Hippocampal Theta Oscillations and Cross-Frequency Coupling during Spatial Decision-Making

Introdução The processing of spatial and mnemonic information is believed to depend on hippocampal theta oscillations (5­12 Hz). However, in rats both the power and frequency of the theta rhythm are modulated by locomotor activity, which is a major confounding factor when estimating its cognitive c...

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Principais autores: Belchior, Hindiael, Souza, Bryan, Santos, Vítor Lopes dos, Ribeiro, Sidarta Tollendal Gomes, Tort, Adriano Bretanha Lopes
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Oscillations
Local field potential
Spatial choice
Speed
Radial maze
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/24247
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spelling ri-123456789-242472021-07-09T23:10:27Z Hippocampal Theta Oscillations and Cross-Frequency Coupling during Spatial Decision-Making Belchior, Hindiael Souza, Bryan Santos, Vítor Lopes dos Ribeiro, Sidarta Tollendal Gomes Tort, Adriano Bretanha Lopes Oscillations Local field potential Spatial choice Speed Radial maze Introdução The processing of spatial and mnemonic information is believed to depend on hippocampal theta oscillations (5­12 Hz). However, in rats both the power and frequency of the theta rhythm are modulated by locomotor activity, which is a major confounding factor when estimating its cognitive correlates. Previous studies have suggested that hippocampal theta oscillations and its modulation of higher frequency rhythms support decision­making processes. Objetivos In the present study, we investigated to what extent spatial decision­making modulates hippocampal theta oscillations when controlling for variations in locomotion speed. In addition, we measured how the amplitude of low­gamma (25­50 Hz), high-gamma (60­90 Hz), and high­frequency oscillations (>100 Hz) is modulated by the phase of theta oscillations (cross­frequency coupling). Métodos We recorded local field potentials from the CA1 region of 5 male Wistar rats while animals had to choose one arm to enter for reward (goal) in a four­arm radial maze. The animals were previously trained to achieve 70% of correct choices and four sessions were used to the analyses. We then analyzed intervals of inter­trial period (DELAY), decision­making (DM), and running to reward (RUN). Trials with similar locomotion speed were used to compare theta power across intervals. We measured cross­frequency coupling within each interval and temporally triggered to the end of DM. Resultados e Conclusões We observed prominent theta oscillations and strong phase modulation of gamma amplitude during DM interval of the task, which occurred in the center of the maze before animals deliberately ran through an arm towards goal location. In speed-controlled analyses, theta power and frequency were higher during the decision period when compared to either an inter­trial delay period (also at the maze center), or to the period of running towards goal location (p<0.05, two­way ANOVA followed by Tukey's post hoc test). Moreover, theta activity was higher during decision intervals preceding correct choices than during decision intervals preceding incorrect choices (p<0.05, Student's t­test). Altogether, our data support a cognitive function for the hippocampal theta rhythm in spatial decision­making. 2017-11-13T13:49:58Z 2017-11-13T13:49:58Z 2014-09 conferenceObject https://repositorio.ufrn.br/jspui/handle/123456789/24247 eng Acesso Aberto application/pdf
institution Repositório Institucional
collection RI - UFRN
language eng
topic Oscillations
Local field potential
Spatial choice
Speed
Radial maze
spellingShingle Oscillations
Local field potential
Spatial choice
Speed
Radial maze
Belchior, Hindiael
Souza, Bryan
Santos, Vítor Lopes dos
Ribeiro, Sidarta Tollendal Gomes
Tort, Adriano Bretanha Lopes
Hippocampal Theta Oscillations and Cross-Frequency Coupling during Spatial Decision-Making
description Introdução The processing of spatial and mnemonic information is believed to depend on hippocampal theta oscillations (5­12 Hz). However, in rats both the power and frequency of the theta rhythm are modulated by locomotor activity, which is a major confounding factor when estimating its cognitive correlates. Previous studies have suggested that hippocampal theta oscillations and its modulation of higher frequency rhythms support decision­making processes. Objetivos In the present study, we investigated to what extent spatial decision­making modulates hippocampal theta oscillations when controlling for variations in locomotion speed. In addition, we measured how the amplitude of low­gamma (25­50 Hz), high-gamma (60­90 Hz), and high­frequency oscillations (>100 Hz) is modulated by the phase of theta oscillations (cross­frequency coupling). Métodos We recorded local field potentials from the CA1 region of 5 male Wistar rats while animals had to choose one arm to enter for reward (goal) in a four­arm radial maze. The animals were previously trained to achieve 70% of correct choices and four sessions were used to the analyses. We then analyzed intervals of inter­trial period (DELAY), decision­making (DM), and running to reward (RUN). Trials with similar locomotion speed were used to compare theta power across intervals. We measured cross­frequency coupling within each interval and temporally triggered to the end of DM. Resultados e Conclusões We observed prominent theta oscillations and strong phase modulation of gamma amplitude during DM interval of the task, which occurred in the center of the maze before animals deliberately ran through an arm towards goal location. In speed-controlled analyses, theta power and frequency were higher during the decision period when compared to either an inter­trial delay period (also at the maze center), or to the period of running towards goal location (p<0.05, two­way ANOVA followed by Tukey's post hoc test). Moreover, theta activity was higher during decision intervals preceding correct choices than during decision intervals preceding incorrect choices (p<0.05, Student's t­test). Altogether, our data support a cognitive function for the hippocampal theta rhythm in spatial decision­making.
format conferenceObject
author Belchior, Hindiael
Souza, Bryan
Santos, Vítor Lopes dos
Ribeiro, Sidarta Tollendal Gomes
Tort, Adriano Bretanha Lopes
author_facet Belchior, Hindiael
Souza, Bryan
Santos, Vítor Lopes dos
Ribeiro, Sidarta Tollendal Gomes
Tort, Adriano Bretanha Lopes
author_sort Belchior, Hindiael
title Hippocampal Theta Oscillations and Cross-Frequency Coupling during Spatial Decision-Making
title_short Hippocampal Theta Oscillations and Cross-Frequency Coupling during Spatial Decision-Making
title_full Hippocampal Theta Oscillations and Cross-Frequency Coupling during Spatial Decision-Making
title_fullStr Hippocampal Theta Oscillations and Cross-Frequency Coupling during Spatial Decision-Making
title_full_unstemmed Hippocampal Theta Oscillations and Cross-Frequency Coupling during Spatial Decision-Making
title_sort hippocampal theta oscillations and cross-frequency coupling during spatial decision-making
publishDate 2017
url https://repositorio.ufrn.br/jspui/handle/123456789/24247
work_keys_str_mv AT belchiorhindiael hippocampalthetaoscillationsandcrossfrequencycouplingduringspatialdecisionmaking
AT souzabryan hippocampalthetaoscillationsandcrossfrequencycouplingduringspatialdecisionmaking
AT santosvitorlopesdos hippocampalthetaoscillationsandcrossfrequencycouplingduringspatialdecisionmaking
AT ribeirosidartatollendalgomes hippocampalthetaoscillationsandcrossfrequencycouplingduringspatialdecisionmaking
AT tortadrianobretanhalopes hippocampalthetaoscillationsandcrossfrequencycouplingduringspatialdecisionmaking
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