Functional integrity of the retrosplenial cortex is essential for rapid consolidation and recall of fear memory

Memory storage is a temporally graded process involving different phases and different structures in the mammalian brain. Cortical plasticity is essential to store stable memories, but little is known regarding its involvement in memory processing. Here we show that fear memory consolidation require...

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Principais autores: Katche, Cynthia, Dorman, Guido, Slipczuk, Leandro, Cammarota, Martín Pablo, Medina, Jorge H.
Formato: article
Idioma:eng
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Assuntos:
memory
cortical plasticity
post-training macromolecular synthesis
retrosplenial cortex
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/23321
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spelling ri-123456789-233212021-07-09T21:04:03Z Functional integrity of the retrosplenial cortex is essential for rapid consolidation and recall of fear memory Katche, Cynthia Dorman, Guido Slipczuk, Leandro Cammarota, Martín Pablo Medina, Jorge H. memory cortical plasticity post-training macromolecular synthesis retrosplenial cortex Memory storage is a temporally graded process involving different phases and different structures in the mammalian brain. Cortical plasticity is essential to store stable memories, but little is known regarding its involvement in memory processing. Here we show that fear memory consolidation requires early post-training macromolecular synthesis in the anterior part of the retrosplenial cortex (aRSC), and that reversible pharmacological inactivation of this cortical region impairs recall of recent as well as of remote memories. These results challenge the generally accepted idea that neocortical areas are slow encoding systems that participate in the retrieval of remote memories only. 2017-06-01T11:55:06Z 2017-06-01T11:55:06Z 2013 article https://repositorio.ufrn.br/jspui/handle/123456789/23321 10.1101/lm.030080.112 eng Acesso Aberto application/pdf
institution Repositório Institucional
collection RI - UFRN
language eng
topic memory
cortical plasticity
post-training macromolecular synthesis
retrosplenial cortex
spellingShingle memory
cortical plasticity
post-training macromolecular synthesis
retrosplenial cortex
Katche, Cynthia
Dorman, Guido
Slipczuk, Leandro
Cammarota, Martín Pablo
Medina, Jorge H.
Functional integrity of the retrosplenial cortex is essential for rapid consolidation and recall of fear memory
description Memory storage is a temporally graded process involving different phases and different structures in the mammalian brain. Cortical plasticity is essential to store stable memories, but little is known regarding its involvement in memory processing. Here we show that fear memory consolidation requires early post-training macromolecular synthesis in the anterior part of the retrosplenial cortex (aRSC), and that reversible pharmacological inactivation of this cortical region impairs recall of recent as well as of remote memories. These results challenge the generally accepted idea that neocortical areas are slow encoding systems that participate in the retrieval of remote memories only.
format article
author Katche, Cynthia
Dorman, Guido
Slipczuk, Leandro
Cammarota, Martín Pablo
Medina, Jorge H.
author_facet Katche, Cynthia
Dorman, Guido
Slipczuk, Leandro
Cammarota, Martín Pablo
Medina, Jorge H.
author_sort Katche, Cynthia
title Functional integrity of the retrosplenial cortex is essential for rapid consolidation and recall of fear memory
title_short Functional integrity of the retrosplenial cortex is essential for rapid consolidation and recall of fear memory
title_full Functional integrity of the retrosplenial cortex is essential for rapid consolidation and recall of fear memory
title_fullStr Functional integrity of the retrosplenial cortex is essential for rapid consolidation and recall of fear memory
title_full_unstemmed Functional integrity of the retrosplenial cortex is essential for rapid consolidation and recall of fear memory
title_sort functional integrity of the retrosplenial cortex is essential for rapid consolidation and recall of fear memory
publishDate 2017
url https://repositorio.ufrn.br/jspui/handle/123456789/23321
work_keys_str_mv AT katchecynthia functionalintegrityoftheretrosplenialcortexisessentialforrapidconsolidationandrecalloffearmemory
AT dormanguido functionalintegrityoftheretrosplenialcortexisessentialforrapidconsolidationandrecalloffearmemory
AT slipczukleandro functionalintegrityoftheretrosplenialcortexisessentialforrapidconsolidationandrecalloffearmemory
AT cammarotamartinpablo functionalintegrityoftheretrosplenialcortexisessentialforrapidconsolidationandrecalloffearmemory
AT medinajorgeh functionalintegrityoftheretrosplenialcortexisessentialforrapidconsolidationandrecalloffearmemory
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