Subtle Alterations in Spatial Memory Induced by Amyloid Peptides Infusion in Rats
The cause of Alzheimer’s disease (AD) remains uncertain. The accumulation of amyloid peptides (Ab) is the main pathophysiological hallmark of the disease. Spatial deficit is an important initial sign of AD, while other types of memory impairments that appear in later stages. The Barnes maze allow...
Na minha lista:
Principais autores: | , , , , , , , , |
---|---|
Formato: | article |
Idioma: | eng |
Publicado em: |
|
Assuntos: | |
Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/24684 |
Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|
Resumo: | The cause of Alzheimer’s disease (AD) remains uncertain. The accumulation of amyloid
peptides (Ab) is the main pathophysiological hallmark of the disease. Spatial deficit
is an important initial sign of AD, while other types of memory impairments that
appear in later stages. The Barnes maze allows the detection of subtle alterations in
spatial search by the analysis of use of different strategies. Previous findings showed
a general performance deficit in this task following long-term (35 days) infusion of
Ab, which corresponds to the moderate or severe impairments of the disease. In the
present study, we evaluated the effects of a low-dose 15-day long treatment with Ab
peptides on spatial and non-spatial strategies of rats tested in the Barnes maze. Ab
peptides (0.5 mL/site/day; 30 pmoL solution of Ab1–40:Ab1–42 10:1) or saline were
bilaterally infused into the CA1 (on the first treatment day) and intraventricularly (on the
following 15 days) in 6-month-old Wistar male rats. Ab infusion induced a deficit in the
performance (increased latency and distance traveled to reach the target compared
to saline group). In addition, a significant association between treatment and search
strategy in the retrieval trial was found: Ab group preferred the non-spatial search
strategy, while saline group preferred the spatial search. In conclusion, the protocol
of Ab infusion used here induced a subtle cognitive deficit that was specific to spatial
aspects. Indeed, animals under Ab treatment still showed retrieval, but using non-spatial
strategies. We suggest that this approach is potentially useful to the study of the initial
memory deficits in early AD. |
---|