Novel markers for OLM interneurons in the hippocampus

Oriens-lacunosum moleculare (OLM) cells are a major subclass of hippocampal interneurons involved in controlling synaptic plasticity in Shaffer collateral synapses (Leão et al., 2012) and electrogenesis in pyramidal cell (PC) dendrites (Lovett-Barron et al., 2012). Their firing phase is locked with...

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Principais autores: Mikulovic, Sanja, Restrepo, C. Ernesto, Hilscher, Markus M., Kullander, Klas, Leão, Richardson Naves
Formato: article
Idioma:eng
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Assuntos:
interneuron
Oriens-lacunosum moleculare
somatostatin
hippocampus
Chrna2
Endereço do item:https://repositorio.ufrn.br/jspui/handle/123456789/23188
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spelling ri-123456789-231882021-07-09T21:21:19Z Novel markers for OLM interneurons in the hippocampus Mikulovic, Sanja Restrepo, C. Ernesto Hilscher, Markus M. Kullander, Klas Leão, Richardson Naves interneuron Oriens-lacunosum moleculare somatostatin hippocampus Chrna2 Oriens-lacunosum moleculare (OLM) cells are a major subclass of hippocampal interneurons involved in controlling synaptic plasticity in Shaffer collateral synapses (Leão et al., 2012) and electrogenesis in pyramidal cell (PC) dendrites (Lovett-Barron et al., 2012). Their firing phase is locked with theta oscillations, which imply a role for these cells in theta rhythmogenesis (Klausberger and Somogyi, 2008; Forro et al., 2015). OLM interneurons also appear to be key in the pathophysiology of epilepsy (Dugladze et al., 2007) and is the most vulnerable interneuron population in models of epilepsy (Dinocourt et al., 2003). Somatostatin has been frequently used as a molecular marker for identification of OLM cells (Forro et al., 2015). Two recent studies suggest that the OLM cell population is heterogeneous. First, the expression of cholinergic receptor, nicotinic, alpha polypeptide 2 (Chrna2) seems to be restricted to OLM interneurons neurons of CA1 (Leão et al., 2012). Second, a subset of OLM interneurons that expresses the 5HT3a receptor is derived from the caudal ganglionic eminence and do not entrain to gamma oscillations. In contrast, OLM interneurons derived from the medial ganglionic eminence partially phase lock to in vitro gamma oscillations and do not express 5HT3a receptors (Chittajallu et al., 2013). Further, other dendritic targeting interneurons in the hippocampus also express somatostatin (Lovett-Barron et al., 2014). Hence, functional studies of OLM cell in hippocampal function have been targeting a relatively heterogenous cell population. 2017-05-29T17:35:56Z 2017-05-29T17:35:56Z 2015-06-02 article https://repositorio.ufrn.br/jspui/handle/123456789/23188 10.3389/fncel.2015.00201 eng Acesso Aberto application/pdf
institution Repositório Institucional
collection RI - UFRN
language eng
topic interneuron
Oriens-lacunosum moleculare
somatostatin
hippocampus
Chrna2
spellingShingle interneuron
Oriens-lacunosum moleculare
somatostatin
hippocampus
Chrna2
Mikulovic, Sanja
Restrepo, C. Ernesto
Hilscher, Markus M.
Kullander, Klas
Leão, Richardson Naves
Novel markers for OLM interneurons in the hippocampus
description Oriens-lacunosum moleculare (OLM) cells are a major subclass of hippocampal interneurons involved in controlling synaptic plasticity in Shaffer collateral synapses (Leão et al., 2012) and electrogenesis in pyramidal cell (PC) dendrites (Lovett-Barron et al., 2012). Their firing phase is locked with theta oscillations, which imply a role for these cells in theta rhythmogenesis (Klausberger and Somogyi, 2008; Forro et al., 2015). OLM interneurons also appear to be key in the pathophysiology of epilepsy (Dugladze et al., 2007) and is the most vulnerable interneuron population in models of epilepsy (Dinocourt et al., 2003). Somatostatin has been frequently used as a molecular marker for identification of OLM cells (Forro et al., 2015). Two recent studies suggest that the OLM cell population is heterogeneous. First, the expression of cholinergic receptor, nicotinic, alpha polypeptide 2 (Chrna2) seems to be restricted to OLM interneurons neurons of CA1 (Leão et al., 2012). Second, a subset of OLM interneurons that expresses the 5HT3a receptor is derived from the caudal ganglionic eminence and do not entrain to gamma oscillations. In contrast, OLM interneurons derived from the medial ganglionic eminence partially phase lock to in vitro gamma oscillations and do not express 5HT3a receptors (Chittajallu et al., 2013). Further, other dendritic targeting interneurons in the hippocampus also express somatostatin (Lovett-Barron et al., 2014). Hence, functional studies of OLM cell in hippocampal function have been targeting a relatively heterogenous cell population.
format article
author Mikulovic, Sanja
Restrepo, C. Ernesto
Hilscher, Markus M.
Kullander, Klas
Leão, Richardson Naves
author_facet Mikulovic, Sanja
Restrepo, C. Ernesto
Hilscher, Markus M.
Kullander, Klas
Leão, Richardson Naves
author_sort Mikulovic, Sanja
title Novel markers for OLM interneurons in the hippocampus
title_short Novel markers for OLM interneurons in the hippocampus
title_full Novel markers for OLM interneurons in the hippocampus
title_fullStr Novel markers for OLM interneurons in the hippocampus
title_full_unstemmed Novel markers for OLM interneurons in the hippocampus
title_sort novel markers for olm interneurons in the hippocampus
publishDate 2017
url https://repositorio.ufrn.br/jspui/handle/123456789/23188
work_keys_str_mv AT mikulovicsanja novelmarkersforolminterneuronsinthehippocampus
AT restrepocernesto novelmarkersforolminterneuronsinthehippocampus
AT hilschermarkusm novelmarkersforolminterneuronsinthehippocampus
AT kullanderklas novelmarkersforolminterneuronsinthehippocampus
AT leaorichardsonnaves novelmarkersforolminterneuronsinthehippocampus
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