://repositorio.ufrn.br/jspui/handle/123456789/25414 https://doi.org/10.1016/j.prp.2013.08.007 |
| work_keys_str_mv |
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