Decreased neuron loss and memory dysfunction in pilocarpine-treated rats pre-exposed to hypoxia

Preconditioning can induce a cascade of cellular events leading to neuroprotection against subsequent brain insults. In this study, we investigated the chronic effects of hypoxic preconditioning on spontaneous recurrent seizures (SRS), neuronal death, and spatial memory performance in rats subjected...

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Principais autores: Do Val-da Silva, RA, Peixoto-Santos, JE, Scandiuzzi, RC, Balista, PA, Bassi, M, Glass, ML, Romcy-Pereira, Rodrigo Neves, Galvis-Alonso, OY, Leite, JP
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Idioma:eng
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Assuntos:
hypoxic preconditioning
memory deficit
mossy fiber sprouting
neuronal death
pilocarpine-induced status epilepticus
temporal lobe epilepsy
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/23366
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spelling ri-123456789-233662021-07-09T22:30:48Z Decreased neuron loss and memory dysfunction in pilocarpine-treated rats pre-exposed to hypoxia Do Val-da Silva, RA Peixoto-Santos, JE Scandiuzzi, RC Balista, PA Bassi, M Glass, ML Romcy-Pereira, Rodrigo Neves Galvis-Alonso, OY Leite, JP hypoxic preconditioning memory deficit mossy fiber sprouting neuronal death pilocarpine-induced status epilepticus temporal lobe epilepsy Preconditioning can induce a cascade of cellular events leading to neuroprotection against subsequent brain insults. In this study, we investigated the chronic effects of hypoxic preconditioning on spontaneous recurrent seizures (SRS), neuronal death, and spatial memory performance in rats subjected to pilocarpine (Pilo)-induced status epilepticus (SE). Rats underwent a short hypoxic episode (7% O2+93% N2; 30min on two consecutive days) preceding a 4-h SE (HSE group). Control groups were rats submitted to SE only (SE), rats subjected to hypoxia only (H) or normoxia-saline (C). Animals were monitored for the occurrence of SRS, and spatial memory performance was evaluated in the radial-arm maze. Hippocampal sections were analyzed for cell death and mossy fiber sprouting at 1 or 60days after SE. Compared to SE group, HSE had increased SE latency, reduced number of rats with SRS, reduced mossy fiber sprouting at 60days, and reduced cell death in the hilus and the CA3 region 1 and 60days after SE. Additionally, HSE rats had better spatial memory performance than SE rats. Our findings indicated that short hypoxic preconditioning preceding SE promotes long-lasting protective effects on neuron survival and spatial memory. 2017-06-02T11:31:45Z 2017-06-02T11:31:45Z 2016-06 article https://repositorio.ufrn.br/jspui/handle/123456789/23366 10.1016/j.neuroscience.2016.06.047 eng Acesso Aberto application/pdf
institution Repositório Institucional
collection RI - UFRN
language eng
topic hypoxic preconditioning
memory deficit
mossy fiber sprouting
neuronal death
pilocarpine-induced status epilepticus
temporal lobe epilepsy
spellingShingle hypoxic preconditioning
memory deficit
mossy fiber sprouting
neuronal death
pilocarpine-induced status epilepticus
temporal lobe epilepsy
Do Val-da Silva, RA
Peixoto-Santos, JE
Scandiuzzi, RC
Balista, PA
Bassi, M
Glass, ML
Romcy-Pereira, Rodrigo Neves
Galvis-Alonso, OY
Leite, JP
Decreased neuron loss and memory dysfunction in pilocarpine-treated rats pre-exposed to hypoxia
description Preconditioning can induce a cascade of cellular events leading to neuroprotection against subsequent brain insults. In this study, we investigated the chronic effects of hypoxic preconditioning on spontaneous recurrent seizures (SRS), neuronal death, and spatial memory performance in rats subjected to pilocarpine (Pilo)-induced status epilepticus (SE). Rats underwent a short hypoxic episode (7% O2+93% N2; 30min on two consecutive days) preceding a 4-h SE (HSE group). Control groups were rats submitted to SE only (SE), rats subjected to hypoxia only (H) or normoxia-saline (C). Animals were monitored for the occurrence of SRS, and spatial memory performance was evaluated in the radial-arm maze. Hippocampal sections were analyzed for cell death and mossy fiber sprouting at 1 or 60days after SE. Compared to SE group, HSE had increased SE latency, reduced number of rats with SRS, reduced mossy fiber sprouting at 60days, and reduced cell death in the hilus and the CA3 region 1 and 60days after SE. Additionally, HSE rats had better spatial memory performance than SE rats. Our findings indicated that short hypoxic preconditioning preceding SE promotes long-lasting protective effects on neuron survival and spatial memory.
format article
author Do Val-da Silva, RA
Peixoto-Santos, JE
Scandiuzzi, RC
Balista, PA
Bassi, M
Glass, ML
Romcy-Pereira, Rodrigo Neves
Galvis-Alonso, OY
Leite, JP
author_facet Do Val-da Silva, RA
Peixoto-Santos, JE
Scandiuzzi, RC
Balista, PA
Bassi, M
Glass, ML
Romcy-Pereira, Rodrigo Neves
Galvis-Alonso, OY
Leite, JP
author_sort Do Val-da Silva, RA
title Decreased neuron loss and memory dysfunction in pilocarpine-treated rats pre-exposed to hypoxia
title_short Decreased neuron loss and memory dysfunction in pilocarpine-treated rats pre-exposed to hypoxia
title_full Decreased neuron loss and memory dysfunction in pilocarpine-treated rats pre-exposed to hypoxia
title_fullStr Decreased neuron loss and memory dysfunction in pilocarpine-treated rats pre-exposed to hypoxia
title_full_unstemmed Decreased neuron loss and memory dysfunction in pilocarpine-treated rats pre-exposed to hypoxia
title_sort decreased neuron loss and memory dysfunction in pilocarpine-treated rats pre-exposed to hypoxia
publishDate 2017
url https://repositorio.ufrn.br/jspui/handle/123456789/23366
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