Reactive Glia in the Injured Brain Acquire Stem Cell Properties in Response to Sonic Hedgehog
As a result of brain injury, astrocytes become activated and start to proliferate in the vicinity of the injury site. Recently, we had demonstrated that these reactive astrocytes, or glia, can form self-renewing and multipotent neurospheres in vitro. In the present study, we demonstrate that it...
Na minha lista:
| Principais autores: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Idioma: | eng |
| Publicado em: |
|
| Assuntos: | |
| Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/23319 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|
| Resumo: | As a result of brain injury, astrocytes become activated
and start to proliferate in the vicinity of the
injury site. Recently, we had demonstrated that these
reactive astrocytes, or glia, can form self-renewing
and multipotent neurospheres in vitro. In the present
study, we demonstrate that it is only invasive injury,
such as stab wounding or cerebral ischemia, and
not noninvasive injury conditions, such as chronic
amyloidosis or induced neuronal death, that can elicit
this increase in plasticity. Furthermore, we find that
Sonic hedgehog (SHH) is the signal that acts directly
on the astrocytes and is necessary and sufficient
to elicit the stem cell response both in vitro and
in vivo. These findings provide a molecular basis for
how cells with neural stem cell lineage emerge at
sites of brain injury and imply that the high levels of
SHH known to enter the brain from extraneural sources
after invasive injury can trigger this response. |
|---|