Behavioral changes over time following ayahuasca exposure in zebrafish
The combined infusion of Banisteriopsis caapi stem and Psychotria viridis leaves, known as ayahuasca, has been used for centuries by indigenous tribes. The infusion is rich in N, N-dimethyltryptamine (DMT) and monoamine oxidase inhibitors, with properties similar to those of serotonin. Despite su...
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| Principais autores: | , , , , , , , |
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| Formato: | article |
| Idioma: | eng |
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| Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/24536 |
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| Resumo: | The combined infusion of Banisteriopsis caapi stem and Psychotria viridis leaves, known
as ayahuasca, has been used for centuries by indigenous tribes. The infusion is rich
in N, N-dimethyltryptamine (DMT) and monoamine oxidase inhibitors, with properties
similar to those of serotonin. Despite substantial progress in the development of new
drugs to treat anxiety and depression, current treatments have several limitations.
Alternative drugs, such as ayahuasca, may shed light on these disorders. Here, we
present time-course behavioral changes induced by ayahuasca in zebrafish, as first
step toward establishing an ideal concentration for pre-clinical evaluations. We exposed
adult zebrafish to five concentrations of the ayahuasca infusion: 0 (control), 0.1, 0.5, 1,
and 3 ml/L (n D 14 each group), and behavior was recorded for 60 min. We evaluated
swimming speed, distance traveled, freezing and bottom dwelling every min for 60 min.
Swimming speed and distance traveled decreased with an increase in ayahuasca
concentration while freezing increased with 1 and 3 ml/L. Bottom dwelling increased
with 1 and 3 ml/L, but declined with 0.1 ml/L. Our data suggest that small amounts
of ayahuasca do not affect locomotion and reduce anxiety-like behavior in zebrafish,
while increased doses of the drug lead to crescent anxiogenic effects. We conclude
that the temporal analysis of zebrafish behavior is a sensitive method for the study of
ayahuasca-induced functional changes in the vertebrate brain |
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