State-dependent effect of dopamine D1/D5 receptors inactivation on memory destabilization and reconsolidation

Object recognition memories (ORM) can incorporate new information upon reactivation. This update initially involves destabilization of the original memory, which is followed by restabilization of the upgraded engram through a reconsolidation process that requires gene expression and protein synthesi...

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Principais autores:	Rossato, Janine I., Köhler, Cristiano A., Radiske, Andressa, Lima, Ramón H., Bevilaqua, Lia Rejane Müller, Cammarota, Martín Pablo
Formato:	article
Idioma:	eng
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Assuntos:	Gene expression Hippocampus Object recognition memory Protein synthesis Retrieval
Endereço do item:	https://repositorio.ufrn.br/jspui/handle/123456789/23194
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spelling	ri-123456789-231942021-07-09T21:08:00Z State-dependent effect of dopamine D1/D5 receptors inactivation on memory destabilization and reconsolidation Rossato, Janine I. Köhler, Cristiano A. Radiske, Andressa Lima, Ramón H. Bevilaqua, Lia Rejane Müller Cammarota, Martín Pablo Gene expression Hippocampus Object recognition memory Protein synthesis Retrieval Object recognition memories (ORM) can incorporate new information upon reactivation. This update initially involves destabilization of the original memory, which is followed by restabilization of the upgraded engram through a reconsolidation process that requires gene expression and protein synthesis in the hippocampus. We found that when given in dorsal CA1 either immediately after training or 15 min before ORM reactivation in the presence of a novel object, the dopamine D1/D5 receptor antagonist SCH23390 did not affect ORM consolidation, expression or retention but impeded the amnesia caused by the post-retrieval administration of the mRNA synthesis inhibitor α-amanitin or the protein synthesis blocker anisomycin. This anti-amnesic effect was not observed when SCH23390 was given immediately after training and again 15 min before memory reactivation. Our results demonstrate that hippocampal D1/D5 receptors are not needed for formation, retrieval or post-retrieval restabilization of the ORM trace but are essential for its destabilization when reactivation occurs together with the incorporation of new information into the original memory. Importantly, they also suggest that reenactment of the animal's post-learning neurochemical milieu at the moment of memory reactivation can be a boundary condition for reconsolidation. 2017-05-29T18:58:14Z 2017-05-29T18:58:14Z 2015 article https://repositorio.ufrn.br/jspui/handle/123456789/23194 10.1016/j.bbr.2014.09.009 eng Acesso Aberto application/pdf
institution	Repositório Institucional
collection	RI - UFRN
language	eng
topic	Gene expression Hippocampus Object recognition memory Protein synthesis Retrieval
spellingShingle	Gene expression Hippocampus Object recognition memory Protein synthesis Retrieval Rossato, Janine I. Köhler, Cristiano A. Radiske, Andressa Lima, Ramón H. Bevilaqua, Lia Rejane Müller Cammarota, Martín Pablo State-dependent effect of dopamine D1/D5 receptors inactivation on memory destabilization and reconsolidation
description	Object recognition memories (ORM) can incorporate new information upon reactivation. This update initially involves destabilization of the original memory, which is followed by restabilization of the upgraded engram through a reconsolidation process that requires gene expression and protein synthesis in the hippocampus. We found that when given in dorsal CA1 either immediately after training or 15 min before ORM reactivation in the presence of a novel object, the dopamine D1/D5 receptor antagonist SCH23390 did not affect ORM consolidation, expression or retention but impeded the amnesia caused by the post-retrieval administration of the mRNA synthesis inhibitor α-amanitin or the protein synthesis blocker anisomycin. This anti-amnesic effect was not observed when SCH23390 was given immediately after training and again 15 min before memory reactivation. Our results demonstrate that hippocampal D1/D5 receptors are not needed for formation, retrieval or post-retrieval restabilization of the ORM trace but are essential for its destabilization when reactivation occurs together with the incorporation of new information into the original memory. Importantly, they also suggest that reenactment of the animal's post-learning neurochemical milieu at the moment of memory reactivation can be a boundary condition for reconsolidation.
format	article
author	Rossato, Janine I. Köhler, Cristiano A. Radiske, Andressa Lima, Ramón H. Bevilaqua, Lia Rejane Müller Cammarota, Martín Pablo
author_facet	Rossato, Janine I. Köhler, Cristiano A. Radiske, Andressa Lima, Ramón H. Bevilaqua, Lia Rejane Müller Cammarota, Martín Pablo
author_sort	Rossato, Janine I.
title	State-dependent effect of dopamine D1/D5 receptors inactivation on memory destabilization and reconsolidation
title_short	State-dependent effect of dopamine D1/D5 receptors inactivation on memory destabilization and reconsolidation
title_full	State-dependent effect of dopamine D1/D5 receptors inactivation on memory destabilization and reconsolidation
title_fullStr	State-dependent effect of dopamine D1/D5 receptors inactivation on memory destabilization and reconsolidation
title_full_unstemmed	State-dependent effect of dopamine D1/D5 receptors inactivation on memory destabilization and reconsolidation
title_sort	state-dependent effect of dopamine d1/d5 receptors inactivation on memory destabilization and reconsolidation
publishDate	2017
url	https://repositorio.ufrn.br/jspui/handle/123456789/23194
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State-dependent effect of dopamine D1/D5 receptors inactivation on memory destabilization and reconsolidation

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