Prevention of oral lesions in children with acute lymphoblastic leukemia

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Acute lymphoblastic leukemia (ALL) is the most common form of cancer in children and is responsible for severe stomatologic complications. Treatment consists of four phases of chemotherapy, the main side effect of methotrexate, the drug most used during the intensification phase, is oral mucositis....

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Principais autores: Pinto, Leao Pereira, Souza, Lelia Batista de, Gordón-Núñez, Manuel Antonio, Soares, Rosilene Calasanz, Costa, Edja Maria Melo de Brito, Aquino, Ana Rafaela Luz de, Fernandes, Maria Zélia
Formato: article
Idioma:eng
Publicado em: ELSEVIER
Assuntos:
Leukemia
Chlorexidine
Oral mucosa
Oral lesions
Oral mucositis
Chemotherapy
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/23893
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spelling ri-123456789-238932023-02-08T19:15:04Z Prevention of oral lesions in children with acute lymphoblastic leukemia Pinto, Leao Pereira Souza, Lelia Batista de Gordón-Núñez, Manuel Antonio Soares, Rosilene Calasanz Costa, Edja Maria Melo de Brito Aquino, Ana Rafaela Luz de Fernandes, Maria Zélia Leukemia Chlorexidine Oral mucosa Oral lesions Oral mucositis Chemotherapy Acute lymphoblastic leukemia (ALL) is the most common form of cancer in children and is responsible for severe stomatologic complications. Treatment consists of four phases of chemotherapy, the main side effect of methotrexate, the drug most used during the intensification phase, is oral mucositis. OBJECTIVE: To evaluate the clinical aspects of the oral mucosa of children with ALL and to determine the effect of 0.12% chlorhexidine gluconate on the prevention of stomatologic complications in these patients. PATIENTS AND METHODS: Thirty-three children treated for ALL ranging in age from 2 to 15 years, without distinction of gender or race, were submitted to visual examination, digital palpation of the oral mucosa and cytologic examination of the buccal mucosa, and divided into two groups: group I consisted of 23 children using an oral solution of 0.12% chlorhexidine gluconate twice a day, and group II consisted of 10 children who did not receive this solution. All children received daily oral hygiene care guided by the dentist throughout treatment. RESULTS: Mucositis was observed in six children of group I and eight of group II, and was characterized by erythema, edema and ulcers. Uniform cytologic findings were obtained for the two groups, with a clear predominance of cells of the intermediate layer in all smears, in addition to a perinuclear halo in 18% of the smears. CONCLUSION: The present results suggest that systematic preventive treatment with 0.12% chlorhexidine gluconate and oral hygiene care reduce the occurrence of oral complications in children with ALL undergoing antineoplastic chemotherapy. 2017-09-15T13:52:39Z 2017-09-15T13:52:39Z 2006 article PINTO, Leão Pereira et al. Prevention of oral lesions in children with acute lymphoblastic leukemia. International Journal of Pediatric Otorhinolaryngology, v. 70, n. 11, p. 1847-1851, 2006. https://repositorio.ufrn.br/jspui/handle/123456789/23893 10.1016/j.ijporl.2006.04.016 eng ELSEVIER
institution Repositório Institucional
collection RI - UFRN
language eng
topic Leukemia
Chlorexidine
Oral mucosa
Oral lesions
Oral mucositis
Chemotherapy
spellingShingle Leukemia
Chlorexidine
Oral mucosa
Oral lesions
Oral mucositis
Chemotherapy
Pinto, Leao Pereira
Souza, Lelia Batista de
Gordón-Núñez, Manuel Antonio
Soares, Rosilene Calasanz
Costa, Edja Maria Melo de Brito
Aquino, Ana Rafaela Luz de
Fernandes, Maria Zélia
Prevention of oral lesions in children with acute lymphoblastic leukemia
description Acute lymphoblastic leukemia (ALL) is the most common form of cancer in children and is responsible for severe stomatologic complications. Treatment consists of four phases of chemotherapy, the main side effect of methotrexate, the drug most used during the intensification phase, is oral mucositis. OBJECTIVE: To evaluate the clinical aspects of the oral mucosa of children with ALL and to determine the effect of 0.12% chlorhexidine gluconate on the prevention of stomatologic complications in these patients. PATIENTS AND METHODS: Thirty-three children treated for ALL ranging in age from 2 to 15 years, without distinction of gender or race, were submitted to visual examination, digital palpation of the oral mucosa and cytologic examination of the buccal mucosa, and divided into two groups: group I consisted of 23 children using an oral solution of 0.12% chlorhexidine gluconate twice a day, and group II consisted of 10 children who did not receive this solution. All children received daily oral hygiene care guided by the dentist throughout treatment. RESULTS: Mucositis was observed in six children of group I and eight of group II, and was characterized by erythema, edema and ulcers. Uniform cytologic findings were obtained for the two groups, with a clear predominance of cells of the intermediate layer in all smears, in addition to a perinuclear halo in 18% of the smears. CONCLUSION: The present results suggest that systematic preventive treatment with 0.12% chlorhexidine gluconate and oral hygiene care reduce the occurrence of oral complications in children with ALL undergoing antineoplastic chemotherapy.
format article
author Pinto, Leao Pereira
Souza, Lelia Batista de
Gordón-Núñez, Manuel Antonio
Soares, Rosilene Calasanz
Costa, Edja Maria Melo de Brito
Aquino, Ana Rafaela Luz de
Fernandes, Maria Zélia
author_facet Pinto, Leao Pereira
Souza, Lelia Batista de
Gordón-Núñez, Manuel Antonio
Soares, Rosilene Calasanz
Costa, Edja Maria Melo de Brito
Aquino, Ana Rafaela Luz de
Fernandes, Maria Zélia
author_sort Pinto, Leao Pereira
title Prevention of oral lesions in children with acute lymphoblastic leukemia
title_short Prevention of oral lesions in children with acute lymphoblastic leukemia
title_full Prevention of oral lesions in children with acute lymphoblastic leukemia
title_fullStr Prevention of oral lesions in children with acute lymphoblastic leukemia
title_full_unstemmed Prevention of oral lesions in children with acute lymphoblastic leukemia
title_sort prevention of oral lesions in children with acute lymphoblastic leukemia
publisher ELSEVIER
publishDate 2017
url https://repositorio.ufrn.br/jspui/handle/123456789/23893
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