Social isolation disrupts hippocampal neurogenesis in young non-human primates

Social relationships are crucial for the development and maintenance of normal behavior in non-human primates. Animals that are raised in isolation develop abnormal patterns of behavior that persist even when they are later reunited with their parents. In rodents, social isolation is a stressful eve...

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Principais autores:	Cinini, Simone M., Barnabe, Gabriela F., Galvão-Coelho, Nicole, Medeiros, Magda A. de, Perez-Mendes, Patrícia, Sousa, Maria Bernardete Cordeiro de, Covolan, Luciene, Mello, Luiz E.
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Idioma:	eng
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Assuntos:	anxiety hippocampal neurogenesis isolation stress social isolation young marmosets
Endereço do item:	https://repositorio.ufrn.br/jspui/handle/123456789/23276
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spelling	ri-123456789-232762021-07-09T20:52:38Z Social isolation disrupts hippocampal neurogenesis in young non-human primates Cinini, Simone M. Barnabe, Gabriela F. Galvão-Coelho, Nicole Medeiros, Magda A. de Perez-Mendes, Patrícia Sousa, Maria Bernardete Cordeiro de Covolan, Luciene Mello, Luiz E. anxiety hippocampal neurogenesis isolation stress social isolation young marmosets Social relationships are crucial for the development and maintenance of normal behavior in non-human primates. Animals that are raised in isolation develop abnormal patterns of behavior that persist even when they are later reunited with their parents. In rodents, social isolation is a stressful event and is associated with a decrease in hippocampal neurogenesis but considerably less is known about the effects of social isolation in non-human primates during the transition from adolescence to adulthood. To investigate how social isolation affects young marmosets, these were isolated from other members of the colony for 1 or 3 weeks and evaluated for alterations in their behavior and hippocampal cell proliferation. We found that anxiety-related behaviors like scent-marking and locomotor activity increased after social isolation when compared to baseline levels. In agreement, grooming-an indicative of attenuation of tension-was reduced among isolated marmosets. These results were consistent with increased cortisol levels after 1 and 3 weeks of isolation. After social isolation (1 or 3 weeks), reduced proliferation of neural cells in the subgranular zone of dentate granule cell layer was identified and a smaller proportion of BrdU-positive cells underwent neuronal fate (doublecortin labeling). Our data is consistent with the notion that social deprivation during the transition from adolescence to adulthood leads to stress and produces anxiety-like behaviors that in turn might affect neurogenesis and contribute to the deleterious consequences of prolonged stressful conditions. 2017-05-31T13:34:08Z 2017-05-31T13:34:08Z 2014-03 article https://repositorio.ufrn.br/jspui/handle/123456789/23276 10.3389/fnins.2014.00045 eng Acesso Aberto application/pdf
institution	Repositório Institucional
collection	RI - UFRN
language	eng
topic	anxiety hippocampal neurogenesis isolation stress social isolation young marmosets
spellingShingle	anxiety hippocampal neurogenesis isolation stress social isolation young marmosets Cinini, Simone M. Barnabe, Gabriela F. Galvão-Coelho, Nicole Medeiros, Magda A. de Perez-Mendes, Patrícia Sousa, Maria Bernardete Cordeiro de Covolan, Luciene Mello, Luiz E. Social isolation disrupts hippocampal neurogenesis in young non-human primates
description	Social relationships are crucial for the development and maintenance of normal behavior in non-human primates. Animals that are raised in isolation develop abnormal patterns of behavior that persist even when they are later reunited with their parents. In rodents, social isolation is a stressful event and is associated with a decrease in hippocampal neurogenesis but considerably less is known about the effects of social isolation in non-human primates during the transition from adolescence to adulthood. To investigate how social isolation affects young marmosets, these were isolated from other members of the colony for 1 or 3 weeks and evaluated for alterations in their behavior and hippocampal cell proliferation. We found that anxiety-related behaviors like scent-marking and locomotor activity increased after social isolation when compared to baseline levels. In agreement, grooming-an indicative of attenuation of tension-was reduced among isolated marmosets. These results were consistent with increased cortisol levels after 1 and 3 weeks of isolation. After social isolation (1 or 3 weeks), reduced proliferation of neural cells in the subgranular zone of dentate granule cell layer was identified and a smaller proportion of BrdU-positive cells underwent neuronal fate (doublecortin labeling). Our data is consistent with the notion that social deprivation during the transition from adolescence to adulthood leads to stress and produces anxiety-like behaviors that in turn might affect neurogenesis and contribute to the deleterious consequences of prolonged stressful conditions.
format	article
author	Cinini, Simone M. Barnabe, Gabriela F. Galvão-Coelho, Nicole Medeiros, Magda A. de Perez-Mendes, Patrícia Sousa, Maria Bernardete Cordeiro de Covolan, Luciene Mello, Luiz E.
author_facet	Cinini, Simone M. Barnabe, Gabriela F. Galvão-Coelho, Nicole Medeiros, Magda A. de Perez-Mendes, Patrícia Sousa, Maria Bernardete Cordeiro de Covolan, Luciene Mello, Luiz E.
author_sort	Cinini, Simone M.
title	Social isolation disrupts hippocampal neurogenesis in young non-human primates
title_short	Social isolation disrupts hippocampal neurogenesis in young non-human primates
title_full	Social isolation disrupts hippocampal neurogenesis in young non-human primates
title_fullStr	Social isolation disrupts hippocampal neurogenesis in young non-human primates
title_full_unstemmed	Social isolation disrupts hippocampal neurogenesis in young non-human primates
title_sort	social isolation disrupts hippocampal neurogenesis in young non-human primates
publishDate	2017
url	https://repositorio.ufrn.br/jspui/handle/123456789/23276
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Social isolation disrupts hippocampal neurogenesis in young non-human primates

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