The Human Cell Surfaceome of Breast Tumors
Cell surface proteins are ideal targets for cancer therapy and diagnosis. We have identified a set of more than 3700 genes that code for transmembrane proteins believed to be at human cell surface. Methods.We used a high-throuput qPCR system for the analysis of 573 cell surface protein-coding gene...
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ri-123456789-233362021-07-09T22:49:07Z The Human Cell Surfaceome of Breast Tumors Júlia Pinheiro Chagas da Cunha Pedro Alexandre Favoretto Galante Jorge Estefano Santana de Souza Martin Pieprzyk DirceMaria Carraro Lloyd J. Old Anamaria Aranha Camargo Souza, Sandro José de Human Cell Surfaceome Breast Tumors Cell surface proteins are ideal targets for cancer therapy and diagnosis. We have identified a set of more than 3700 genes that code for transmembrane proteins believed to be at human cell surface. Methods.We used a high-throuput qPCR system for the analysis of 573 cell surface protein-coding genes in 12 primary breast tumors, 8 breast cell lines, and 21 normal human tissues including breast. To better understand the role of these genes in breast tumors, we used a series of bioinformatics strategies to integrates different type, of the datasets, such as KEGG, protein-protein interaction databases, ONCOMINE, and data from, literature. Results. We found that at least 77 genes are overexpressed in breast primary tumors while at least 2 of them have also a restricted expression pattern in normal tissues. We found common signaling pathways that may be regulated in breast tumors through the overexpression of these cell surface protein-coding genes. Furthermore, a comparison was made between the genes found in this report and other genes associated with features clinically relevant for breast tumorigenesis. Conclusions.The expression profiling generated in this study, togetherwith an integrative bioinformatics analysis, allowed us to identify putative targets for breast tumors. 2017-06-01T12:57:32Z 2017-06-01T12:57:32Z 2013 article 2314-6133 https://repositorio.ufrn.br/jspui/handle/123456789/23336 eng Acesso Aberto application/pdf |
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| language |
eng |
| topic |
Human Cell Surfaceome Breast Tumors |
| spellingShingle |
Human Cell Surfaceome Breast Tumors Júlia Pinheiro Chagas da Cunha Pedro Alexandre Favoretto Galante Jorge Estefano Santana de Souza Martin Pieprzyk DirceMaria Carraro Lloyd J. Old Anamaria Aranha Camargo Souza, Sandro José de The Human Cell Surfaceome of Breast Tumors |
| description |
Cell surface proteins are ideal targets for cancer therapy and diagnosis. We have identified a set of more than 3700
genes that code for transmembrane proteins believed to be at human cell surface. Methods.We used a high-throuput qPCR system
for the analysis of 573 cell surface protein-coding genes in 12 primary breast tumors, 8 breast cell lines, and 21 normal human
tissues including breast. To better understand the role of these genes in breast tumors, we used a series of bioinformatics strategies
to integrates different type, of the datasets, such as KEGG, protein-protein interaction databases, ONCOMINE, and data from,
literature. Results. We found that at least 77 genes are overexpressed in breast primary tumors while at least 2 of them have also
a restricted expression pattern in normal tissues. We found common signaling pathways that may be regulated in breast tumors
through the overexpression of these cell surface protein-coding genes. Furthermore, a comparison was made between the genes
found in this report and other genes associated with features clinically relevant for breast tumorigenesis. Conclusions.The expression
profiling generated in this study, togetherwith an integrative bioinformatics analysis, allowed us to identify putative targets for breast
tumors. |
| format |
article |
| author |
Júlia Pinheiro Chagas da Cunha Pedro Alexandre Favoretto Galante Jorge Estefano Santana de Souza Martin Pieprzyk DirceMaria Carraro Lloyd J. Old Anamaria Aranha Camargo Souza, Sandro José de |
| author_facet |
Júlia Pinheiro Chagas da Cunha Pedro Alexandre Favoretto Galante Jorge Estefano Santana de Souza Martin Pieprzyk DirceMaria Carraro Lloyd J. Old Anamaria Aranha Camargo Souza, Sandro José de |
| author_sort |
Júlia Pinheiro Chagas da Cunha |
| title |
The Human Cell Surfaceome of Breast Tumors |
| title_short |
The Human Cell Surfaceome of Breast Tumors |
| title_full |
The Human Cell Surfaceome of Breast Tumors |
| title_fullStr |
The Human Cell Surfaceome of Breast Tumors |
| title_full_unstemmed |
The Human Cell Surfaceome of Breast Tumors |
| title_sort |
human cell surfaceome of breast tumors |
| publishDate |
2017 |
| url |
https://repositorio.ufrn.br/jspui/handle/123456789/23336 |
| work_keys_str_mv |
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