Nicotine modulates the long-lasting storage of fear memory

Late post-training activation of the ventral tegmental area (VTA)–hippocampus dopaminergic loop controls the entry of information into long-term memory (LTM). Nicotinic acetylcholine receptors (nAChR) modulate VTA function, but their involvement in LTM storage is unknown. Using pharmacological and b...

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Principais autores: Lima, Ramón H., Radiske, Andressa, Köhler, Cristiano A., Gonzalez, Maria Carolina, Bevilaqua, Lia Rejane Müller, Rossato, Janine I., Medina, Jorge H., Cammarota, Martín Pablo
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Idioma:eng
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Assuntos:
hippocampus
ventral tegmental area
long-term memory
Nicotinic acetylcholine receptors
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/23337
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spelling ri-123456789-233372021-07-09T21:05:51Z Nicotine modulates the long-lasting storage of fear memory Lima, Ramón H. Radiske, Andressa Köhler, Cristiano A. Gonzalez, Maria Carolina Bevilaqua, Lia Rejane Müller Rossato, Janine I. Medina, Jorge H. Cammarota, Martín Pablo hippocampus ventral tegmental area long-term memory Nicotinic acetylcholine receptors Late post-training activation of the ventral tegmental area (VTA)–hippocampus dopaminergic loop controls the entry of information into long-term memory (LTM). Nicotinic acetylcholine receptors (nAChR) modulate VTA function, but their involvement in LTM storage is unknown. Using pharmacological and behavioral tools, we found that α7-nAChR-mediated cholinergic interactions between the pedunculopontine tegmental nucleus and the medial prefrontal cortex modulate the duration of fear-motivated memories, maybe by regulating the activation state of VTA–hippocampus dopamine connections. 2017-06-01T12:57:37Z 2017-06-01T12:57:37Z 2013 article https://repositorio.ufrn.br/jspui/handle/123456789/23337 10.1101/lm.029900.112 eng Acesso Aberto application/pdf
institution Repositório Institucional
collection RI - UFRN
language eng
topic hippocampus
ventral tegmental area
long-term memory
Nicotinic acetylcholine receptors
spellingShingle hippocampus
ventral tegmental area
long-term memory
Nicotinic acetylcholine receptors
Lima, Ramón H.
Radiske, Andressa
Köhler, Cristiano A.
Gonzalez, Maria Carolina
Bevilaqua, Lia Rejane Müller
Rossato, Janine I.
Medina, Jorge H.
Cammarota, Martín Pablo
Nicotine modulates the long-lasting storage of fear memory
description Late post-training activation of the ventral tegmental area (VTA)–hippocampus dopaminergic loop controls the entry of information into long-term memory (LTM). Nicotinic acetylcholine receptors (nAChR) modulate VTA function, but their involvement in LTM storage is unknown. Using pharmacological and behavioral tools, we found that α7-nAChR-mediated cholinergic interactions between the pedunculopontine tegmental nucleus and the medial prefrontal cortex modulate the duration of fear-motivated memories, maybe by regulating the activation state of VTA–hippocampus dopamine connections.
format article
author Lima, Ramón H.
Radiske, Andressa
Köhler, Cristiano A.
Gonzalez, Maria Carolina
Bevilaqua, Lia Rejane Müller
Rossato, Janine I.
Medina, Jorge H.
Cammarota, Martín Pablo
author_facet Lima, Ramón H.
Radiske, Andressa
Köhler, Cristiano A.
Gonzalez, Maria Carolina
Bevilaqua, Lia Rejane Müller
Rossato, Janine I.
Medina, Jorge H.
Cammarota, Martín Pablo
author_sort Lima, Ramón H.
title Nicotine modulates the long-lasting storage of fear memory
title_short Nicotine modulates the long-lasting storage of fear memory
title_full Nicotine modulates the long-lasting storage of fear memory
title_fullStr Nicotine modulates the long-lasting storage of fear memory
title_full_unstemmed Nicotine modulates the long-lasting storage of fear memory
title_sort nicotine modulates the long-lasting storage of fear memory
publishDate 2017
url https://repositorio.ufrn.br/jspui/handle/123456789/23337
work_keys_str_mv AT limaramonh nicotinemodulatesthelonglastingstorageoffearmemory
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AT kohlercristianoa nicotinemodulatesthelonglastingstorageoffearmemory
AT gonzalezmariacarolina nicotinemodulatesthelonglastingstorageoffearmemory
AT bevilaqualiarejanemuller nicotinemodulatesthelonglastingstorageoffearmemory
AT rossatojaninei nicotinemodulatesthelonglastingstorageoffearmemory
AT medinajorgeh nicotinemodulatesthelonglastingstorageoffearmemory
AT cammarotamartinpablo nicotinemodulatesthelonglastingstorageoffearmemory
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