Neurofunctional changes after a single mirror therapy intervention in chronic ischemic stroke

Background: Mirror therapy (MT) is becoming an alternative rehabilitation strategy for various conditions, including stroke. Although recent studies suggest the positive benefit of MT in chronic stroke motor recovery, little is known about its neural mechanisms. Purpose: To identify functional br...

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Principais autores: Novaes, Morgana M., Palhano-Fontes, Fernanda, Peres, Andre, Mazzetto-Betti, Kelley, Pelicioni, Maristela, Andrade, Kátia C., Santos, Antonio Carlos dos, Pontes-Neto, Octavio, Araújo, Dráulio Barros de
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Idioma:eng
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Mirror therapy
ischemic stroke
stroke rehabilitation
transcranial magnetic stimulation
functional magnetic resonance imaging
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/25140
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spelling ri-123456789-251402021-07-08T18:30:06Z Neurofunctional changes after a single mirror therapy intervention in chronic ischemic stroke Novaes, Morgana M. Palhano-Fontes, Fernanda Peres, Andre Mazzetto-Betti, Kelley Pelicioni, Maristela Andrade, Kátia C. Santos, Antonio Carlos dos Pontes-Neto, Octavio Araújo, Dráulio Barros de Mirror therapy ischemic stroke stroke rehabilitation transcranial magnetic stimulation functional magnetic resonance imaging Background: Mirror therapy (MT) is becoming an alternative rehabilitation strategy for various conditions, including stroke. Although recent studies suggest the positive benefit of MT in chronic stroke motor recovery, little is known about its neural mechanisms. Purpose: To identify functional brain changes induced by a single MT intervention in ischemic stroke survivors, assessed by both transcranial magnetic stimulation (TMS) and functional magnetic resonance imaging (fMRI). Materials and methods: TMS and fMRI were used to investigate 15 stroke survivors immediately before and after a single 30-min MT session. Results: We found statistically significant increase in post-MT motor evoked potential (MEP) amplitude (increased excitability) from the affected primary motor cortex (M1), when compared to pre-MT MEP. Post-MT fMRI maps were associated with a more organized and constrained pattern, with a more focal M1 activity within the affected hemisphere after MT, limited to the cortical area of hand representation. Furthermore, we find a change in the balance of M1 activity toward the affected hemisphere. In addition, significant correlation was found between decreased fMRI β-values and increased MEP amplitude post-MT, in the affected hemisphere. Conclusion: Our study suggests that a single MT intervention in stroke survivors is related to increased MEP of the affected limb, and a more constrained activity of the affected M1, as if activity had become more constrained and limited to the affected hemisphere. 2018-05-09T13:27:03Z 2018-05-09T13:27:03Z 2018-03-20 article NOVAES, M. M. et al. Neurofunctional changes after a single mirror therapy intervention in chronic ischemic stroke. Int J Neurosci., v. 20, p. 1-9, mar./2018. DOI:10.1080/00207454.2018.1447571 https://repositorio.ufrn.br/jspui/handle/123456789/25140 10.1080/00207454.2018.1447571 eng Acesso Aberto application/pdf
institution Repositório Institucional
collection RI - UFRN
language eng
topic Mirror therapy
ischemic stroke
stroke rehabilitation
transcranial magnetic stimulation
functional magnetic resonance imaging
spellingShingle Mirror therapy
ischemic stroke
stroke rehabilitation
transcranial magnetic stimulation
functional magnetic resonance imaging
Novaes, Morgana M.
Palhano-Fontes, Fernanda
Peres, Andre
Mazzetto-Betti, Kelley
Pelicioni, Maristela
Andrade, Kátia C.
Santos, Antonio Carlos dos
Pontes-Neto, Octavio
Araújo, Dráulio Barros de
Neurofunctional changes after a single mirror therapy intervention in chronic ischemic stroke
description Background: Mirror therapy (MT) is becoming an alternative rehabilitation strategy for various conditions, including stroke. Although recent studies suggest the positive benefit of MT in chronic stroke motor recovery, little is known about its neural mechanisms. Purpose: To identify functional brain changes induced by a single MT intervention in ischemic stroke survivors, assessed by both transcranial magnetic stimulation (TMS) and functional magnetic resonance imaging (fMRI). Materials and methods: TMS and fMRI were used to investigate 15 stroke survivors immediately before and after a single 30-min MT session. Results: We found statistically significant increase in post-MT motor evoked potential (MEP) amplitude (increased excitability) from the affected primary motor cortex (M1), when compared to pre-MT MEP. Post-MT fMRI maps were associated with a more organized and constrained pattern, with a more focal M1 activity within the affected hemisphere after MT, limited to the cortical area of hand representation. Furthermore, we find a change in the balance of M1 activity toward the affected hemisphere. In addition, significant correlation was found between decreased fMRI β-values and increased MEP amplitude post-MT, in the affected hemisphere. Conclusion: Our study suggests that a single MT intervention in stroke survivors is related to increased MEP of the affected limb, and a more constrained activity of the affected M1, as if activity had become more constrained and limited to the affected hemisphere.
format article
author Novaes, Morgana M.
Palhano-Fontes, Fernanda
Peres, Andre
Mazzetto-Betti, Kelley
Pelicioni, Maristela
Andrade, Kátia C.
Santos, Antonio Carlos dos
Pontes-Neto, Octavio
Araújo, Dráulio Barros de
author_facet Novaes, Morgana M.
Palhano-Fontes, Fernanda
Peres, Andre
Mazzetto-Betti, Kelley
Pelicioni, Maristela
Andrade, Kátia C.
Santos, Antonio Carlos dos
Pontes-Neto, Octavio
Araújo, Dráulio Barros de
author_sort Novaes, Morgana M.
title Neurofunctional changes after a single mirror therapy intervention in chronic ischemic stroke
title_short Neurofunctional changes after a single mirror therapy intervention in chronic ischemic stroke
title_full Neurofunctional changes after a single mirror therapy intervention in chronic ischemic stroke
title_fullStr Neurofunctional changes after a single mirror therapy intervention in chronic ischemic stroke
title_full_unstemmed Neurofunctional changes after a single mirror therapy intervention in chronic ischemic stroke
title_sort neurofunctional changes after a single mirror therapy intervention in chronic ischemic stroke
publishDate 2018
url https://repositorio.ufrn.br/jspui/handle/123456789/25140
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