Reactive Glia in the Injured Brain Acquire Stem Cell Properties in Response to Sonic Hedgehog

As a result of brain injury, astrocytes become activated and start to proliferate in the vicinity of the injury site. Recently, we had demonstrated that these reactive astrocytes, or glia, can form self-renewing and multipotent neurospheres in vitro. In the present study, we demonstrate that it...

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Principais autores: Sirko, Swetlana, Behrendt, Gwendolyn, Johansson, Pia Annette, Tripathi, Pratibha, Costa, Marcos Romualdo, Bek, Sarah, Heinrich, Christophe, Tiedt, Steffen, Colak, Dilek, Dichgans, Martin, Fischer, Isabel Rebekka, Plesnila, Nikolaus, Staufenbiel, Matthias, Haass, Christian, Snapyan, Marina, Saghatelyan, Armen, Li-Huei, Tsai, Fischer, André, Grobe, Kay, Dimou, Leda, Götz, Magdalena
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Idioma:eng
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Assuntos:
Reactive Glia
Brain Acquire
Stem Cell Properties
Sonic Hedgehog
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/23319
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spelling ri-123456789-233192017-11-04T22:17:18Z Reactive Glia in the Injured Brain Acquire Stem Cell Properties in Response to Sonic Hedgehog Sirko, Swetlana Behrendt, Gwendolyn Johansson, Pia Annette Tripathi, Pratibha Costa, Marcos Romualdo Bek, Sarah Heinrich, Christophe Tiedt, Steffen Colak, Dilek Dichgans, Martin Fischer, Isabel Rebekka Plesnila, Nikolaus Staufenbiel, Matthias Haass, Christian Snapyan, Marina Saghatelyan, Armen Li-Huei, Tsai Fischer, André Grobe, Kay Dimou, Leda Götz, Magdalena Reactive Glia Brain Acquire Stem Cell Properties Sonic Hedgehog As a result of brain injury, astrocytes become activated and start to proliferate in the vicinity of the injury site. Recently, we had demonstrated that these reactive astrocytes, or glia, can form self-renewing and multipotent neurospheres in vitro. In the present study, we demonstrate that it is only invasive injury, such as stab wounding or cerebral ischemia, and not noninvasive injury conditions, such as chronic amyloidosis or induced neuronal death, that can elicit this increase in plasticity. Furthermore, we find that Sonic hedgehog (SHH) is the signal that acts directly on the astrocytes and is necessary and sufficient to elicit the stem cell response both in vitro and in vivo. These findings provide a molecular basis for how cells with neural stem cell lineage emerge at sites of brain injury and imply that the high levels of SHH known to enter the brain from extraneural sources after invasive injury can trigger this response. 2017-06-01T11:54:52Z 2017-06-01T11:54:52Z 2013-04-04 article 1934-5909 https://repositorio.ufrn.br/jspui/handle/123456789/23319 eng Acesso Aberto application/pdf
institution Repositório Institucional
collection RI - UFRN
language eng
topic Reactive Glia
Brain Acquire
Stem Cell Properties
Sonic Hedgehog
spellingShingle Reactive Glia
Brain Acquire
Stem Cell Properties
Sonic Hedgehog
Sirko, Swetlana
Behrendt, Gwendolyn
Johansson, Pia Annette
Tripathi, Pratibha
Costa, Marcos Romualdo
Bek, Sarah
Heinrich, Christophe
Tiedt, Steffen
Colak, Dilek
Dichgans, Martin
Fischer, Isabel Rebekka
Plesnila, Nikolaus
Staufenbiel, Matthias
Haass, Christian
Snapyan, Marina
Saghatelyan, Armen
Li-Huei, Tsai
Fischer, André
Grobe, Kay
Dimou, Leda
Götz, Magdalena
Reactive Glia in the Injured Brain Acquire Stem Cell Properties in Response to Sonic Hedgehog
description As a result of brain injury, astrocytes become activated and start to proliferate in the vicinity of the injury site. Recently, we had demonstrated that these reactive astrocytes, or glia, can form self-renewing and multipotent neurospheres in vitro. In the present study, we demonstrate that it is only invasive injury, such as stab wounding or cerebral ischemia, and not noninvasive injury conditions, such as chronic amyloidosis or induced neuronal death, that can elicit this increase in plasticity. Furthermore, we find that Sonic hedgehog (SHH) is the signal that acts directly on the astrocytes and is necessary and sufficient to elicit the stem cell response both in vitro and in vivo. These findings provide a molecular basis for how cells with neural stem cell lineage emerge at sites of brain injury and imply that the high levels of SHH known to enter the brain from extraneural sources after invasive injury can trigger this response.
format article
author Sirko, Swetlana
Behrendt, Gwendolyn
Johansson, Pia Annette
Tripathi, Pratibha
Costa, Marcos Romualdo
Bek, Sarah
Heinrich, Christophe
Tiedt, Steffen
Colak, Dilek
Dichgans, Martin
Fischer, Isabel Rebekka
Plesnila, Nikolaus
Staufenbiel, Matthias
Haass, Christian
Snapyan, Marina
Saghatelyan, Armen
Li-Huei, Tsai
Fischer, André
Grobe, Kay
Dimou, Leda
Götz, Magdalena
author_facet Sirko, Swetlana
Behrendt, Gwendolyn
Johansson, Pia Annette
Tripathi, Pratibha
Costa, Marcos Romualdo
Bek, Sarah
Heinrich, Christophe
Tiedt, Steffen
Colak, Dilek
Dichgans, Martin
Fischer, Isabel Rebekka
Plesnila, Nikolaus
Staufenbiel, Matthias
Haass, Christian
Snapyan, Marina
Saghatelyan, Armen
Li-Huei, Tsai
Fischer, André
Grobe, Kay
Dimou, Leda
Götz, Magdalena
author_sort Sirko, Swetlana
title Reactive Glia in the Injured Brain Acquire Stem Cell Properties in Response to Sonic Hedgehog
title_short Reactive Glia in the Injured Brain Acquire Stem Cell Properties in Response to Sonic Hedgehog
title_full Reactive Glia in the Injured Brain Acquire Stem Cell Properties in Response to Sonic Hedgehog
title_fullStr Reactive Glia in the Injured Brain Acquire Stem Cell Properties in Response to Sonic Hedgehog
title_full_unstemmed Reactive Glia in the Injured Brain Acquire Stem Cell Properties in Response to Sonic Hedgehog
title_sort reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog
publishDate 2017
url https://repositorio.ufrn.br/jspui/handle/123456789/23319
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