Immunohistochemical expression of MMPs 1, 7 and 26 in syndrome and nonsyndrome odontogenic keratocysts

Objective. The objective of this study was to analyze the expression of matrix metalloproteinases (MMPs) 1, 7, and 26 in odontogenic keratocysts (OKCs) associated with Gorlin syndrome (SOKCs) and nonsyndrome OKCs (NSOKCs). Study design. Twenty-one SOKCs and 20 NSOKCs were evaluated for epithelial ex...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Principais autores: Cavalcante, Roberta Barroso, Alves, Karuza Maria, Nonaka, Cassiano Francisco Weege, Souza, Lélia Batista de
Formato: article
Idioma:eng
Publicado em:
Assuntos:
Immunohistochemistry
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/23860
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
id ri-123456789-23860
record_format dspace
spelling ri-123456789-238602021-12-09T16:16:21Z Immunohistochemical expression of MMPs 1, 7 and 26 in syndrome and nonsyndrome odontogenic keratocysts Cavalcante, Roberta Barroso Alves, Karuza Maria Nonaka, Cassiano Francisco Weege Souza, Lélia Batista de Immunohistochemistry Objective. The objective of this study was to analyze the expression of matrix metalloproteinases (MMPs) 1, 7, and 26 in odontogenic keratocysts (OKCs) associated with Gorlin syndrome (SOKCs) and nonsyndrome OKCs (NSOKCs). Study design. Twenty-one SOKCs and 20 NSOKCs were evaluated for epithelial expression of MMP-1, MMP-7, and MMP-26 and for mesenchymal expression of MMP-1 by immunohistochemistry. Results. Strong epithelial positivity to MMP-1 was observed in 76% of SOKCs and in 15% of NSOKCs (P .05). Strong mesenchymal immunoreactivity to MMP-1 was observed in 38% of SOKCs and in 20% of NSOKCs (P .05). Epithelial immunoreactivity to MMP-7 was strongly positive in 67% of SOKCs and in 40% of NSOKCs (P .05). For MMP-26, strong positivity was found in 62% of SOKCs, in contrast to 35% of NSOKCs (P .05). Conclusion. MMPs-1, 7 and 26 may play important roles in the biology of OKCs. Furthermore, the presence of these proteases at higher levels in SOKCs may help to explain increased OKC aggressiveness associated with nevoid basal cell carcinoma syndrome. 2017-09-13T15:24:47Z 2017-09-13T15:24:47Z 2008 article CAVALCANTE, Roberta Barroso et al . Immunohistochemical expression of MMPs 1, 7 and 26 in syndrome and nonsyndrome odontogenic keratocysts. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics , v. 106, n. 1, p. 923-929, 2008. https://repositorio.ufrn.br/jspui/handle/123456789/23860 10.1016/j.tripleo.2007.12.028 eng Acesso Aberto application/pdf
institution Repositório Institucional
collection RI - UFRN
language eng
topic Immunohistochemistry
spellingShingle Immunohistochemistry
Cavalcante, Roberta Barroso
Alves, Karuza Maria
Nonaka, Cassiano Francisco Weege
Souza, Lélia Batista de
Immunohistochemical expression of MMPs 1, 7 and 26 in syndrome and nonsyndrome odontogenic keratocysts
description Objective. The objective of this study was to analyze the expression of matrix metalloproteinases (MMPs) 1, 7, and 26 in odontogenic keratocysts (OKCs) associated with Gorlin syndrome (SOKCs) and nonsyndrome OKCs (NSOKCs). Study design. Twenty-one SOKCs and 20 NSOKCs were evaluated for epithelial expression of MMP-1, MMP-7, and MMP-26 and for mesenchymal expression of MMP-1 by immunohistochemistry. Results. Strong epithelial positivity to MMP-1 was observed in 76% of SOKCs and in 15% of NSOKCs (P .05). Strong mesenchymal immunoreactivity to MMP-1 was observed in 38% of SOKCs and in 20% of NSOKCs (P .05). Epithelial immunoreactivity to MMP-7 was strongly positive in 67% of SOKCs and in 40% of NSOKCs (P .05). For MMP-26, strong positivity was found in 62% of SOKCs, in contrast to 35% of NSOKCs (P .05). Conclusion. MMPs-1, 7 and 26 may play important roles in the biology of OKCs. Furthermore, the presence of these proteases at higher levels in SOKCs may help to explain increased OKC aggressiveness associated with nevoid basal cell carcinoma syndrome.
format article
author Cavalcante, Roberta Barroso
Alves, Karuza Maria
Nonaka, Cassiano Francisco Weege
Souza, Lélia Batista de
author_facet Cavalcante, Roberta Barroso
Alves, Karuza Maria
Nonaka, Cassiano Francisco Weege
Souza, Lélia Batista de
author_sort Cavalcante, Roberta Barroso
title Immunohistochemical expression of MMPs 1, 7 and 26 in syndrome and nonsyndrome odontogenic keratocysts
title_short Immunohistochemical expression of MMPs 1, 7 and 26 in syndrome and nonsyndrome odontogenic keratocysts
title_full Immunohistochemical expression of MMPs 1, 7 and 26 in syndrome and nonsyndrome odontogenic keratocysts
title_fullStr Immunohistochemical expression of MMPs 1, 7 and 26 in syndrome and nonsyndrome odontogenic keratocysts
title_full_unstemmed Immunohistochemical expression of MMPs 1, 7 and 26 in syndrome and nonsyndrome odontogenic keratocysts
title_sort immunohistochemical expression of mmps 1, 7 and 26 in syndrome and nonsyndrome odontogenic keratocysts
publishDate 2017
url https://repositorio.ufrn.br/jspui/handle/123456789/23860
work_keys_str_mv AT cavalcanterobertabarroso immunohistochemicalexpressionofmmps17and26insyndromeandnonsyndromeodontogenickeratocysts
AT alveskaruzamaria immunohistochemicalexpressionofmmps17and26insyndromeandnonsyndromeodontogenickeratocysts
AT nonakacassianofranciscoweege immunohistochemicalexpressionofmmps17and26insyndromeandnonsyndromeodontogenickeratocysts
AT souzaleliabatistade immunohistochemicalexpressionofmmps17and26insyndromeandnonsyndromeodontogenickeratocysts
_version_ 1773963403451170816

Registros relacionados