Human papillomavirus in oral squamous cells carcinoma in a population of 75 Brazilian patients

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Purpose In the present study, we investigated the presence of human papillomavirus (HPV) DNA and viral types in 75 cases of oral squamous cells carcinoma from Brazil to obtain data that would contribute to a better understanding of the role of HPV in the pathogenesis of this tumor. Materials a...

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Principais autores: Soares, Rosilene Calazans, Oliveira, Márcio Campos, Souza, Lélia Batista de, Costa, Antonio de Lisboa Lopes, Medeiros, Sílvia Regina Batistuzzo de, Pinto, Leão Pereira
Formato: article
Idioma:eng
Publicado em: ELSEVIER
Assuntos:
Papillomaviridae
Carcinoma
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/23796
https://doi.org/10.1016/j.amjoto.2006.11.012
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spelling ri-123456789-237962023-01-31T19:51:59Z Human papillomavirus in oral squamous cells carcinoma in a population of 75 Brazilian patients Soares, Rosilene Calazans Oliveira, Márcio Campos Souza, Lélia Batista de Costa, Antonio de Lisboa Lopes Medeiros, Sílvia Regina Batistuzzo de Pinto, Leão Pereira Papillomaviridae Carcinoma Purpose In the present study, we investigated the presence of human papillomavirus (HPV) DNA and viral types in 75 cases of oral squamous cells carcinoma from Brazil to obtain data that would contribute to a better understanding of the role of HPV in the pathogenesis of this tumor. Materials and methods DNA was extracted from paraffin-embedded tissue and amplified by polymerase chain reaction using a pair of primers designated PCO3+ and PCO4+ for the detection of a fragment of the human β-globin gene, followed by polymerase chain reaction for the detection of HPV DNA using a pair of generic primers, GP5+ and GP6+. Viral typing was performed by dot blot hybridization. Results Human papillomavirus DNA was detected in 18 (24%) of the 75 cases positive for the human β-globin gene. No significant association was observed between HPV and age, sex, or anatomical location of the tumor. The most prevalent viral type was HPV-18 (77,8%). Conclusion The low frequency of detection of HPV DNA in oral epidermoid carcinomas suggests a possible participation of the virus in the development and progression of only a subgroup of these tumors. 2017-09-11T12:40:59Z 2017-09-11T12:40:59Z 2007 article SOARES, Rosilene Calazans et al. Human papillomavirus in oral squamous cells carcinoma in a population of 75 brazilian patients. American Journal of Otolaryngology, v. 28, n. 6, p. 397-400, 2007. https://repositorio.ufrn.br/jspui/handle/123456789/23796 https://doi.org/10.1016/j.amjoto.2006.11.012 eng Acesso Aberto ELSEVIER
institution Repositório Institucional
collection RI - UFRN
language eng
topic Papillomaviridae
Carcinoma
spellingShingle Papillomaviridae
Carcinoma
Soares, Rosilene Calazans
Oliveira, Márcio Campos
Souza, Lélia Batista de
Costa, Antonio de Lisboa Lopes
Medeiros, Sílvia Regina Batistuzzo de
Pinto, Leão Pereira
Human papillomavirus in oral squamous cells carcinoma in a population of 75 Brazilian patients
description Purpose In the present study, we investigated the presence of human papillomavirus (HPV) DNA and viral types in 75 cases of oral squamous cells carcinoma from Brazil to obtain data that would contribute to a better understanding of the role of HPV in the pathogenesis of this tumor. Materials and methods DNA was extracted from paraffin-embedded tissue and amplified by polymerase chain reaction using a pair of primers designated PCO3+ and PCO4+ for the detection of a fragment of the human β-globin gene, followed by polymerase chain reaction for the detection of HPV DNA using a pair of generic primers, GP5+ and GP6+. Viral typing was performed by dot blot hybridization. Results Human papillomavirus DNA was detected in 18 (24%) of the 75 cases positive for the human β-globin gene. No significant association was observed between HPV and age, sex, or anatomical location of the tumor. The most prevalent viral type was HPV-18 (77,8%). Conclusion The low frequency of detection of HPV DNA in oral epidermoid carcinomas suggests a possible participation of the virus in the development and progression of only a subgroup of these tumors.
format article
author Soares, Rosilene Calazans
Oliveira, Márcio Campos
Souza, Lélia Batista de
Costa, Antonio de Lisboa Lopes
Medeiros, Sílvia Regina Batistuzzo de
Pinto, Leão Pereira
author_facet Soares, Rosilene Calazans
Oliveira, Márcio Campos
Souza, Lélia Batista de
Costa, Antonio de Lisboa Lopes
Medeiros, Sílvia Regina Batistuzzo de
Pinto, Leão Pereira
author_sort Soares, Rosilene Calazans
title Human papillomavirus in oral squamous cells carcinoma in a population of 75 Brazilian patients
title_short Human papillomavirus in oral squamous cells carcinoma in a population of 75 Brazilian patients
title_full Human papillomavirus in oral squamous cells carcinoma in a population of 75 Brazilian patients
title_fullStr Human papillomavirus in oral squamous cells carcinoma in a population of 75 Brazilian patients
title_full_unstemmed Human papillomavirus in oral squamous cells carcinoma in a population of 75 Brazilian patients
title_sort human papillomavirus in oral squamous cells carcinoma in a population of 75 brazilian patients
publisher ELSEVIER
publishDate 2017
url https://repositorio.ufrn.br/jspui/handle/123456789/23796
https://doi.org/10.1016/j.amjoto.2006.11.012
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