A Dose for the wiser is enough: the alcohol benefits for associative learning in zebrafish

This study aimed to test seeking behavior caused by alcohol and the drug effects on learning in the zebrafish, Danio rerio. Three treatments were conducted: acute, chronic and withdrawal, using 0.10%, 0.25%, and 1.00% alcohol and control (0.00%) (vol/vol.%). For the drug seeking behavior, we used...

ver descrição completa

Na minha lista:

Detalhes bibliográficos
Principais autores:	Chacon, Diana, Luchiari, Ana Carolina
Formato:	article
Idioma:	eng
Publicado em:	Elsevier
Assuntos:	Conditioned learning Danio rerio Drug seeking behavior Ethanol
Endereço do item:	https://repositorio.ufrn.br/jspui/handle/123456789/24649
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!

id	ri-123456789-24649
record_format	dspace
spelling	ri-123456789-246492021-11-08T21:17:07Z A Dose for the wiser is enough: the alcohol benefits for associative learning in zebrafish Chacon, Diana Luchiari, Ana Carolina Conditioned learning Danio rerio Drug seeking behavior Ethanol This study aimed to test seeking behavior caused by alcohol and the drug effects on learning in the zebrafish, Danio rerio. Three treatments were conducted: acute, chronic and withdrawal, using 0.10%, 0.25%, and 1.00% alcohol and control (0.00%) (vol/vol.%). For the drug seeking behavior, we used a place preference paradigm (shuttle box tank) before and after alcohol exposure in acute (single exposure) and chronic (7 days) treatments. We observed a change in the basal preference due to the association with alcohol only for 0.25% and 1.00% doses in both acute and chronic offering, indicating an alcohol-seeking behavior after the drug exposure. For the learning task, two treatmentswere tested: chronic alcohol exposure (26 days including the learning period) and alcoholwithdrawal (15 days of alcohol exposure before the learning period). During the learning period, fish received light stimulus followed by food in a pre-defined area of the tank for 8 consecutive days. The low dose group (0.10%) learned the task by the 3rd day both in chronic and withdrawal treatments. The higher doses (0.25% and 1.00%) caused a learning impairment in the chronic treatment group, while fish from the alcohol withdrawal treatment displayed learning on the final testing day. Therefore, we suggest that high alcohol doses impair learning and cause drug seeking behavior, even after drug exposure cessation, while lowdoses positively affect learning and do not cause seeking behavior. Given our results we propose that the zebrafish is a promising model for identifying active compounds, antibodies or genes which modulate the alcohol dual effects: learning improvement and reinforcing behavior 2018-01-24T20:07:09Z 2018-01-24T20:07:09Z 2014 article CHACON, Diana; LUCHIARI, Ana Carolina. A dose for the wiser is enough: the alcohol benefits for associative learning in zebrafish. Progress in Neuro-Psychopharmacology & Biological Psychiatry, v. 53, p. 109-115, 2014. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0278584614000621?via%3Dihub>. Acesso em: 18 out. 2017. 0278-5846 https://repositorio.ufrn.br/jspui/handle/123456789/24649 10.1016/j.pnpbp.2014.03.009 eng Acesso Aberto application/pdf Elsevier
institution	Repositório Institucional
collection	RI - UFRN
language	eng
topic	Conditioned learning Danio rerio Drug seeking behavior Ethanol
spellingShingle	Conditioned learning Danio rerio Drug seeking behavior Ethanol Chacon, Diana Luchiari, Ana Carolina A Dose for the wiser is enough: the alcohol benefits for associative learning in zebrafish
description	This study aimed to test seeking behavior caused by alcohol and the drug effects on learning in the zebrafish, Danio rerio. Three treatments were conducted: acute, chronic and withdrawal, using 0.10%, 0.25%, and 1.00% alcohol and control (0.00%) (vol/vol.%). For the drug seeking behavior, we used a place preference paradigm (shuttle box tank) before and after alcohol exposure in acute (single exposure) and chronic (7 days) treatments. We observed a change in the basal preference due to the association with alcohol only for 0.25% and 1.00% doses in both acute and chronic offering, indicating an alcohol-seeking behavior after the drug exposure. For the learning task, two treatmentswere tested: chronic alcohol exposure (26 days including the learning period) and alcoholwithdrawal (15 days of alcohol exposure before the learning period). During the learning period, fish received light stimulus followed by food in a pre-defined area of the tank for 8 consecutive days. The low dose group (0.10%) learned the task by the 3rd day both in chronic and withdrawal treatments. The higher doses (0.25% and 1.00%) caused a learning impairment in the chronic treatment group, while fish from the alcohol withdrawal treatment displayed learning on the final testing day. Therefore, we suggest that high alcohol doses impair learning and cause drug seeking behavior, even after drug exposure cessation, while lowdoses positively affect learning and do not cause seeking behavior. Given our results we propose that the zebrafish is a promising model for identifying active compounds, antibodies or genes which modulate the alcohol dual effects: learning improvement and reinforcing behavior
format	article
author	Chacon, Diana Luchiari, Ana Carolina
author_facet	Chacon, Diana Luchiari, Ana Carolina
author_sort	Chacon, Diana
title	A Dose for the wiser is enough: the alcohol benefits for associative learning in zebrafish
title_short	A Dose for the wiser is enough: the alcohol benefits for associative learning in zebrafish
title_full	A Dose for the wiser is enough: the alcohol benefits for associative learning in zebrafish
title_fullStr	A Dose for the wiser is enough: the alcohol benefits for associative learning in zebrafish
title_full_unstemmed	A Dose for the wiser is enough: the alcohol benefits for associative learning in zebrafish
title_sort	dose for the wiser is enough: the alcohol benefits for associative learning in zebrafish
publisher	Elsevier
publishDate	2018
url	https://repositorio.ufrn.br/jspui/handle/123456789/24649
work_keys_str_mv	AT chacondiana adoseforthewiserisenoughthealcoholbenefitsforassociativelearninginzebrafish AT luchiarianacarolina adoseforthewiserisenoughthealcoholbenefitsforassociativelearninginzebrafish AT chacondiana doseforthewiserisenoughthealcoholbenefitsforassociativelearninginzebrafish AT luchiarianacarolina doseforthewiserisenoughthealcoholbenefitsforassociativelearninginzebrafish
_version_	1773967041940684800

A Dose for the wiser is enough: the alcohol benefits for associative learning in zebrafish

Registros relacionados