Good night, sleep tight: the effects of sleep deprivation on spatial associative learning in zebrafish

Learning and memory are vital to an animal's survival, and numerous factors can disrupt cognitive performance. Sleep is an evolutionarily conserved physiological process known to be important for the consolidation of learning and memory. The zebrafish has emerged as a powerful model organism...

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Principais autores: Silva, Jaquelinne Pinheiro da, Tran, Steven, Silva, Priscila Fernandes, Luchiari, Ana Carolina
Formato: article
Idioma:eng
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Assuntos:
Learning
Memory
Associative learning task
Sleep
Social reward
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/24534
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spelling ri-123456789-245342021-11-08T20:12:31Z Good night, sleep tight: the effects of sleep deprivation on spatial associative learning in zebrafish Silva, Jaquelinne Pinheiro da Tran, Steven Silva, Priscila Fernandes Luchiari, Ana Carolina Learning Memory Associative learning task Sleep Social reward Learning and memory are vital to an animal's survival, and numerous factors can disrupt cognitive performance. Sleep is an evolutionarily conserved physiological process known to be important for the consolidation of learning and memory. The zebrafish has emerged as a powerful model organism sharing organizational and functional characteristics with other vertebrates, providing great translational relevance. In our study, we used a simple spatial associative learning task to quantify the effects of sleep deprivation (partial vs. total) on learning performance in zebrafish, using an animated conspecific shoal image as a reward. Control animals maintained on a regular light:dark cycle were able to acquire the association between the unconditioned and conditioned stimulus, reinforcing zebrafish as a valid and reliable model for appetitive conditioning tasks. Notably, sleep deprivation did not alter the perception of and response to the conspecific image. In contrast, although partial sleep deprivation did not impair cognitive performance, total sleep deprivation significantly impaired performance on the associative learning task. Our results suggest that sleep is important for learning and memory, and that the effects of sleep deprivation on these processes can be investigated in zebrafish 2018-01-08T14:14:54Z 2018-01-08T14:14:54Z 2017-06-23 article SILVA, Jaquelinne Pinheiro da; et al. Good night, sleep tight: the effects of sleep deprivation on spatial associative learning in zebrafish. Pharmacology Biochemistry and Behavior, v. 1, p. 11-19, jun. 2017. Disponível em:<http://www.sciencedirect.com/science/article/pii/S0091305716303148?via%3Dihub>. Acesso em: 16 out. 2017. 0091-3057 https://repositorio.ufrn.br/jspui/handle/123456789/24534 eng Acesso Aberto application/pdf
institution Repositório Institucional
collection RI - UFRN
language eng
topic Learning
Memory
Associative learning task
Sleep
Social reward
spellingShingle Learning
Memory
Associative learning task
Sleep
Social reward
Silva, Jaquelinne Pinheiro da
Tran, Steven
Silva, Priscila Fernandes
Luchiari, Ana Carolina
Good night, sleep tight: the effects of sleep deprivation on spatial associative learning in zebrafish
description Learning and memory are vital to an animal's survival, and numerous factors can disrupt cognitive performance. Sleep is an evolutionarily conserved physiological process known to be important for the consolidation of learning and memory. The zebrafish has emerged as a powerful model organism sharing organizational and functional characteristics with other vertebrates, providing great translational relevance. In our study, we used a simple spatial associative learning task to quantify the effects of sleep deprivation (partial vs. total) on learning performance in zebrafish, using an animated conspecific shoal image as a reward. Control animals maintained on a regular light:dark cycle were able to acquire the association between the unconditioned and conditioned stimulus, reinforcing zebrafish as a valid and reliable model for appetitive conditioning tasks. Notably, sleep deprivation did not alter the perception of and response to the conspecific image. In contrast, although partial sleep deprivation did not impair cognitive performance, total sleep deprivation significantly impaired performance on the associative learning task. Our results suggest that sleep is important for learning and memory, and that the effects of sleep deprivation on these processes can be investigated in zebrafish
format article
author Silva, Jaquelinne Pinheiro da
Tran, Steven
Silva, Priscila Fernandes
Luchiari, Ana Carolina
author_facet Silva, Jaquelinne Pinheiro da
Tran, Steven
Silva, Priscila Fernandes
Luchiari, Ana Carolina
author_sort Silva, Jaquelinne Pinheiro da
title Good night, sleep tight: the effects of sleep deprivation on spatial associative learning in zebrafish
title_short Good night, sleep tight: the effects of sleep deprivation on spatial associative learning in zebrafish
title_full Good night, sleep tight: the effects of sleep deprivation on spatial associative learning in zebrafish
title_fullStr Good night, sleep tight: the effects of sleep deprivation on spatial associative learning in zebrafish
title_full_unstemmed Good night, sleep tight: the effects of sleep deprivation on spatial associative learning in zebrafish
title_sort good night, sleep tight: the effects of sleep deprivation on spatial associative learning in zebrafish
publishDate 2018
url https://repositorio.ufrn.br/jspui/handle/123456789/24534
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AT transteven goodnightsleeptighttheeffectsofsleepdeprivationonspatialassociativelearninginzebrafish
AT silvapriscilafernandes goodnightsleeptighttheeffectsofsleepdeprivationonspatialassociativelearninginzebrafish
AT luchiarianacarolina goodnightsleeptighttheeffectsofsleepdeprivationonspatialassociativelearninginzebrafish
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