Immunohistochemical profile of integrins in enlarged dental follicles and dentigerous cysts

OBJECTIVE AND STUDY DESIGN: The morphological distinction between incipient dentigerous cyst (IDC) and enlarged pericoronal dental follicle (EDF) remains one of the most controversial questions in the literature. The objective of this study was to analyze the immunohistochemistry expression of alfa...

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Principais autores: Godoy, Gustavo Pina, Silveira, Éricka Janine Dantas da, Lins, Ruthinéia Diógenes Alves Uchoa, Souza, Lélia Batista de, Freitas, Roseana de Almeida
Formato: article
Idioma:eng
Publicado em: ELSEVIER
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Immunohistochemical
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/23887
https://doi.org/10.1016/j.tripleo.2007.05.024
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spelling ri-123456789-238872017-11-04T23:28:55Z Immunohistochemical profile of integrins in enlarged dental follicles and dentigerous cysts Godoy, Gustavo Pina Silveira, Éricka Janine Dantas da Lins, Ruthinéia Diógenes Alves Uchoa Souza, Lélia Batista de Freitas, Roseana de Almeida Immunohistochemical OBJECTIVE AND STUDY DESIGN: The morphological distinction between incipient dentigerous cyst (IDC) and enlarged pericoronal dental follicle (EDF) remains one of the most controversial questions in the literature. The objective of this study was to analyze the immunohistochemistry expression of alfa(2)beta(1), alfa(3)beta(1), and alfa(5)beta(1) in 23 cases of EDFs and 21 cases of IDCs. RESULTS: All integrins were immunopositive in the cases studied. A significant difference was detected regarding alfa(2)beta(1) integrin (P < .0001) in which a higher expression was present in IDCs. Moreover, statistical difference was also found between basal and suprabasal cell layer in cystic epithelium (P < .0034). The alfa(3)beta(1) integrin expression showed significant difference (P < .013) between EDF and IDC with a tendency of more pronounced staining in IDC. CONCLUSIONS: These results corroborate the possibility of histopathological distinction between EDF and IDC in which squamous metaplasia of reduced enamel epithelium to stratified epithelium would be the first event of cystic transformation. 2017-09-15T13:43:35Z 2017-09-15T13:43:35Z 2007 article GODOY, Gustavo Pina et al. Immunohistochemical profile of integrins in enlarged dental follicles and dentigerous cysts. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics, v. 104, n. 6, p. 29-34, 2007. https://repositorio.ufrn.br/jspui/handle/123456789/23887 https://doi.org/10.1016/j.tripleo.2007.05.024 eng Acesso Aberto application/pdf ELSEVIER
institution Repositório Institucional
collection RI - UFRN
language eng
topic Immunohistochemical
spellingShingle Immunohistochemical
Godoy, Gustavo Pina
Silveira, Éricka Janine Dantas da
Lins, Ruthinéia Diógenes Alves Uchoa
Souza, Lélia Batista de
Freitas, Roseana de Almeida
Immunohistochemical profile of integrins in enlarged dental follicles and dentigerous cysts
description OBJECTIVE AND STUDY DESIGN: The morphological distinction between incipient dentigerous cyst (IDC) and enlarged pericoronal dental follicle (EDF) remains one of the most controversial questions in the literature. The objective of this study was to analyze the immunohistochemistry expression of alfa(2)beta(1), alfa(3)beta(1), and alfa(5)beta(1) in 23 cases of EDFs and 21 cases of IDCs. RESULTS: All integrins were immunopositive in the cases studied. A significant difference was detected regarding alfa(2)beta(1) integrin (P < .0001) in which a higher expression was present in IDCs. Moreover, statistical difference was also found between basal and suprabasal cell layer in cystic epithelium (P < .0034). The alfa(3)beta(1) integrin expression showed significant difference (P < .013) between EDF and IDC with a tendency of more pronounced staining in IDC. CONCLUSIONS: These results corroborate the possibility of histopathological distinction between EDF and IDC in which squamous metaplasia of reduced enamel epithelium to stratified epithelium would be the first event of cystic transformation.
format article
author Godoy, Gustavo Pina
Silveira, Éricka Janine Dantas da
Lins, Ruthinéia Diógenes Alves Uchoa
Souza, Lélia Batista de
Freitas, Roseana de Almeida
author_facet Godoy, Gustavo Pina
Silveira, Éricka Janine Dantas da
Lins, Ruthinéia Diógenes Alves Uchoa
Souza, Lélia Batista de
Freitas, Roseana de Almeida
author_sort Godoy, Gustavo Pina
title Immunohistochemical profile of integrins in enlarged dental follicles and dentigerous cysts
title_short Immunohistochemical profile of integrins in enlarged dental follicles and dentigerous cysts
title_full Immunohistochemical profile of integrins in enlarged dental follicles and dentigerous cysts
title_fullStr Immunohistochemical profile of integrins in enlarged dental follicles and dentigerous cysts
title_full_unstemmed Immunohistochemical profile of integrins in enlarged dental follicles and dentigerous cysts
title_sort immunohistochemical profile of integrins in enlarged dental follicles and dentigerous cysts
publisher ELSEVIER
publishDate 2017
url https://repositorio.ufrn.br/jspui/handle/123456789/23887
https://doi.org/10.1016/j.tripleo.2007.05.024
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