Assessing Cerebrovascular Reactivity in Carotid Steno-Occlusive Disease UsingMRI BOLD and ASL Techniques
Impaired cerebrovascular reactivity (CVR), a predictive factor of imminent stroke, has been shown to be associated with carotid steno-occlusive disease. Magnetic resonance imaging (MRI) techniques, such as blood oxygenation level-dependent (BOLD) and arterial spin labeling (ASL), have emerged as p...
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ri-123456789-231732021-07-08T18:39:57Z Assessing Cerebrovascular Reactivity in Carotid Steno-Occlusive Disease UsingMRI BOLD and ASL Techniques Leoni, Renata F. Mazzetto-Betti, Kelley C. Silva, Afonso C. Santos, Antonio C. dos Araújo, Dráulio Barros de Leite, João P. Pontes-Neto, Octavio M. Carotid Steno-Occlusive Cerebrovascular Reactivity MRI BOLD ASL Impaired cerebrovascular reactivity (CVR), a predictive factor of imminent stroke, has been shown to be associated with carotid steno-occlusive disease. Magnetic resonance imaging (MRI) techniques, such as blood oxygenation level-dependent (BOLD) and arterial spin labeling (ASL), have emerged as promising noninvasive tools to evaluate altered CVR with whole-brain coverage, when combined with a vasoactive stimulus, such as respiratory task or injection of acetazolamide. Under normal cerebrovascular conditions, CVR has been shown to be globally and homogenously distributed between hemispheres, but with differences among cerebral regions. Such differences can be explained by anatomical specificities and different biochemical mechanisms responsible for vascular regulation. In patients with carotid steno-occlusive disease, studies have shown that MRI techniques can detect impaired CVR in brain tissue supplied by the affected artery. Moreover, resulting CVR estimations have been well correlated to those obtained with more established techniques, indicating that BOLD and ASL are robust and reliable methods to assess CVR in patients with cerebrovascular diseases. Therefore, the present paper aims to review recent studies which use BOLD and ASL to evaluate CVR, in healthy individuals and in patients with carotid steno-occlusive disease, providing a source of information regarding the obtained results and the methodological difficulties. 2017-05-29T14:11:12Z 2017-05-29T14:11:12Z 2012-04-17 article 2090-1941 https://repositorio.ufrn.br/jspui/handle/123456789/23173 eng Acesso Aberto application/pdf |
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RI - UFRN |
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eng |
| topic |
Carotid Steno-Occlusive Cerebrovascular Reactivity MRI BOLD ASL |
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Carotid Steno-Occlusive Cerebrovascular Reactivity MRI BOLD ASL Leoni, Renata F. Mazzetto-Betti, Kelley C. Silva, Afonso C. Santos, Antonio C. dos Araújo, Dráulio Barros de Leite, João P. Pontes-Neto, Octavio M. Assessing Cerebrovascular Reactivity in Carotid Steno-Occlusive Disease UsingMRI BOLD and ASL Techniques |
| description |
Impaired cerebrovascular reactivity (CVR), a predictive factor of imminent stroke, has been shown to be associated with carotid
steno-occlusive disease. Magnetic resonance imaging (MRI) techniques, such as blood oxygenation level-dependent (BOLD) and
arterial spin labeling (ASL), have emerged as promising noninvasive tools to evaluate altered CVR with whole-brain coverage,
when combined with a vasoactive stimulus, such as respiratory task or injection of acetazolamide. Under normal cerebrovascular
conditions, CVR has been shown to be globally and homogenously distributed between hemispheres, but with differences among
cerebral regions. Such differences can be explained by anatomical specificities and different biochemical mechanisms responsible
for vascular regulation. In patients with carotid steno-occlusive disease, studies have shown that MRI techniques can detect
impaired CVR in brain tissue supplied by the affected artery. Moreover, resulting CVR estimations have been well correlated
to those obtained with more established techniques, indicating that BOLD and ASL are robust and reliable methods to assess CVR
in patients with cerebrovascular diseases. Therefore, the present paper aims to review recent studies which use BOLD and ASL
to evaluate CVR, in healthy individuals and in patients with carotid steno-occlusive disease, providing a source of information
regarding the obtained results and the methodological difficulties. |
| format |
article |
| author |
Leoni, Renata F. Mazzetto-Betti, Kelley C. Silva, Afonso C. Santos, Antonio C. dos Araújo, Dráulio Barros de Leite, João P. Pontes-Neto, Octavio M. |
| author_facet |
Leoni, Renata F. Mazzetto-Betti, Kelley C. Silva, Afonso C. Santos, Antonio C. dos Araújo, Dráulio Barros de Leite, João P. Pontes-Neto, Octavio M. |
| author_sort |
Leoni, Renata F. |
| title |
Assessing Cerebrovascular Reactivity in Carotid Steno-Occlusive Disease UsingMRI BOLD and ASL Techniques |
| title_short |
Assessing Cerebrovascular Reactivity in Carotid Steno-Occlusive Disease UsingMRI BOLD and ASL Techniques |
| title_full |
Assessing Cerebrovascular Reactivity in Carotid Steno-Occlusive Disease UsingMRI BOLD and ASL Techniques |
| title_fullStr |
Assessing Cerebrovascular Reactivity in Carotid Steno-Occlusive Disease UsingMRI BOLD and ASL Techniques |
| title_full_unstemmed |
Assessing Cerebrovascular Reactivity in Carotid Steno-Occlusive Disease UsingMRI BOLD and ASL Techniques |
| title_sort |
assessing cerebrovascular reactivity in carotid steno-occlusive disease usingmri bold and asl techniques |
| publishDate |
2017 |
| url |
https://repositorio.ufrn.br/jspui/handle/123456789/23173 |
| work_keys_str_mv |
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| _version_ |
1773960345717571584 |