Nicotine modulates the long-lasting storage of fear memory

Late post-training activation of the ventral tegmental area (VTA)–hippocampus dopaminergic loop controls the entry of information into long-term memory (LTM). Nicotinic acetylcholine receptors (nAChR) modulate VTA function, but their involvement in LTM storage is unknown. Using pharmacological and b...

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Detalhes bibliográficos
Principais autores: Lima, Ramón H., Radiske, Andressa, Köhler, Cristiano A., Gonzalez, Maria Carolina, Bevilaqua, Lia Rejane Müller, Rossato, Janine I., Medina, Jorge H., Cammarota, Martín Pablo
Formato: article
Idioma:eng
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Assuntos:
hippocampus
ventral tegmental area
long-term memory
Nicotinic acetylcholine receptors
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/23337
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Descrição
Resumo:Late post-training activation of the ventral tegmental area (VTA)–hippocampus dopaminergic loop controls the entry of information into long-term memory (LTM). Nicotinic acetylcholine receptors (nAChR) modulate VTA function, but their involvement in LTM storage is unknown. Using pharmacological and behavioral tools, we found that α7-nAChR-mediated cholinergic interactions between the pedunculopontine tegmental nucleus and the medial prefrontal cortex modulate the duration of fear-motivated memories, maybe by regulating the activation state of VTA–hippocampus dopamine connections.

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