Immunohistochemical expression of vimentin, calponin and HHF-35 in salivary gland tumors

Myoepithelial cells present a complex immunophenotype, with the expression of proteins varying according to the stage of normal or neoplastic differentiation of the cell. In order to evaluate the immunohistochemical markers expressed by these cells, a panel of antibodies composed of vimentin, calpon...

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Principais autores: Souza, Lélia Batista de, Cavalcante, Roberta Barroso, Lopes, Fernanda Ferreira, Soares, Andréa Ferreira, Freitas, Roseana de Almeida
Formato: article
Idioma:eng
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Assuntos:
Myoepithelial cell
Salivary gland tumors
Vimentin
Calponin
HHF-35
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/23888
http://dx.doi.org/10.1590/S0103-64402007000300003
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spelling ri-123456789-238882021-12-09T15:53:34Z Immunohistochemical expression of vimentin, calponin and HHF-35 in salivary gland tumors Souza, Lélia Batista de Cavalcante, Roberta Barroso Lopes, Fernanda Ferreira Soares, Andréa Ferreira Freitas, Roseana de Almeida Myoepithelial cell Salivary gland tumors Vimentin Calponin HHF-35 Myoepithelial cells present a complex immunophenotype, with the expression of proteins varying according to the stage of normal or neoplastic differentiation of the cell. In order to evaluate the immunohistochemical markers expressed by these cells, a panel of antibodies composed of vimentin, calponin and HHF-35 was applied to 28 salivary gland tumors. The results demonstrated a higher percent sensitivity of vimentin and calponin compared to HHF-35. However, calponin and HHF-35 presented a focal labeling pattern in contrast with the diffuse distribution of vimentin. The cells predominantly stained by all tested antibodies included nonluminal cells in duct-like and tubular structures, such as those seen in pleomorphic adenomas and adenoid cystic carcinomas, as well as cells in the cords and nests of polymorphous low-grade adenocarcinomas and peripheral cells of sheets and nests of myoepitheliomas. In conclusion, the combination of calponin and vimentin is suggested for the identification of myoepithelial cells in salivary gland tumors. 2017-09-15T13:44:14Z 2017-09-15T13:44:14Z 2007 article SOUZA, Lélia Batista de et al . Immunohistochemical expression of vimentin, calponin and HHF-35 in salivary gland tumors. Brazilian Dental Journal, v. 10, n. 3, p. 38-42, 2007. https://repositorio.ufrn.br/jspui/handle/123456789/23888 http://dx.doi.org/10.1590/S0103-64402007000300003 eng Acesso Aberto application/pdf
institution Repositório Institucional
collection RI - UFRN
language eng
topic Myoepithelial cell
Salivary gland tumors
Vimentin
Calponin
HHF-35
spellingShingle Myoepithelial cell
Salivary gland tumors
Vimentin
Calponin
HHF-35
Souza, Lélia Batista de
Cavalcante, Roberta Barroso
Lopes, Fernanda Ferreira
Soares, Andréa Ferreira
Freitas, Roseana de Almeida
Immunohistochemical expression of vimentin, calponin and HHF-35 in salivary gland tumors
description Myoepithelial cells present a complex immunophenotype, with the expression of proteins varying according to the stage of normal or neoplastic differentiation of the cell. In order to evaluate the immunohistochemical markers expressed by these cells, a panel of antibodies composed of vimentin, calponin and HHF-35 was applied to 28 salivary gland tumors. The results demonstrated a higher percent sensitivity of vimentin and calponin compared to HHF-35. However, calponin and HHF-35 presented a focal labeling pattern in contrast with the diffuse distribution of vimentin. The cells predominantly stained by all tested antibodies included nonluminal cells in duct-like and tubular structures, such as those seen in pleomorphic adenomas and adenoid cystic carcinomas, as well as cells in the cords and nests of polymorphous low-grade adenocarcinomas and peripheral cells of sheets and nests of myoepitheliomas. In conclusion, the combination of calponin and vimentin is suggested for the identification of myoepithelial cells in salivary gland tumors.
format article
author Souza, Lélia Batista de
Cavalcante, Roberta Barroso
Lopes, Fernanda Ferreira
Soares, Andréa Ferreira
Freitas, Roseana de Almeida
author_facet Souza, Lélia Batista de
Cavalcante, Roberta Barroso
Lopes, Fernanda Ferreira
Soares, Andréa Ferreira
Freitas, Roseana de Almeida
author_sort Souza, Lélia Batista de
title Immunohistochemical expression of vimentin, calponin and HHF-35 in salivary gland tumors
title_short Immunohistochemical expression of vimentin, calponin and HHF-35 in salivary gland tumors
title_full Immunohistochemical expression of vimentin, calponin and HHF-35 in salivary gland tumors
title_fullStr Immunohistochemical expression of vimentin, calponin and HHF-35 in salivary gland tumors
title_full_unstemmed Immunohistochemical expression of vimentin, calponin and HHF-35 in salivary gland tumors
title_sort immunohistochemical expression of vimentin, calponin and hhf-35 in salivary gland tumors
publishDate 2017
url https://repositorio.ufrn.br/jspui/handle/123456789/23888
http://dx.doi.org/10.1590/S0103-64402007000300003
work_keys_str_mv AT souzaleliabatistade immunohistochemicalexpressionofvimentincalponinandhhf35insalivaryglandtumors
AT cavalcanterobertabarroso immunohistochemicalexpressionofvimentincalponinandhhf35insalivaryglandtumors
AT lopesfernandaferreira immunohistochemicalexpressionofvimentincalponinandhhf35insalivaryglandtumors
AT soaresandreaferreira immunohistochemicalexpressionofvimentincalponinandhhf35insalivaryglandtumors
AT freitasroseanadealmeida immunohistochemicalexpressionofvimentincalponinandhhf35insalivaryglandtumors
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