Assessing Cerebrovascular Reactivity in Carotid Steno-Occlusive Disease UsingMRI BOLD and ASL Techniques
Impaired cerebrovascular reactivity (CVR), a predictive factor of imminent stroke, has been shown to be associated with carotid steno-occlusive disease. Magnetic resonance imaging (MRI) techniques, such as blood oxygenation level-dependent (BOLD) and arterial spin labeling (ASL), have emerged as p...
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| Principais autores: | , , , , , , |
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| Formato: | article |
| Idioma: | eng |
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| Endereço do item: | https://repositorio.ufrn.br/jspui/handle/123456789/23173 |
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| Resumo: | Impaired cerebrovascular reactivity (CVR), a predictive factor of imminent stroke, has been shown to be associated with carotid
steno-occlusive disease. Magnetic resonance imaging (MRI) techniques, such as blood oxygenation level-dependent (BOLD) and
arterial spin labeling (ASL), have emerged as promising noninvasive tools to evaluate altered CVR with whole-brain coverage,
when combined with a vasoactive stimulus, such as respiratory task or injection of acetazolamide. Under normal cerebrovascular
conditions, CVR has been shown to be globally and homogenously distributed between hemispheres, but with differences among
cerebral regions. Such differences can be explained by anatomical specificities and different biochemical mechanisms responsible
for vascular regulation. In patients with carotid steno-occlusive disease, studies have shown that MRI techniques can detect
impaired CVR in brain tissue supplied by the affected artery. Moreover, resulting CVR estimations have been well correlated
to those obtained with more established techniques, indicating that BOLD and ASL are robust and reliable methods to assess CVR
in patients with cerebrovascular diseases. Therefore, the present paper aims to review recent studies which use BOLD and ASL
to evaluate CVR, in healthy individuals and in patients with carotid steno-occlusive disease, providing a source of information
regarding the obtained results and the methodological difficulties. |
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