Specific phospholipids regulate the acquisition of neuronal and astroglial identities in post-mitotic cells

Hitherto, the known mechanisms underpinning cell-fate specification act on neural progenitors, affecting their commitment to generate neuron or glial cells. Here, we show that particular phospholipids supplemented in the culture media modify the commitment of post-mitotic neural cells in vitro. Phos...

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Principais autores:	Montaner, Aneley, Santana, Themis Taynah da Silva, Schroeder, Timm, Einiker-Lamas, Marcelo, Girardini, Javier, Costa, Marcos Romualdo, Banchio, Claudia
Formato:	article
Idioma:	eng
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Assuntos:	glial cells post-mitotic cells phospholipids cell plasticity cell biology
Endereço do item:	https://repositorio.ufrn.br/jspui/handle/123456789/24537
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spelling	ri-123456789-245372019-01-30T03:48:02Z Specific phospholipids regulate the acquisition of neuronal and astroglial identities in post-mitotic cells Montaner, Aneley Santana, Themis Taynah da Silva Schroeder, Timm Einiker-Lamas, Marcelo Girardini, Javier Costa, Marcos Romualdo Banchio, Claudia glial cells post-mitotic cells phospholipids cell plasticity cell biology Hitherto, the known mechanisms underpinning cell-fate specification act on neural progenitors, affecting their commitment to generate neuron or glial cells. Here, we show that particular phospholipids supplemented in the culture media modify the commitment of post-mitotic neural cells in vitro. Phosphatidylcholine (PtdCho)-enriched media enhances neuronal differentiation at the expense of astroglial and unspecified cells. Conversely, phosphatidylethanolamine (PtdEtn) enhances astroglial differentiation and accelerates astrocyte maturation. The ability of phospholipids to modify the fate of post-mitotic cells depends on its presence during a narrow time-window during cell differentiation and it is mediated by the selective activation of particular signaling pathways. While PtdCho-mediated effect on neuronal differentiation depends on cAMP-dependent kinase (PKA)/calcium responsive element binding protein (CREB), PtdEtn stimulates astrogliogenesis through the activation of the MEK/ERK signaling pathway. Collectively, our results provide an additional degree of plasticity in neural cell specification and further support the notion that cell differentiation is a reversible phenomenon. They also contribute to our understanding of neuronal and glial lineage specification in the central nervous system, opening up new avenues to retrieve neurogenic capacity in the brain. 2018-01-12T11:48:21Z 2018-01-12T11:48:21Z 2018-01-11 article https://repositorio.ufrn.br/jspui/handle/123456789/24537 10.1038/s41598-017-18700-4 eng Acesso Aberto application/pdf
institution	Repositório Institucional
collection	RI - UFRN
language	eng
topic	glial cells post-mitotic cells phospholipids cell plasticity cell biology
spellingShingle	glial cells post-mitotic cells phospholipids cell plasticity cell biology Montaner, Aneley Santana, Themis Taynah da Silva Schroeder, Timm Einiker-Lamas, Marcelo Girardini, Javier Costa, Marcos Romualdo Banchio, Claudia Specific phospholipids regulate the acquisition of neuronal and astroglial identities in post-mitotic cells
description	Hitherto, the known mechanisms underpinning cell-fate specification act on neural progenitors, affecting their commitment to generate neuron or glial cells. Here, we show that particular phospholipids supplemented in the culture media modify the commitment of post-mitotic neural cells in vitro. Phosphatidylcholine (PtdCho)-enriched media enhances neuronal differentiation at the expense of astroglial and unspecified cells. Conversely, phosphatidylethanolamine (PtdEtn) enhances astroglial differentiation and accelerates astrocyte maturation. The ability of phospholipids to modify the fate of post-mitotic cells depends on its presence during a narrow time-window during cell differentiation and it is mediated by the selective activation of particular signaling pathways. While PtdCho-mediated effect on neuronal differentiation depends on cAMP-dependent kinase (PKA)/calcium responsive element binding protein (CREB), PtdEtn stimulates astrogliogenesis through the activation of the MEK/ERK signaling pathway. Collectively, our results provide an additional degree of plasticity in neural cell specification and further support the notion that cell differentiation is a reversible phenomenon. They also contribute to our understanding of neuronal and glial lineage specification in the central nervous system, opening up new avenues to retrieve neurogenic capacity in the brain.
format	article
author	Montaner, Aneley Santana, Themis Taynah da Silva Schroeder, Timm Einiker-Lamas, Marcelo Girardini, Javier Costa, Marcos Romualdo Banchio, Claudia
author_facet	Montaner, Aneley Santana, Themis Taynah da Silva Schroeder, Timm Einiker-Lamas, Marcelo Girardini, Javier Costa, Marcos Romualdo Banchio, Claudia
author_sort	Montaner, Aneley
title	Specific phospholipids regulate the acquisition of neuronal and astroglial identities in post-mitotic cells
title_short	Specific phospholipids regulate the acquisition of neuronal and astroglial identities in post-mitotic cells
title_full	Specific phospholipids regulate the acquisition of neuronal and astroglial identities in post-mitotic cells
title_fullStr	Specific phospholipids regulate the acquisition of neuronal and astroglial identities in post-mitotic cells
title_full_unstemmed	Specific phospholipids regulate the acquisition of neuronal and astroglial identities in post-mitotic cells
title_sort	specific phospholipids regulate the acquisition of neuronal and astroglial identities in post-mitotic cells
publishDate	2018
url	https://repositorio.ufrn.br/jspui/handle/123456789/24537
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Specific phospholipids regulate the acquisition of neuronal and astroglial identities in post-mitotic cells

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