Investigação de aspectos neuropsicológicos e acadêmicos em crianças e adolescentes sobreviventes de leucemia linfoide aguda - LLA
Acute lymphoblastic leukemia (ALL) is the most common type of cancer among children and adolescents. The sophistication of the diagnostic and therapeutic processes has promoted an increase in survival and reduction of relapse of the disease. The inclusion of prophylactic CNS therapy, performed th...
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ri-123456789-24491 |
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dspace |
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Repositório Institucional |
| collection |
RI - UFRN |
| language |
por |
| topic |
Neuropsicologia Neurodesenvolvimento Oncologia pediátrica Aprendizagem Quimioterapia CNPQ::CIENCIAS HUMANAS::PSICOLOGIA |
| spellingShingle |
Neuropsicologia Neurodesenvolvimento Oncologia pediátrica Aprendizagem Quimioterapia CNPQ::CIENCIAS HUMANAS::PSICOLOGIA Gomes, Ediana Rosselly de Oliveira Investigação de aspectos neuropsicológicos e acadêmicos em crianças e adolescentes sobreviventes de leucemia linfoide aguda - LLA |
| description |
Acute lymphoblastic leukemia (ALL) is the most common type of cancer among children
and adolescents. The sophistication of the diagnostic and therapeutic processes has
promoted an increase in survival and reduction of relapse of the disease. The inclusion of
prophylactic CNS therapy, performed through chemotherapy and/or radiotherapy, has
been identified as essential for therapeutic success, but it seems to be related to the
emergence of late neuropsychological effects in about 30% of survivors. Studies suggest
that changes in specific cognitive domains contribute to the decline of intellectual
functioning and academic difficulties presented by this clinical population. The main
objective of the present study was to investigate the neuropsychological and academic
aspects of children and adolescents who survived ALL. The research was divided into
four studies: 1) The intellectual functioning of children and adolescents diagnosed with
ALL; 2) Attention and executive functions in pediatric survivors of ALL; 3) Translation
and adaptation of the Deasy-Spinetta Behavioral Questionnaire (DSBQ); 4) Investigation
of academic aspects in children and adolescents diagnosed with ALL. 26 children and
adolescents surviving ALL who underwent chemotherapy (clinical group), 26 healthy
children and adolescents (control group), 26 parents and 46 teachers took part in this
study. The neuropsychological evaluation protocol included the following domains:
intellectual functioning, attention, memory, executive functions, academic abilities and
behavioral aspects. The results were analyzed by descriptive and inferential statistical
tools. In study 1, the clinical group performed significantly lower than the control group.
Maternal low schooling was associated with lower performance in verbal, nonverbal and
global intellectual functioning. The younger age at diagnosis was correlated with low
verbal domain, global intellectual capacity and working memory, and the latter was also
associated with longer treatment completion time. Study 2 evidenced significantly lower performance of the clinical group in attention and executive functions, especially in the
subgroup of children diagnosed before the age of five. The results of study 3 suggested
that the DSBQ has an apparent or face validity, being a readily usable instrument. In study
4 the clinical group presented lower results in arithmetic, text comprehension and storage
processes, learning evolution and information retrieval. Specific difficulties of school
functioning were associated predominantly with the child's lower age at diagnosis. It is
hoped that the knowledge produced by this study may contribute to the development of
programs aimed at the reinsertion of the school and the elaboration of public policies for
this clinical population, as well as the accomplishment of future studies in
neuropsychology of development and learning. |
| author2 |
Pires, Izabel Augusta Hazin |
| author_facet |
Pires, Izabel Augusta Hazin Gomes, Ediana Rosselly de Oliveira |
| format |
doctoralThesis |
| author |
Gomes, Ediana Rosselly de Oliveira |
| author_sort |
Gomes, Ediana Rosselly de Oliveira |
| title |
Investigação de aspectos neuropsicológicos e acadêmicos em crianças e adolescentes sobreviventes de leucemia linfoide aguda - LLA |
| title_short |
Investigação de aspectos neuropsicológicos e acadêmicos em crianças e adolescentes sobreviventes de leucemia linfoide aguda - LLA |
| title_full |
Investigação de aspectos neuropsicológicos e acadêmicos em crianças e adolescentes sobreviventes de leucemia linfoide aguda - LLA |
| title_fullStr |
Investigação de aspectos neuropsicológicos e acadêmicos em crianças e adolescentes sobreviventes de leucemia linfoide aguda - LLA |
| title_full_unstemmed |
Investigação de aspectos neuropsicológicos e acadêmicos em crianças e adolescentes sobreviventes de leucemia linfoide aguda - LLA |
| title_sort |
investigação de aspectos neuropsicológicos e acadêmicos em crianças e adolescentes sobreviventes de leucemia linfoide aguda - lla |
| publisher |
Brasil |
| publishDate |
2017 |
| url |
https://repositorio.ufrn.br/jspui/handle/123456789/24491 |
| work_keys_str_mv |
AT gomesedianarossellydeoliveira investigacaodeaspectosneuropsicologicoseacademicosemcriancaseadolescentessobreviventesdeleucemialinfoideagudalla |
| _version_ |
1773959179482955776 |
| spelling |
ri-123456789-244912019-01-30T04:18:32Z Investigação de aspectos neuropsicológicos e acadêmicos em crianças e adolescentes sobreviventes de leucemia linfoide aguda - LLA Gomes, Ediana Rosselly de Oliveira Pires, Izabel Augusta Hazin Azoni, Cintia Alves Salgado Silva, Neuciane Gomes da Seabra, Alessandra Gotuzo Almeida, Rosa Maria Martins de Neuropsicologia Neurodesenvolvimento Oncologia pediátrica Aprendizagem Quimioterapia CNPQ::CIENCIAS HUMANAS::PSICOLOGIA Acute lymphoblastic leukemia (ALL) is the most common type of cancer among children and adolescents. The sophistication of the diagnostic and therapeutic processes has promoted an increase in survival and reduction of relapse of the disease. The inclusion of prophylactic CNS therapy, performed through chemotherapy and/or radiotherapy, has been identified as essential for therapeutic success, but it seems to be related to the emergence of late neuropsychological effects in about 30% of survivors. Studies suggest that changes in specific cognitive domains contribute to the decline of intellectual functioning and academic difficulties presented by this clinical population. The main objective of the present study was to investigate the neuropsychological and academic aspects of children and adolescents who survived ALL. The research was divided into four studies: 1) The intellectual functioning of children and adolescents diagnosed with ALL; 2) Attention and executive functions in pediatric survivors of ALL; 3) Translation and adaptation of the Deasy-Spinetta Behavioral Questionnaire (DSBQ); 4) Investigation of academic aspects in children and adolescents diagnosed with ALL. 26 children and adolescents surviving ALL who underwent chemotherapy (clinical group), 26 healthy children and adolescents (control group), 26 parents and 46 teachers took part in this study. The neuropsychological evaluation protocol included the following domains: intellectual functioning, attention, memory, executive functions, academic abilities and behavioral aspects. The results were analyzed by descriptive and inferential statistical tools. In study 1, the clinical group performed significantly lower than the control group. Maternal low schooling was associated with lower performance in verbal, nonverbal and global intellectual functioning. The younger age at diagnosis was correlated with low verbal domain, global intellectual capacity and working memory, and the latter was also associated with longer treatment completion time. Study 2 evidenced significantly lower performance of the clinical group in attention and executive functions, especially in the subgroup of children diagnosed before the age of five. The results of study 3 suggested that the DSBQ has an apparent or face validity, being a readily usable instrument. In study 4 the clinical group presented lower results in arithmetic, text comprehension and storage processes, learning evolution and information retrieval. Specific difficulties of school functioning were associated predominantly with the child's lower age at diagnosis. It is hoped that the knowledge produced by this study may contribute to the development of programs aimed at the reinsertion of the school and the elaboration of public policies for this clinical population, as well as the accomplishment of future studies in neuropsychology of development and learning. A leucemia linfoide aguda (LLA) é o tipo de câncer mais comum entre crianças e adolescentes. A sofisticação dos processos diagnósticos e terapêuticos promoveu a elevação da sobrevida e a redução das recaídas da doença. A inclusão do tratamento profilático direcionado ao SNC, realizado através de quimioterapia e/ou radioterapia, tem sido apontada como essencial para o sucesso terapêutico, todavia parece relacionar-se à emergência de efeitos neuropsicológicos tardios em cerca de 30% dos sobreviventes. Estudos sugerem que alterações sobre domínios cognitivos específicos contribuem para o declínio do funcionamento intelectual e dificuldades acadêmicas. O objetivo geral da presente pesquisa foi investigar aspectos neuropsicológicos e acadêmicos de crianças e adolescentes sobreviventes de LLA. A pesquisa foi dividida em quatro estudos: 1) Funcionamento intelectual de crianças e adolescentes diagnosticados com LLA; 2) Atenção e funções executivas em pacientes pediátricos sobreviventes de LLA; 3) Tradução e adaptação do Questionário Comportamental Deasy-Spinetta (DSBQ); 4) Investigação de aspectos acadêmicos em crianças e adolescentes diagnosticados com LLA. Participaram desse estudo 26 crianças e adolescentes sobreviventes de LLA submetidas exclusivamente à quimioterapia (grupo clínico) e 26 crianças e adolescentes saudáveis (grupo controle), além de 26 pais e 46 professores. O protocolo de avaliação neuropsicológica contemplou os seguintes domínios: funcionamento intelectual, atenção, memória, funções executivas, habilidades acadêmicas e aspectos comportamentais. Os resultados foram analisados por ferramentas estatísticas descritivas e inferenciais. No estudo 1 o grupo clínico apresentou desempenho significativamente inferior ao grupo controle. A baixa escolaridade materna foi associada a menor desempenho nos domínios verbal, não-verbal e funcionamento intelectual global. A menor idade ao diagnóstico foi correlacionada com baixos desempenhos no domínio verbal, capacidade intelectual global e memória operacional, estando esta última também associada ao maior tempo de conclusão do tratamento. O estudo 2 evidenciou desempenho significativamente inferior do grupo clínico em atenção e funções executivas, especialmente no subgrupo de crianças diagnosticadas antes dos cinco anos de idade. Os resultados do estudo 3 sugeriram que o DSBQ apresenta validade aparente ou de face, sendo um instrumento de fácil utilização. No estudo 4 o grupo clínico apresentou resultados inferiores em aritmética, compreensão de textos e nos processos de armazenamento, evolução da aprendizagem e recuperação de informações. Dificuldades específicas do funcionamento escolar associaram-se predominantemente com a menor idade da criança ao diagnóstico. Espera-se que o conhecimento produzido por esse estudo possa contribuir com o desenvolvimento de programas voltados para a reinserção escolar e a elaboração de políticas públicas para essa população clínica, bem como a realização de estudos futuros em neuropsicologia do desenvolvimento e da aprendizagem. 2017-12-12T20:27:40Z 2017-12-12T20:27:40Z 2017-09-29 doctoralThesis GOMES, Ediana Rosselly de Oliveira. Investigação de aspectos neuropsicológicos e acadêmicos em crianças e adolescentes sobreviventes de leucemia linfoide aguda - LLA. 2017. 258f. Tese (Doutorado em Psicologia) - Centro de Ciências Humanas, Letras e Artes, Universidade Federal do Rio Grande do Norte, Natal, 2017. https://repositorio.ufrn.br/jspui/handle/123456789/24491 por Acesso Aberto application/pdf Brasil UFRN PROGRAMA DE PÓS-GRADUAÇÃO EM PSICOLOGIA |