Noradrenergic Control of Gene Expression and Long- Term Neuronal Adaptation Evoked by Learned Vocalizations in Songbirds

Norepinephrine (NE) is thought to play important roles in the consolidation and retrieval of long-term memories, but its role in the processing and memorization of complex acoustic signals used for vocal communication has yet to be determined. We have used a combination of gene expression analysis...

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Principais autores:	Velho, Tarciso André Ferreira, Lu, Kai, Ribeiro, Sidarta Tollendal Gomes, Pinaud, Raphael, Vicario, David, Mello, Claudio V.
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Idioma:	eng
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Assuntos:	Noradrenergic Control Gene Expression Vocalizations Songbirds
Endereço do item:	https://repositorio.ufrn.br/jspui/handle/123456789/23263
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spelling	ri-123456789-232632021-07-12T18:42:40Z Noradrenergic Control of Gene Expression and Long- Term Neuronal Adaptation Evoked by Learned Vocalizations in Songbirds Velho, Tarciso André Ferreira Lu, Kai Ribeiro, Sidarta Tollendal Gomes Pinaud, Raphael Vicario, David Mello, Claudio V. Noradrenergic Control Gene Expression Vocalizations Songbirds Norepinephrine (NE) is thought to play important roles in the consolidation and retrieval of long-term memories, but its role in the processing and memorization of complex acoustic signals used for vocal communication has yet to be determined. We have used a combination of gene expression analysis, electrophysiological recordings and pharmacological manipulations in zebra finches to examine the role of noradrenergic transmission in the brain’s response to birdsong, a learned vocal behavior that shares important features with human speech. We show that noradrenergic transmission is required for both the expression of activity-dependent genes and the long-term maintenance of stimulus-specific electrophysiological adaptation that are induced in central auditory neurons by stimulation with birdsong. Specifically, we show that the caudomedial nidopallium (NCM), an area directly involved in the auditory processing and memorization of birdsong, receives strong noradrenergic innervation. Song-responsive neurons in this area express a-adrenergic receptors and are in close proximity to noradrenergic terminals. We further show that local a-adrenergic antagonism interferes with song-induced gene expression, without affecting spontaneous or evoked electrophysiological activity, thus dissociating the molecular and electrophysiological responses to song. Moreover, a-adrenergic antagonism disrupts the maintenance but not the acquisition of the adapted physiological state. We suggest that the noradrenergic system regulates long-term changes in song-responsive neurons by modulating the gene expression response that is associated with the electrophysiological activation triggered by song. We also suggest that this mechanism may be an important contributor to long-term auditory memories of learned vocalizations. 2017-05-31T12:40:09Z 2017-05-31T12:40:09Z 2012-05-04 article 1932-6203 https://repositorio.ufrn.br/jspui/handle/123456789/23263 eng Acesso Aberto application/pdf
institution	Repositório Institucional
collection	RI - UFRN
language	eng
topic	Noradrenergic Control Gene Expression Vocalizations Songbirds
spellingShingle	Noradrenergic Control Gene Expression Vocalizations Songbirds Velho, Tarciso André Ferreira Lu, Kai Ribeiro, Sidarta Tollendal Gomes Pinaud, Raphael Vicario, David Mello, Claudio V. Noradrenergic Control of Gene Expression and Long- Term Neuronal Adaptation Evoked by Learned Vocalizations in Songbirds
description	Norepinephrine (NE) is thought to play important roles in the consolidation and retrieval of long-term memories, but its role in the processing and memorization of complex acoustic signals used for vocal communication has yet to be determined. We have used a combination of gene expression analysis, electrophysiological recordings and pharmacological manipulations in zebra finches to examine the role of noradrenergic transmission in the brain’s response to birdsong, a learned vocal behavior that shares important features with human speech. We show that noradrenergic transmission is required for both the expression of activity-dependent genes and the long-term maintenance of stimulus-specific electrophysiological adaptation that are induced in central auditory neurons by stimulation with birdsong. Specifically, we show that the caudomedial nidopallium (NCM), an area directly involved in the auditory processing and memorization of birdsong, receives strong noradrenergic innervation. Song-responsive neurons in this area express a-adrenergic receptors and are in close proximity to noradrenergic terminals. We further show that local a-adrenergic antagonism interferes with song-induced gene expression, without affecting spontaneous or evoked electrophysiological activity, thus dissociating the molecular and electrophysiological responses to song. Moreover, a-adrenergic antagonism disrupts the maintenance but not the acquisition of the adapted physiological state. We suggest that the noradrenergic system regulates long-term changes in song-responsive neurons by modulating the gene expression response that is associated with the electrophysiological activation triggered by song. We also suggest that this mechanism may be an important contributor to long-term auditory memories of learned vocalizations.
format	article
author	Velho, Tarciso André Ferreira Lu, Kai Ribeiro, Sidarta Tollendal Gomes Pinaud, Raphael Vicario, David Mello, Claudio V.
author_facet	Velho, Tarciso André Ferreira Lu, Kai Ribeiro, Sidarta Tollendal Gomes Pinaud, Raphael Vicario, David Mello, Claudio V.
author_sort	Velho, Tarciso André Ferreira
title	Noradrenergic Control of Gene Expression and Long- Term Neuronal Adaptation Evoked by Learned Vocalizations in Songbirds
title_short	Noradrenergic Control of Gene Expression and Long- Term Neuronal Adaptation Evoked by Learned Vocalizations in Songbirds
title_full	Noradrenergic Control of Gene Expression and Long- Term Neuronal Adaptation Evoked by Learned Vocalizations in Songbirds
title_fullStr	Noradrenergic Control of Gene Expression and Long- Term Neuronal Adaptation Evoked by Learned Vocalizations in Songbirds
title_full_unstemmed	Noradrenergic Control of Gene Expression and Long- Term Neuronal Adaptation Evoked by Learned Vocalizations in Songbirds
title_sort	noradrenergic control of gene expression and long- term neuronal adaptation evoked by learned vocalizations in songbirds
publishDate	2017
url	https://repositorio.ufrn.br/jspui/handle/123456789/23263
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_version_	1773959291336654848

Noradrenergic Control of Gene Expression and Long- Term Neuronal Adaptation Evoked by Learned Vocalizations in Songbirds

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