Diminuição da expressão dos receptores de melatonina MT1 e MT2 em áreas especificas do sistema nervoso central de roedores submetidos a um tratamento crônico com Reserpina
Parkinson's disease (PD) is a neurodegenerative disorder that mainly affects males with advancing age. PD is characterized by several motor symptoms such as tremors, bradykinesia, stiffness and postural changes. In addition to these, cognitive symptoms such as attention and memory deficits,...
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| Formato: | Dissertação |
| Idioma: | por |
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| Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/24445 |
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| Resumo: | Parkinson's disease (PD) is a neurodegenerative disorder that mainly affects
males with advancing age. PD is characterized by several motor symptoms
such as tremors, bradykinesia, stiffness and postural changes. In addition to
these, cognitive symptoms such as attention and memory deficits, dementia
and mood changes are also present. It is also possible to notice a marked
change in the sleep architecture of patients with PD. The hormone melatonin
synthesized mainly by the pineal gland located in the thalamus is considered
one of the hormones that induce the sleep phase of the organisms. Its action
occurs after binding to specific receptors, MT1 and MT2. In the present study,
15 male Wistar rats (10 months) were divided into two groups called Control
(CTR) and Reserpine (RES). These animals were submitted to a chronic
protocol of 20 injections of reserpine, in order to create symptoms similar to PD.
During the experimental protocol the animals were evaluated by catalepsy test.
At the end of the treatment the animals were sacrificed and submitted to an
immunohistochemical procedure to identify the MT1 and MT2 receptors in 5
areas of the central nervous system related directly to the sleep cycle and with
more evident symptoms of PD, VLPO, SN and ZSPV. Our results showed that
during the period of treatment the animals of the reserpine group presented a
considerable and progressive motor deficit that were accentuated on days
seven, eight, nine and ten of injections. Our immunohistochemical analyzes
have shown that there is a significant reduction in the expression of melatonin
receptors in the reserpine animals in all evaluated nuclei, however, new studies
are necessary to better understand the real reason for this decrease in receptor
expression and whether this decrease has a significant effect on Observed in
patients with PD. |
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