Bone morphogenetic protein-2/4 and bone morphogenetic protein receptor type IA expression in metastatic and nonmetastatic oral squamous cell carcinoma

Purpose The study aimed to analyze the expression of bone morphogenetic protein-2/4 (BMP-2/4) and its receptor BMPR-IA (BMP receptor type IA) in metastatic and nonmetastatic oral squamous cell carcinoma (OSCC) and its implications for disease prognosis. Materials and methods The experimenta...

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Principais autores: Soares, Andréa Ferreira, Xavier, Ruth Lopes de Freitas, Miguel, Márcia Cristina da Costa, Souza, Lélia Batista de, Pinto, Leão Pereira
Formato: article
Idioma:eng
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Bone morphogenetic protein-4
Squamous cell carcinoma of the head and neck
Epithelial-mesenchymal transition
Invasiveness
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/23812
https://doi.org/10.1016/j.amjoto.2009.03.002
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spelling ri-123456789-238122022-12-13T23:09:49Z Bone morphogenetic protein-2/4 and bone morphogenetic protein receptor type IA expression in metastatic and nonmetastatic oral squamous cell carcinoma Soares, Andréa Ferreira Xavier, Ruth Lopes de Freitas Miguel, Márcia Cristina da Costa Souza, Lélia Batista de Pinto, Leão Pereira Bone morphogenetic protein-4 Squamous cell carcinoma of the head and neck Epithelial-mesenchymal transition Invasiveness Purpose The study aimed to analyze the expression of bone morphogenetic protein-2/4 (BMP-2/4) and its receptor BMPR-IA (BMP receptor type IA) in metastatic and nonmetastatic oral squamous cell carcinoma (OSCC) and its implications for disease prognosis. Materials and methods The experimental group included 16 cases of OSCC without metastasis and 7 cases of OSCC with metastasis. The presence or absence of nodal metastasis was used as a parameter for the evaluation of disease prognosis. Ten cases of oral fibroepithelial hyperplasia were selected as the control group. The expression of BMP-2/4 and BMPR-IA was analyzed by immunohistochemistry. Results In the experimental group with metastasis, strong expression of BMP-2/4 was observed in most cases (71.4%), whereas BMPR-IA exhibited weak expression (85.7%). In the experimental group without metastasis, there was strong expression of BMP-2/4 (62.5%) and BMPR-IA (100%). A significant association was observed between the prognosis of OSCC and the intensity of BMP-2/4 staining (P = .002). Weak immunoreactivity to BMP-2/4 and BMPR-IA was observed in all control specimens. Conclusions The results suggest that strong expression of BMP-2/4, associated with low expression of BMPR-IA, observed in metastatic OSCC has a prognostic value, with the loss of responsiveness to BMPs through the loss of expression of their receptors being indicative of the development of metastasis. 2017-09-11T14:43:55Z 2017-09-11T14:43:55Z 2010 article SOARES, Andréa Ferreira et al. Bone morphogenetic protein-2/4 and bone morphogenetic protein receptor type IA expression in metastatic and nonmetastatic oral squamous cell carcinoma. American Journal of Otolaryngology, v. 31, n. 4, p. 266-271, 2010. https://repositorio.ufrn.br/jspui/handle/123456789/23812 https://doi.org/10.1016/j.amjoto.2009.03.002 eng Acesso Aberto
institution Repositório Institucional
collection RI - UFRN
language eng
topic Bone morphogenetic protein-4
Squamous cell carcinoma of the head and neck
Epithelial-mesenchymal transition
Invasiveness
spellingShingle Bone morphogenetic protein-4
Squamous cell carcinoma of the head and neck
Epithelial-mesenchymal transition
Invasiveness
Soares, Andréa Ferreira
Xavier, Ruth Lopes de Freitas
Miguel, Márcia Cristina da Costa
Souza, Lélia Batista de
Pinto, Leão Pereira
Bone morphogenetic protein-2/4 and bone morphogenetic protein receptor type IA expression in metastatic and nonmetastatic oral squamous cell carcinoma
description Purpose The study aimed to analyze the expression of bone morphogenetic protein-2/4 (BMP-2/4) and its receptor BMPR-IA (BMP receptor type IA) in metastatic and nonmetastatic oral squamous cell carcinoma (OSCC) and its implications for disease prognosis. Materials and methods The experimental group included 16 cases of OSCC without metastasis and 7 cases of OSCC with metastasis. The presence or absence of nodal metastasis was used as a parameter for the evaluation of disease prognosis. Ten cases of oral fibroepithelial hyperplasia were selected as the control group. The expression of BMP-2/4 and BMPR-IA was analyzed by immunohistochemistry. Results In the experimental group with metastasis, strong expression of BMP-2/4 was observed in most cases (71.4%), whereas BMPR-IA exhibited weak expression (85.7%). In the experimental group without metastasis, there was strong expression of BMP-2/4 (62.5%) and BMPR-IA (100%). A significant association was observed between the prognosis of OSCC and the intensity of BMP-2/4 staining (P = .002). Weak immunoreactivity to BMP-2/4 and BMPR-IA was observed in all control specimens. Conclusions The results suggest that strong expression of BMP-2/4, associated with low expression of BMPR-IA, observed in metastatic OSCC has a prognostic value, with the loss of responsiveness to BMPs through the loss of expression of their receptors being indicative of the development of metastasis.
format article
author Soares, Andréa Ferreira
Xavier, Ruth Lopes de Freitas
Miguel, Márcia Cristina da Costa
Souza, Lélia Batista de
Pinto, Leão Pereira
author_facet Soares, Andréa Ferreira
Xavier, Ruth Lopes de Freitas
Miguel, Márcia Cristina da Costa
Souza, Lélia Batista de
Pinto, Leão Pereira
author_sort Soares, Andréa Ferreira
title Bone morphogenetic protein-2/4 and bone morphogenetic protein receptor type IA expression in metastatic and nonmetastatic oral squamous cell carcinoma
title_short Bone morphogenetic protein-2/4 and bone morphogenetic protein receptor type IA expression in metastatic and nonmetastatic oral squamous cell carcinoma
title_full Bone morphogenetic protein-2/4 and bone morphogenetic protein receptor type IA expression in metastatic and nonmetastatic oral squamous cell carcinoma
title_fullStr Bone morphogenetic protein-2/4 and bone morphogenetic protein receptor type IA expression in metastatic and nonmetastatic oral squamous cell carcinoma
title_full_unstemmed Bone morphogenetic protein-2/4 and bone morphogenetic protein receptor type IA expression in metastatic and nonmetastatic oral squamous cell carcinoma
title_sort bone morphogenetic protein-2/4 and bone morphogenetic protein receptor type ia expression in metastatic and nonmetastatic oral squamous cell carcinoma
publishDate 2017
url https://repositorio.ufrn.br/jspui/handle/123456789/23812
https://doi.org/10.1016/j.amjoto.2009.03.002
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