Sleep deprivation effects on object discrimination task in zebrafish (Danio rerio)

The zebrafish is an ideal vertebrate model for neurobehavioral studies with translational relevance to humans. Many aspects of sleep have been studied, but we still do not understand how and why sleep deprivation alters behavioral and physiological processes. A number of hypotheses suggest its...

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Principais autores: Silva, Jaquelinne Pinheiro da, Silva, Priscila Fernandes, Nogueira, Marcelo Borges, Luchiari, Ana Carolina
Formato: article
Idioma:eng
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Assuntos:
Sleep
Fish
Memory
Discrimination
Bayesian analysis
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/24532
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spelling ri-123456789-245322021-11-08T20:08:30Z Sleep deprivation effects on object discrimination task in zebrafish (Danio rerio) Silva, Jaquelinne Pinheiro da Silva, Priscila Fernandes Nogueira, Marcelo Borges Luchiari, Ana Carolina Sleep Fish Memory Discrimination Bayesian analysis The zebrafish is an ideal vertebrate model for neurobehavioral studies with translational relevance to humans. Many aspects of sleep have been studied, but we still do not understand how and why sleep deprivation alters behavioral and physiological processes. A number of hypotheses suggest its role in memory consolidation. In this respect, the aim of this study was to analyze the effects of sleep deprivation on memory in zebrafish (Danio rerio), using an object discrimination paradigm. Four treatments were tested: control, partial sleep deprivation, total sleep deprivation by light pulses, and total sleep deprivation by extended light. The control group explored the new object more than the known object, indicating clear discrimination. The partially sleep-deprived group explored the new object more than the other object in the discrimination phase, suggesting a certain degree of discriminative performance. By contrast, both total sleep deprivation groups equally explored all objects, regardless of their novelty. It seems that only one night of sleep deprivation is enough to affect discriminative response in zebrafish, indicating its negative impact on cognitive processes. We suggest that this study could be a useful screening tool for cognitive dysfunction and a better understanding of the effect of sleep-wake cycles on cognition 2018-01-08T13:26:19Z 2018-01-08T13:26:19Z 2016-09-19 article SILVA, Jaquelinne Pinheiro da; et al. Sleep deprivation effects on object discrimination task in zebrafish (Danio rerio). Animal Cognition, v. 20, p. 159-169, set. 2016. Disponível em:<https://link.springer.com/article/10.1007/s10071-016-1034-x>. Acesso em: 16 out. 2017. 1435-9448 https://repositorio.ufrn.br/jspui/handle/123456789/24532 eng Acesso Aberto application/pdf
institution Repositório Institucional
collection RI - UFRN
language eng
topic Sleep
Fish
Memory
Discrimination
Bayesian analysis
spellingShingle Sleep
Fish
Memory
Discrimination
Bayesian analysis
Silva, Jaquelinne Pinheiro da
Silva, Priscila Fernandes
Nogueira, Marcelo Borges
Luchiari, Ana Carolina
Sleep deprivation effects on object discrimination task in zebrafish (Danio rerio)
description The zebrafish is an ideal vertebrate model for neurobehavioral studies with translational relevance to humans. Many aspects of sleep have been studied, but we still do not understand how and why sleep deprivation alters behavioral and physiological processes. A number of hypotheses suggest its role in memory consolidation. In this respect, the aim of this study was to analyze the effects of sleep deprivation on memory in zebrafish (Danio rerio), using an object discrimination paradigm. Four treatments were tested: control, partial sleep deprivation, total sleep deprivation by light pulses, and total sleep deprivation by extended light. The control group explored the new object more than the known object, indicating clear discrimination. The partially sleep-deprived group explored the new object more than the other object in the discrimination phase, suggesting a certain degree of discriminative performance. By contrast, both total sleep deprivation groups equally explored all objects, regardless of their novelty. It seems that only one night of sleep deprivation is enough to affect discriminative response in zebrafish, indicating its negative impact on cognitive processes. We suggest that this study could be a useful screening tool for cognitive dysfunction and a better understanding of the effect of sleep-wake cycles on cognition
format article
author Silva, Jaquelinne Pinheiro da
Silva, Priscila Fernandes
Nogueira, Marcelo Borges
Luchiari, Ana Carolina
author_facet Silva, Jaquelinne Pinheiro da
Silva, Priscila Fernandes
Nogueira, Marcelo Borges
Luchiari, Ana Carolina
author_sort Silva, Jaquelinne Pinheiro da
title Sleep deprivation effects on object discrimination task in zebrafish (Danio rerio)
title_short Sleep deprivation effects on object discrimination task in zebrafish (Danio rerio)
title_full Sleep deprivation effects on object discrimination task in zebrafish (Danio rerio)
title_fullStr Sleep deprivation effects on object discrimination task in zebrafish (Danio rerio)
title_full_unstemmed Sleep deprivation effects on object discrimination task in zebrafish (Danio rerio)
title_sort sleep deprivation effects on object discrimination task in zebrafish (danio rerio)
publishDate 2018
url https://repositorio.ufrn.br/jspui/handle/123456789/24532
work_keys_str_mv AT silvajaquelinnepinheiroda sleepdeprivationeffectsonobjectdiscriminationtaskinzebrafishdaniorerio
AT silvapriscilafernandes sleepdeprivationeffectsonobjectdiscriminationtaskinzebrafishdaniorerio
AT nogueiramarceloborges sleepdeprivationeffectsonobjectdiscriminationtaskinzebrafishdaniorerio
AT luchiarianacarolina sleepdeprivationeffectsonobjectdiscriminationtaskinzebrafishdaniorerio
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