Context Matters: The Illusive Simplicity of Macaque V1 Receptive Fields

Even in V1, where neurons have well characterized classical receptive fields (CRFs), it has been difficult to deduce which features of natural scenes stimuli they actually respond to. Forward models based upon CRF stimuli have had limited success in predicting the response of V1 neurons to natural...

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Principais autores:	Haslinger, Robert, Lima, Bruss, Singer, Wolf, Brown, Emery N., Maciel, Sergio Tulio Neuenschwander
Formato:	article
Idioma:	eng
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Assuntos:	Upon CRF V1 neurons Local field potential
Endereço do item:	https://repositorio.ufrn.br/jspui/handle/123456789/23177
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id	ri-123456789-23177
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spelling	ri-123456789-231772021-07-09T23:03:02Z Context Matters: The Illusive Simplicity of Macaque V1 Receptive Fields Haslinger, Robert Haslinger, Robert Lima, Bruss Singer, Wolf Brown, Emery N. Maciel, Sergio Tulio Neuenschwander Upon CRF V1 neurons Local field potential Even in V1, where neurons have well characterized classical receptive fields (CRFs), it has been difficult to deduce which features of natural scenes stimuli they actually respond to. Forward models based upon CRF stimuli have had limited success in predicting the response of V1 neurons to natural scenes. As natural scenes exhibit complex spatial and temporal correlations, this could be due to surround effects that modulate the sensitivity of the CRF. Here, instead of attempting a forward model, we quantify the importance of the natural scenes surround for awake macaque monkeys by modeling it non-parametrically. We also quantify the influence of two forms of trial to trial variability. The first is related to the neuron’s own spike history. The second is related to ongoing mean field population activity reflected by the local field potential (LFP). We find that the surround produces strong temporal modulations in the firing rate that can be both suppressive and facilitative. Further, the LFP is found to induce a precise timing in spikes, which tend to be temporally localized on sharp LFP transients in the gamma frequency range. Using the pseudo R2 as a measure of model fit, we find that during natural scene viewing the CRF dominates, accounting for 60% of the fit, but that taken collectively the surround, spike history and LFP are almost as important, accounting for 40%. However, overall only a small proportion of V1 spiking statistics could be explained (R2,5%), even when the full stimulus, spike history and LFP were taken into account. This suggests that under natural scene conditions, the dominant influence on V1 neurons is not the stimulus, nor the mean field dynamics of the LFP, but the complex, incoherent dynamics of the network in which neurons are embedded. 2017-05-29T14:11:56Z 2017-05-29T14:11:56Z 2012-07-03 article 1932-6203 https://repositorio.ufrn.br/jspui/handle/123456789/23177 eng Acesso Aberto application/pdf
institution	Repositório Institucional
collection	RI - UFRN
language	eng
topic	Upon CRF V1 neurons Local field potential
spellingShingle	Upon CRF V1 neurons Local field potential Haslinger, Robert Haslinger, Robert Lima, Bruss Singer, Wolf Brown, Emery N. Maciel, Sergio Tulio Neuenschwander Context Matters: The Illusive Simplicity of Macaque V1 Receptive Fields
description	Even in V1, where neurons have well characterized classical receptive fields (CRFs), it has been difficult to deduce which features of natural scenes stimuli they actually respond to. Forward models based upon CRF stimuli have had limited success in predicting the response of V1 neurons to natural scenes. As natural scenes exhibit complex spatial and temporal correlations, this could be due to surround effects that modulate the sensitivity of the CRF. Here, instead of attempting a forward model, we quantify the importance of the natural scenes surround for awake macaque monkeys by modeling it non-parametrically. We also quantify the influence of two forms of trial to trial variability. The first is related to the neuron’s own spike history. The second is related to ongoing mean field population activity reflected by the local field potential (LFP). We find that the surround produces strong temporal modulations in the firing rate that can be both suppressive and facilitative. Further, the LFP is found to induce a precise timing in spikes, which tend to be temporally localized on sharp LFP transients in the gamma frequency range. Using the pseudo R2 as a measure of model fit, we find that during natural scene viewing the CRF dominates, accounting for 60% of the fit, but that taken collectively the surround, spike history and LFP are almost as important, accounting for 40%. However, overall only a small proportion of V1 spiking statistics could be explained (R2,5%), even when the full stimulus, spike history and LFP were taken into account. This suggests that under natural scene conditions, the dominant influence on V1 neurons is not the stimulus, nor the mean field dynamics of the LFP, but the complex, incoherent dynamics of the network in which neurons are embedded.
format	article
author	Haslinger, Robert Haslinger, Robert Lima, Bruss Singer, Wolf Brown, Emery N. Maciel, Sergio Tulio Neuenschwander
author_facet	Haslinger, Robert Haslinger, Robert Lima, Bruss Singer, Wolf Brown, Emery N. Maciel, Sergio Tulio Neuenschwander
author_sort	Haslinger, Robert
title	Context Matters: The Illusive Simplicity of Macaque V1 Receptive Fields
title_short	Context Matters: The Illusive Simplicity of Macaque V1 Receptive Fields
title_full	Context Matters: The Illusive Simplicity of Macaque V1 Receptive Fields
title_fullStr	Context Matters: The Illusive Simplicity of Macaque V1 Receptive Fields
title_full_unstemmed	Context Matters: The Illusive Simplicity of Macaque V1 Receptive Fields
title_sort	context matters: the illusive simplicity of macaque v1 receptive fields
publishDate	2017
url	https://repositorio.ufrn.br/jspui/handle/123456789/23177
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Context Matters: The Illusive Simplicity of Macaque V1 Receptive Fields

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